Protein Alignment lt and vps41

DIOPT Version :10

• Sequence 1: NP_001036415.2
• Gene: lt / 3355130
• FlyBaseID: FBgn0002566
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_593409.2
• Gene: vps41 / 2542058
• PomBaseID: SPAP27G11.05C
• Length: 871
• Species: Schizosaccharomyces pombe
• Alignment Length: 801
• Identity: 221/801 - (27%)
• Similarity: 377/801 - (47%)
• Gaps: 83/801 - (10%)

  Fly    11 DSWADSI--NEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSV 73
            ||..|||  ::||.|||..|.|:....:.....|.|:..|:..:...||:..|.:.|:...|
pombe     9 DSEIDSISSSDEDEEPKLIYERITEKFQGCFMNDTISACAISKEHFFFGSHNGAIYIYQKNG--- 70

  Fly    74 YSNLSASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNN-HSLSFGKFIKVVSLEP 137
               :...:...|..:|.::.||.:.|.:|:||.|||:.|:.:.:.:.. |  .|.:.:..|:::|
pombe    71 ---ILLRKMILHSASVVDLSVDLESENLASCSMDGKMIISNITTRETTVH--DFKRPLLSVAIDP 130

  Fly   138 DSKAHIKRFVVGD---DKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDL 199
            .......|.|:..   .|::|.|:..|.. |...|.:..|:|..|.|:..:|||||.:|:.||.
pombe   131 YYSTRSSRQVLSGGRAGKVVLSEKGWLGN-KDTVLQADCGAVYKISWYTTYIAWASDLGITVYS- 193

  Fly   200 NERCSLGLIKWEVPPQERLEN---FRCHLRWSNKHTLLIGWVDTIRVCVIRKRN--------SIE 253
               ...|.:...:.|.:||.|   |...|.|.::..|:|||.|.|.:..|::.|        |::
pombe   194 ---TEFGKVLGRLEPPKRLPNDEIFPYQLFWQSESRLVIGWSDQIMIVSIQRSNVANELPKISLQ 255

  Fly   254 ASTGNLPVYIVDPISTFQTTFYVCGLAPLSAKQLVVLGFR----------KEKSSCFKALRPVLC 308
            |      :..:|.|        |.|        :::|||.          ::.:|...:.|...|
pombe   256 A------LLEIDSI--------VSG--------VLMLGFNILTLAYIANVEDFTSAIPSQRIEGC 298

  Fly   309 VIEYKMNNS--EEICTDSLTLRGFEEYTVNDYSLGGIIEEN-RFYIVAPKDIVVASLIETDDRIE 370
            ..|.::.:|  :|:|.|::.|..:.....:||.|......| ..::::|.|||........|.::
pombe   299 RPELRLIDSSFKELCGDAIGLANYSRLQPSDYHLLPDPSSNSHSFVISPNDIVYVRERNQIDHVK 363

  Fly   371 WLIKHSKFEEAMELISANGGNVPVLSV---AKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEE 432
            :|:....:.||::.:.......|.|.:   ||.||.|||...:|.:|..:...:..::...||:.
pombe   364 YLVSKEMYAEAIDAVKKLPEIPPSLQISELAKKYIFHLLGKGQYKEAGMVIPSLYNDNLAEWEQW 428

  Fly   433 VFKFVKCQQLRSVSAYLPTSDECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINA 497
            ||.|.:...|..::.:|||. |..|.|.||||:|.::|..|...|...:.|||:.||....:.||
pombe   429 VFVFAENDHLEDIADFLPTG-ENHLSPLVYEMILAQYLATDERTFNKKLHEWPTMLYSVSTIRNA 492

  Fly   498 IHDNFRKHY-ANQLLESLALLYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDV--ISKLIIPL 559
            ....|:::. ::.|.||||.||........|..:||||.::....||.::.|||.  .|.|::.|
pombe   493 TLKKFKENQKSSTLTESLAFLYLEDNMPIDAFHLYLKLHSELCIDLILQHNLYDEARASVLLLML 557

  Fly   560 I-----QLDRDCAFEILLDK--KKIKTEIVVHQLEHNQEYLYWYLDSLLKKDPSNVFQ--KKLIS 615
            |     ..|...|...:|.:  .....:.|:.|:....::||.|........|:::.:  ...:.
pombe   558 ISSKGKSSDTKSAMSSMLVQHVHSFPPQEVIMQIHSVPQFLYEYFCEFELMYPNSLMEYGDLKLD 622

  Fly   616 LYAIFDRNKLLPFLKRSKDYDIQEALVICKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIE 680
            ::|.|||.:...||..::.|.:..|..||||.|:..|:||:||.||  ...|||.:||:.:.||.
pombe   623 VFAEFDRKRFFDFLVNTQCYSLDHAAQICKQYNYLDELVYILGRMG--NNKEALMLIINELLDIG 685

  Fly   681 MAIEFCKEHDDSDLWNALINEFSKHPEIVTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKM 745
            .||.:.||..|.:||:.||:.....||.:..:|:.|....:...::.||..|..:|::::|:.|:
pombe   686 RAIRYVKEQADRELWDDLISYSLDKPEFICTLLENIGTDENARNLLSKIPPGTKLPHMKKSISKL 750

  Fly   746 LRHYNLQGEILSSAQQIQLND 766
            |..:..|.::..|..::..|:
pombe   751 LADHQSQVQLYQSCYKLFKNE 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	8/47 (17%)
		WD40 repeat	90..123	CDD:293791	10/33 (30%)
		WD40 repeat	130..168	CDD:293791	9/40 (23%)
		CLH	570..707	CDD:128594	43/140 (31%)
vps41	NP_593409.2	WD40	44..>204	CDD:475233	44/172 (26%)
		WD40 repeat	44..78	CDD:293791	7/39 (18%)
		WD40 repeat	84..118	CDD:293791	11/35 (31%)
		WD40 repeat	123..167	CDD:293791	10/44 (23%)
		WD40 repeat	172..204	CDD:293791	11/35 (31%)
		CLH	<625..712	CDD:128594	36/88 (41%)