DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment conu and rga3

DIOPT Version :9

Sequence 1:	NP_001036454.1	Gene:	conu / 3355133	FlyBaseID:	FBgn0039994	Length:	629	Species:	Drosophila melanogaster
Sequence 2:	NP_594871.1	Gene:	rga3 / 2542306	PomBaseID:	SPAC29A4.11	Length:	969	Species:	Schizosaccharomyces pombe

Alignment Length:	590	Identity:	117/590 - (19%)
Similarity:	205/590 - (34%)	Gaps:	173/590 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EYYLQSNSQSIEPEASYEDGEMEAEWLVSAGYPELTKPFEQGLEVSKKDLEPILTTLSKPHAEAI 85
            ||:|.:|..|..|..|..|.::|          ||.:..|.            ||.|:|..:|.:
pombe   435 EYHLPTNDHSSTPAQSERDSDVE----------ELREQLEN------------LTALTKKLSERL 477

  Fly    86 -------VQLVRTLNK-TVRVR--------------TKSRPKRKPDIRDVFREFDEQGTVTRSRS 128
                   .:.:||.:| |||..              |.....:.|..:|:....:....:.|...
pombe   478 SSSTFDNSKFIRTEDKDTVRSAKLEICEKFFSFADVTDDPTLKDPKHQDLVAAANAYMAMLRESY 542

  Fly   129 ATP---------DSLDSLQIDEAWTNNSLPTFVNVYEKNTETAIQCVEQSNEIYLKQ-------- 176
            .|.         :.||.....:...|.||...|::..||.|.|     ..|...:||
pombe   543 GTEINNLLERRNELLDDYNNVQKILNESLEASVHLNTKNLELA-----DLNNNLVKQIQHRVPPE 602

  Fly   177 ---NLRRTPSAPPKSGTYADIFRGSQVRCDIPLYSADG------------------VELLGYSRI 220
               ||..|.:...|:.|       |.:.....:.|..|                  :::.|  :.
pombe   603 NQSNLEHTITTSSKNTT-------SSINPLTAVSSNSGQSSGRPGPLSPNLNVTTRIDIKG--KK 658

  Fly   221 GTIQF-PR--NRSVSDPFCSIGRSKESRSE---NDARSQKK---------KSSEVLSASENECGR 270
            |::.. ||  ||.|  ||.|:....:|...   |:.|:|..         |.|.....||:..|.
pombe   659 GSMHLQPRDVNRKV--PFKSMHTKSKSADPVVGNEDRTQCDHVFHVNAIFKPSRCYICSESVWGS 721

  Fly   271 LLPMPYNVLSFESICRDSSSLDSCEVLDTCDIPSTLFTDVVLISETDMKRLQTI----LWL-ELA 330
            .|...:..:|..|.|.                 ..||.:    ||.:....:|:    .|: |:.
pombe   722 ELRCFHCSISCHSRCL-----------------KRLFAE----SEHEKTMSETVSENSKWMPEMP 765

  Fly   331 TIFDRNKVSLDKRKPFKRRRKEEG---NLFGVSINALIRRDQQVTGTDSSLVPLFLEKLIGELLR 392
            |                 |....|   .:||.|:...::       .:.|::|..:...:..:..
pombe   766 T-----------------RMPPPGPSPTMFGRSLENQLK-------IEGSVLPQVIAMCVSCVDA 806

  Fly   393 RGSREEGLLRIGGHKQKTELLYNELESTFYQNPDNLDNLFRTATVHELSSLLKRWLRELPQPLLT 457
            .|...||:.||.|...:..:|.:|.|:    ....:::|  |:.:...:|:||.:|..||:|::.
pombe   807 HGLEVEGIYRISGSASQVRVLVDEFEN----GSIRMEHL--TSDLFACTSVLKTYLHRLPEPVIP 865

  Fly   458 NELIQLFYQCHTLPSIDQ-MNALSILCHLLPPENRNTLRSLLSFFNIIINLKDINKMNVHNVATI 521
            ....:...:...:...:: :..:..:...|.|.:.:..|.|::....:....:.|.||..||:|:
pombe   866 GTQYEELLEAEKIEKEEEKIERVVEVMKTLHPAHLSVFRFLIAHLGRVCKHAEKNLMNSKNVSTV 930

  Fly   522 MAPSM 526
            .||::
pombe   931 FAPTL 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
conu	NP_001036454.1	RhoGAP_ARHGAP18	356..576	CDD:239856	35/172 (20%)
rga3	NP_594871.1	LIM	18..74	CDD:214528
		LIM	78..128	CDD:259829
		C1	698..743	CDD:237996	11/61 (18%)
		RhoGAP	791..962	CDD:214618	32/151 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910