Protein Alignment lt and Vps41

DIOPT Version :10

• Sequence 1: NP_001036415.2
• Gene: lt / 3355130
• FlyBaseID: FBgn0002566
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_001386247.1
• Gene: Vps41 / 306991
• RGDID: 1560511
• Length: 853
• Species: Rattus norvegicus
• Alignment Length: 845
• Identity: 318/845 - (37%)
• Similarity: 491/845 - (58%)
• Gaps: 42/845 - (4%)

  Fly    11 DSWADSINEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYS 75
            :|..:|..|.:.|||.||.||:|.:..:|..|..:|..||.|||..||..|:|.:.|.||| :..
  Rat    14 ESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGN-ITQ 77

  Fly    76 NLSASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPD-S 139
            ....|     .|.:|.|.:|..||::..||:|||:.:.||:|.:..|. :|...||:|::.|. .
  Rat    78 KFDVS-----PVKINQISLDESGEHMGVCSEDGKLQVFGLYSGEEFHE-TFDCPIKIVAVHPQFV 136

  Fly   140 KAHIKRFVVGDDKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDLNERCS 204
            ::..|:||.|..||:|:||..:.:.|...|...||::.|:.|.|:.||||:::||:::|:..:..
  Rat   137 RSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDITSKQR 201

  Fly   205 LGLIKWEVPPQE---RLENFRCHLRWSNKHTLLIGWVDTIRVCVIRKRNSIEASTGNLPVYIVDP 266
            :    ..||..:   |.:.:.|.|.|.:..||:|||..:|::|.:::|::.|..  :||...|:.
  Rat   202 I----TNVPRDDISLRPDMYPCSLCWKDAVTLIIGWGTSIKICSVKERHASEMR--DLPSRYVEI 260

  Fly   267 ISTFQTTFYVCGLAPLSAKQLVVLGFRKEKSS------CFKALRPVLCVIEYKMNNSEEICTDSL 325
            :|.|:|.||:.||||| ..|||||.:.||.|.      |   .||.|.:|:......|||.:|:|
  Rat   261 VSQFETEFYISGLAPL-CDQLVVLSYVKEVSEKTEREYC---ARPRLDIIQPLPETCEEISSDAL 321

  Fly   326 TLRGFEEYTVNDYSLGGIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAMELISANGG 390
            |:|||:|....||.|.....|:.||:|:|:|:|||...:.||.|:||::..|:|||:.....:..
  Rat   322 TVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISHR 386

  Fly   391 NV---PVLSVAKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAYLPTS 452
            |:   .:|.:...|:|||:...:||.||:.|.::||.:..|||.||:||.:..||:::|.|||..
  Rat   387 NIKRHKILEIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRG 451

  Fly   453 DECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQ-LLESLAL 516
            |.. |.|.:|||:|:|||:.|..||..||:|||..||:...::.|:.|:.:|...|: ||::||.
  Rat   452 DPV-LKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAE 515

  Fly   517 LYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDKK-KIKTE 580
            ||:|..::.:||.:||.|::|||||||.::.|:..|...|:.|:..|.:.|.::|||.: ||..:
  Rat   516 LYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIK 580

  Fly   581 IVVHQLEHNQEYLYWYLDSLLKKD--PSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALVI 643
            .||.:||...|..:.||..|.|:|  ....:.:|.|||||.:||..|||||:.|....:::||.|
  Rat   581 KVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEI 645

  Fly   644 CKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPEI 708
            |:|.||..|.||||..||  .:..||.:|:..:.|::.||||.||.||.:||..||......|..
  Rat   646 CQQRNFVEETVYLLSRMG--NSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPF 708

  Fly   709 VTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEIHSE 773
            :|.:|:.|..:..|.:::.:||.|..|||||.||:|:|:.||||..:....::|.:.|...:..:
  Rat   709 ITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKK 773

  Fly   774 IVTTQRRGQQVSYEQLCSLCHRPVLMA-GTHLYCIIRLECGHVYHKPCIQGELL----KNCNECN 833
            :..||.:|..|..|.:|..|..|:|.. ....:.::...|.|::||.|:....|    :.||.|:
  Rat   774 MHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSLNAPAQYCNICS 838

  Fly   834  833
              Rat   839  838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	17/47 (36%)
		WD40 repeat	90..123	CDD:293791	13/32 (41%)
		WD40 repeat	130..168	CDD:293791	14/38 (37%)
		CLH	570..707	CDD:128594	59/139 (42%)
Vps41	NP_001386247.1	WD40 repeat	136..168	CDD:293791	11/31 (35%)
		WD40 repeat	173..204	CDD:293791	10/34 (29%)
		CLH	570..707	CDD:128594	59/138 (43%)
		RING-H2_Vps41	786..840	CDD:438351	14/53 (26%)