Protein Alignment lt and VPS41

DIOPT Version :10

• Sequence 1: NP_001036415.2
• Gene: lt / 3355130
• FlyBaseID: FBgn0002566
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_010365.3
• Gene: VPS41 / 851653
• SGDID: S000002487
• Length: 992
• Species: Saccharomyces cerevisiae
• Alignment Length: 923
• Identity: 202/923 - (21%)
• Similarity: 373/923 - (40%)
• Gaps: 211/923 - (22%)

  Fly    18 NEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYSNLSASER 82
            ::||..|..||.|::...|.....|.|:.......|..|||..|.:    |.....:..:...:.
Yeast    93 DDEDEPPLLKYTRISQLPKNFFQRDSISSCLFGDTFFAFGTHSGIL----HLTTCAFEPIKTIKC 153

  Fly    83 HTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPDSKAHIKRFV 147
            |...:...|.|    |:|.||.|.||.|.|..:....|.....|.:.|..|:|..:.:|. :.||
Yeast   154 HRSSILCINTD----GKYFATGSIDGTVIIGSMDDPQNITQYDFKRPINSVALHSNFQAS-RMFV 213

  Fly   148 VGD--DKLILYERNLL-------------KKLKPVELCS-VEGSVLSICWHGNFIAWASHIGVRV 196
            .|.  ..::|.:||.|             ||.:..:|.| ::|.::.|...|:.|.|....|:..
Yeast   214 SGGMAGDVVLSQRNWLGNRIDIVLNKKKKKKTRKDDLSSDMKGPIMGIYTMGDLILWMDDDGITF 278

  Fly   197 YDLNERCSLGLIKWEVPPQERLEN--------FRCHLRWSNKHTLLIGWVDTI---RVCVIRKRN 250
            .|:..|..|    ..:|...|:.|        ||.|:.:.....::|||...|   :|...:..|
Yeast   279 CDVPTRSQL----LNIPFPSRIFNVQDVRPDLFRPHVHFLESDRVVIGWGSNIWLFKVSFTKDSN 339

  Fly   251 SIEAS--------------TGNLPVYIVDPISTFQTT--------------FYVCGLAPLSAKQL 287
            ||::.              |.|:...:....|:|:.|              ..:.|||.....||
Yeast   340 SIKSGDSNSQSNNMSHFNPTTNIGSLLSSAASSFRGTPDKKVELECHFTVSMLITGLASFKDDQL 404

  Fly   288 VVLGF---------------------RKEKSSCFKALRPVLCVIEYKMNNSEEICTDSLTLRGFE 331
            :.|||                     ::.::...|...|.|.:::  :.|.:||..|.:.::.:|
Yeast   405 LCLGFDIDIEEEATIDEDMKEGKNFSKRPENLLAKGNAPELKIVD--LFNGDEIYNDEVIMKNYE 467

  Fly   332 EYTVNDYSLGGIIEEN--RFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAMELISANGGNVPV 394
            :.::|||.||..|::.  .:|:::..|.:....:...|..:|.::..::.:|.::.....|:...
Yeast   468 KLSINDYHLGKHIDKTTPEYYLISSNDAIRVQELSLKDHFDWFMERKQYYKAWKIGKYVIGSEER 532

  Fly   395 LSVAKLYINHLLALKKYD---DAAKLCLRMLGN----------DKVL--WEEEVFKFVKCQQLRS 444
            .|:...::|.|:..|.:.   |...:......|          ..||  |.:.:...:....:..
Yeast   533 FSIGLKFLNSLVTKKDWGTLVDHLNIIFEETLNSLDSNSYDVTQNVLKEWADIIEILITSGNIVE 597

  Fly   445 VSAYLPTSDECKLDPHVYEMVLYEFLKFDVCG-FLNLIKEWPSHLYDGLAVINAIHDNFRKH--- 505
            ::..:|...  .|...||:.||:.||..|:.. |...|.:|...|:       ::.| |.:.
Yeast   598 IAPLIPKKP--ALRKSVYDDVLHYFLANDMINKFHEYITKWDLKLF-------SVED-FEEELET 652

  Fly   506 --------------------YANQLLESLALLYSYQGDFESALRMYLKLQNKDVFQLIR------ 544
                                |..:|:.    ||..:..:..|:...||.::.....:|:
Yeast   653 RIEAASEPTASSKEEGSNITYRTELVH----LYLKENKYTKAIPHLLKAKDLRALTIIKIQNLLP 713

  Fly   545 RY--ELYDV-----------ISKLIIPLIQLDRDCAFEILLDKKKIKTEIVVHQL-EHN-----Q 590
            :|  ::.|:           ||||.|..||...:...::|.:.:...:...:::: ||:     :
Yeast   714 QYLDQIVDIILLPYKGEISHISKLSIFEIQTIFNKPIDLLFENRHTISVARIYEIFEHDCPKSFK 778

  Fly   591 EYLYWYLDSLLKKDPS---NVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALVICKQE-NFYP 651
            :.|:.||...|..|.|   :.::.:||.||:.:||..|||||::..:|:::.|:.:|..: ..|.
Yeast   779 KILFCYLIKFLDTDDSFMISPYENQLIELYSEYDRQSLLPFLQKHNNYNVESAIEVCSSKLGLYN 843

  Fly   652 EIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALIN------EFSK------ 704
            |::||.|.:|  |..:||::||..:::.::||:|.|...||:||..:||      .|:|
Yeast   844 ELIYLWGKIG--ETKKALSLIIDELKNPQLAIDFVKNWGDSELWEFMINYSLDKPNFTKAILTCS 906

  Fly   705 --HPEIVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGE-------ILSSAQ 760
              ..||..||:.|:.|             ...|.||:..:..:::..:|..|       |::...
Yeast   907 DETSEIYLKVIRGMSD-------------DLQIDNLQDIIKHIVQENSLSLEVRDNILVIINDET 958

  Fly   761 QIQLNDYFEIHSE 773
            :...|::.:|.|:
Yeast   959 KKFANEFLKIRSQ 971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	9/47 (19%)
		WD40 repeat	90..123	CDD:293791	12/32 (38%)
		WD40 repeat	130..168	CDD:293791	13/52 (25%)
		CLH	570..707	CDD:128594	46/160 (29%)
VPS41	NP_010365.3	WD40	145..179	CDD:197651	11/37 (30%)
		WD40	<146..>223	CDD:441893	21/81 (26%)
		CLH	753..896	CDD:128594	44/144 (31%)