Protein Alignment lt and Vps41

DIOPT Version :10

• Sequence 1: NP_001036415.2
• Gene: lt / 3355130
• FlyBaseID: FBgn0002566
• Length: 841
• Species: Drosophila melanogaster
• Sequence 2: NP_742118.3
• Gene: Vps41 / 218035
• MGIID: 1929215
• Length: 853
• Species: Mus musculus
• Alignment Length: 845
• Identity: 318/845 - (37%)
• Similarity: 490/845 - (57%)
• Gaps: 42/845 - (4%)

  Fly    11 DSWADSINEEDVEPKFKYHRLANDLKYMLNADVITCSAVHLKFLIFGTFRGRVCIFDHQGNSVYS 75
            :|..:|..|.:.|||.||.||:|.:..:|..|..:|..||.|||..||..|:|.:.|.||| :..
Mouse    14 ESTDESEEESEEEPKLKYERLSNGVTEILQKDAASCMTVHDKFLALGTHYGKVYLLDVQGN-ITQ 77

  Fly    76 NLSASERHTHQVAVNNIDVDHKGEYVATCSDDGKVNITGLFSSDNNHSLSFGKFIKVVSLEPD-S 139
            ....|     .|.:|.|.:|..||::..||:|||:.:.||:|.:..|. :|...||::::.|. .
Mouse    78 KFDVS-----PVKINQISLDDSGEHMGVCSEDGKLQVFGLYSGEEFHE-TFDCPIKIIAVHPQFV 136

  Fly   140 KAHIKRFVVGDDKLILYERNLLKKLKPVELCSVEGSVLSICWHGNFIAWASHIGVRVYDLNERCS 204
            ::..|:||.|..||:|:||..:.:.|...|...||::.|:.|.|:.||||:::||:|:|:..:..
Mouse   137 RSSCKQFVTGGKKLLLFERTWMNRWKSSVLHEGEGNIRSVKWRGHLIAWANNMGVKVFDITSKQR 201

  Fly   205 LGLIKWEVPPQE---RLENFRCHLRWSNKHTLLIGWVDTIRVCVIRKRNSIEASTGNLPVYIVDP 266
            :.    .||..:   |.:.:.|.|.|.:..||:|||..:|::|.:::|::.|..  :||...|:.
Mouse   202 IS----NVPRDDISLRPDMYPCSLCWKDNVTLIIGWGTSIKICSVKERHASEMR--DLPSRYVEI 260

  Fly   267 ISTFQTTFYVCGLAPLSAKQLVVLGFRKEKSS------CFKALRPVLCVIEYKMNNSEEICTDSL 325
            :|.|:|.||:.||||| ..|||||.:.||.|.      |   .||.|.:|:......|||.:|:|
Mouse   261 VSQFETEFYISGLAPL-CDQLVVLSYVKEVSEKTEREYC---ARPRLDIIQPLPETCEEISSDAL 321

  Fly   326 TLRGFEEYTVNDYSLGGIIEENRFYIVAPKDIVVASLIETDDRIEWLIKHSKFEEAM---ELISA 387
            |:|||:|....||.|.....|:.||:|:|:|:|||...:.||.|:||::..|:|||:   |:...
Mouse   322 TVRGFQENECRDYHLEYSEGESLFYVVSPRDVVVAKERDQDDHIDWLLEKKKYEEALMAAEISQR 386

  Fly   388 NGGNVPVLSVAKLYINHLLALKKYDDAAKLCLRMLGNDKVLWEEEVFKFVKCQQLRSVSAYLPTS 452
            |.....:|.:...|:|||:...:||.||:.|.::||.:..|||.||:||.:..||:::|.|||..
Mouse   387 NIKRHKILDIGLAYVNHLVERGEYDMAARKCQKILGKNASLWEYEVYKFKEIGQLKAISPYLPRG 451

  Fly   453 DECKLDPHVYEMVLYEFLKFDVCGFLNLIKEWPSHLYDGLAVINAIHDNFRKHYANQ-LLESLAL 516
            |.. |.|.:|||:|:|||:.|..||..||:|||..||:...::.|:.|:.:|...|: ||::||.
Mouse   452 DPV-LKPLIYEMILHEFLESDYEGFATLIREWPGDLYNNSVIVQAVRDHLKKDSQNKTLLKTLAE 515

  Fly   517 LYSYQGDFESALRMYLKLQNKDVFQLIRRYELYDVISKLIIPLIQLDRDCAFEILLDKK-KIKTE 580
            ||:|..::.:||.:||.|::|||||||.::.|:..|...|:.|:..|.:.|.::|||.: ||..:
Mouse   516 LYTYDKNYGNALEIYLTLRHKDVFQLIHKHNLFSSIKDKIVLLMDFDSEKAVDMLLDNEDKISIK 580

  Fly   581 IVVHQLEHNQEYLYWYLDSLLKKD--PSNVFQKKLISLYAIFDRNKLLPFLKRSKDYDIQEALVI 643
            .||.:||...|..:.||..|.|:|  ....:.:|.|||||.:||..|||||:.|....:::||.|
Mouse   581 KVVEELEDRPELQHVYLHKLFKRDHHKGQRYHEKQISLYAEYDRPNLLPFLRDSTHCPLEKALEI 645

  Fly   644 CKQENFYPEIVYLLGCMGGVEASEALNIIIHRIRDIEMAIEFCKEHDDSDLWNALINEFSKHPEI 708
            |:|.||..|.||||..||  .:..||.:|:..:.|::.||||.||.||.:||..||......|..
Mouse   646 CQQRNFVEETVYLLSRMG--NSRSALKMIMEELHDVDKAIEFAKEQDDGELWEDLILYSIDKPPF 708

  Fly   709 VTKVLDGIVDYFSPAVVVGKIKMGQNIPNLRQSLIKMLRHYNLQGEILSSAQQIQLNDYFEIHSE 773
            :|.:|:.|..:..|.:::.:||.|..|||||.||:|:|:.||||..:....::|.:.|...:..:
Mouse   709 ITGLLNNIGTHVDPILLIHRIKEGMEIPNLRDSLVKILQDYNLQILLREGCKKILVADSLSLLKK 773

  Fly   774 IVTTQRRGQQVSYEQLCSLCHRPVLMA-GTHLYCIIRLECGHVYHKPCI----QGELLKNCNECN 833
            :..||.:|..|..|.:|..|..|:|.. ....:.::...|.|::||.|:    .....:.||.|:
Mouse   774 MHRTQMKGVLVDEENICESCLSPILPTDAAKPFSVVVFHCRHMFHKECLPMPSMNAPAQYCNICS 838

  Fly   834  833
            Mouse   839  838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lt	NP_001036415.2	WD40 repeat	33..81	CDD:293791	17/47 (36%)
		WD40 repeat	90..123	CDD:293791	13/32 (41%)
		WD40 repeat	130..168	CDD:293791	13/38 (34%)
		CLH	570..707	CDD:128594	59/139 (42%)
Vps41	NP_742118.3	Interaction with ARL8B. /evidence=ECO:0000250|UniProtKB:P49754	1..539		208/542 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..32		7/17 (41%)
		WD40 repeat	87..131	CDD:293791	17/44 (39%)
		WD40 repeat	174..206	CDD:293791	11/35 (31%)
		CHCR	567..711		60/145 (41%)
		CLH	570..707	CDD:128594	59/138 (43%)
		RING-H2_Vps41	786..840	CDD:438351	13/53 (25%)