Protein Alignment lt and VPS41

DIOPT Version :10

• Sequence 1: NP_001036415.2
• Gene: lt / 3355130
• FlyBaseID: FBgn0002566
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_055211.2
• Gene: VPS41 / 27072
• HGNCID: 12713
• Length: 854
• Species: Homo sapiens
• Alignment Length: 848
• Identity: 321/848 - (37%)
• Similarity: 492/848 - (58%)
• Gaps: 42/848 - (4%)

  Fly     9 SCDSWADSINEE--DVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGN 71
            |.:...|...||  :.|||.||.||:|.:..:|..|..:|..||.|||..||..|:|.:.|.|||
Human    11 SLEESTDESEEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGN 75

  Fly    72 SVYSNLSASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLE 136
             :......|     .|.:|.|.:|..||::..||:||||.:.||:|.:..|. :|...||::::.
Human    76 -ITQKFDVS-----PVKINQISLDESGEHMGVCSEDGKVQVFGLYSGEEFHE-TFDCPIKIIAVH 133

  Fly   137 PD-SKAHIKRFVVGDDKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDL- 199
            |. .::..|:||.|..||:|:||:.:.:.|...|...||::.|:.|.|:.||||:::||:::|:
Human   134 PHFVRSSCKQFVTGGKKLLLFERSWMNRWKSAVLHEGEGNIRSVKWRGHLIAWANNMGVKIFDII 198

  Fly   200 -NERCSLGLIKWEVPPQE---RLENFRCHLRWSNKHTLLIGWVDTIRVCVIRKRNSIEASTGNLP 260
             .:|.:      .||..:   |.:.:.|.|.|.:..||:|||..:::||.:::|::.|..  :||
Human   199 SKQRIT------NVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSVKVCSVKERHASEMR--DLP 255

  Fly   261 VYIVDPISTFQTTFYVCGLAPLSAKQLVVLGFRK---EKSSCFKALRPVLCVIEYKMNNSEEICT 322
            ...|:.:|.|:|.||:.||||| ..|||||.:.|   ||:......||.|.:|:......|||.:
Human   256 SRYVEIVSQFETEFYISGLAPL-CDQLVVLSYVKEISEKTEREYCARPRLDIIQPLSETCEEISS 319

  Fly   323 DSLTLRGFEEYTVNDYSLGGIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAM---EL 384
            |:||:|||:|....||.|.....|:.||||:|:|:|||...:.||.|:||::..|:|||:   |:
Human   320 DALTVRGFQENECRDYHLEYSEGESLFYIVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEI 384

  Fly   385 ISANGGNVPVLSVAKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAYL 449
            ...|.....:|.:...|||||:....||.||:.|.::||.:..|||.||:||.:..||:::|.||
Human   385 SQKNIKRHKILDIGLAYINHLVERGDYDIAARKCQKILGKNAALWEYEVYKFKEIGQLKAISPYL 449

  Fly   450 PTSDECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQ-LLES 513
            |..|.. |.|.:|||:|:|||:.|..||..||:|||..||:...::.|:.|:.:|...|: ||::
Human   450 PRGDPV-LKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKT 513

  Fly   514 LALLYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDKK-KI 577
            ||.||:|..::.:||.:||.|::|||||||.::.|:..|...|:.|:..|.:.|.::|||.: ||
Human   514 LAELYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKI 578

  Fly   578 KTEIVVHQLEHNQEYLYWYLDSLLKKD--PSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEA 640
            ..:.||.:||...|..:.||..|.|:|  ....:.:|.|||||.:||..|||||:.|....:::|
Human   579 SIKKVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKA 643

  Fly   641 LVICKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKH 705
            |.||:|.||..|.||||..||  .:..||.:|:..:.|::.||||.||.||.:||..||......
Human   644 LEICQQRNFVEETVYLLSRMG--NSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDK 706

  Fly   706 PEIVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEI 770
            |..:|.:|:.|..:..|.:::.:||.|..|||||.||:|:|:.||||..:....::|.:.|...:
Human   707 PPFITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSL 771

  Fly   771 HSEIVTTQRRGQQVSYEQLCSLCHRPVLMA-GTHLYCIIRLECGHVYHKPCI----QGELLKNCN 830
            ..::..||.:|..|..|.:|..|..|:|.: ....:.::...|.|::||.|:    .....:.||
Human   772 LKKMHRTQMKGVLVDEENICESCLSPILPSDAAKPFSVVVFHCRHMFHKECLPMPSMNSAAQFCN 836

  Fly   831 ECN 833
            .|:
Human   837 ICS 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	17/47 (36%)
		WD40 repeat	90..123	CDD:293791	14/32 (44%)
		WD40 repeat	130..168	CDD:293791	13/38 (34%)
		CLH	570..707	CDD:128594	59/139 (42%)
VPS41	NP_055211.2	Interaction with ARL8B. /evidence=ECO:0000269|PubMed:25908847	1..540		211/545 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		8/21 (38%)
		WD40 repeat	138..169	CDD:293791	11/30 (37%)
		WD40 repeat	174..205	CDD:293791	11/36 (31%)
		CHCR	568..712		60/145 (41%)
		CLH	571..708	CDD:128594	59/138 (43%)
		RING-H2_Vps41	787..841	CDD:438351	13/53 (25%)