Protein Alignment IntS3 and INTS3

DIOPT Version :10

• Sequence 1: NP_001036437.1
• Gene: IntS3 / 3355010
• FlyBaseID: FBgn0262117
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_075391.3
• Gene: INTS3 / 65123
• HGNCID: 26153
• Length: 1042
• Species: Homo sapiens
• Alignment Length: 1095
• Identity: 424/1095 - (38%)
• Similarity: 639/1095 - (58%)
• Gaps: 127/1095 - (11%)

  Fly    14 KLFICTAVDCKDDIEEKFERSFVTLQMQISGLSDKEMHDMLSQAVCKE-KQHEEISIGFLYIMLT 77
            :|.:.|::|.||::||:.||....:....:|:|::|.:|.|:..|||. .|||||.:|...::||
Human    35 RLLLSTSLDAKDELEERLERCMSIVTSMTAGVSEREANDALNAYVCKGLPQHEEICLGLFTLILT 99

  Fly    78 DPSMASKTYRDVTLVSRDGMNGIVTNLTFLVAEKYTKLTEVARRQLIWLLREFVKHQVLSVENVI 142
            :|:.|.|.|||:.||||||||.::..:..::.|||.||.:..|.||:||:||.||..||..:.|.
Human   100 EPAQAQKCYRDLALVSRDGMNIVLNKINQILMEKYLKLQDTCRTQLVWLVRELVKSGVLGADGVC 164

  Fly   143 WNCLRQAGGGDVSSRNLFLIESLLDIFIEFRTWLETNPFLVQSTVYSFVRLIEDHANPA-LLSLR 206
            ...::|..||||:::|::|.||:|||..|.|.|:..:..|:...||:::|||.||...| |.:||
Human   165 MTFMKQIAGGDVTAKNIWLAESVLDILTEQREWVLKSSILIAMAVYTYLRLIVDHHGTAQLQALR 229

  Fly   207 QKEVKFTISLIRERFHDIIPLGRDFVRLLQNVARIPEFEQLWRDILFNPKMLHQTFNGIWQLLHI 271
            ||||.|.|||:||||.:.:.:|||.||||||||||||||.||:||:.||:.|...|.||.|||..
Human   230 QKEVDFCISLLRERFMECLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQS 294

  Fly   272 RTSRRFLQCRLLPEMERKISFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIINVIHP 336
            ||||:||.|||.|:||.|:.|:.|.|:||.|||||||||.:|.:||:|.|||.||||:|..|:||
Human   295 RTSRKFLACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHP 359

  Fly   337 TNDMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNIEPGILVMYHSIR 401
            :|::|.|||:|||||||||:::||:.:|::||||:||||||||.|.||:||||||.||||:||::
Human   360 SNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMK 424

  Fly   402 NHPFVSSTLLDFLCRITKNFFVKHEDKIRIGVYNSLKLILEKQVIPNLQPLFESPKLDRELRNLI 466
            .||.:::|||||:|||..||:...|..:|.||::||..|:||:|:.:|.|||::||||:|||.::
Human   425 PHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRAML 489

  Fly   467 RDNFREFLSPPANHGQLLFTSLHPVQGHILKKESDQRILHCENMDLHETGLINISGTIDEDKKIL 531
            |:.|.||.|.|:          .||:..|.:..|.:       ||.|.:         |:|:...
Human   490 REKFPEFCSSPS----------PPVEVKIEEPVSME-------MDNHMS---------DKDESCY 528

  Fly   532 LVPTDQEIESVFSDETAENLR--------RVHNIEDNTDD------------DDDLPLSEVRLKE 576
                 ...|:.|||: .|:|.        |.|.|::...:            |:.|....::|::
Human   529 -----DNAEAAFSDD-EEDLNSKGKKREFRFHPIKETVVEEPVDITPYLDQLDESLRDKVLQLQK 587

  Fly   577 KPKVEL-AEAIAESFDAFVTKRNSYTWEAFLKDFRPLPASAFEE-FQLNYVISNTVLILRETLPQ 639
            ....|. .|.:.|..|..:.       |.|..:...:.||..:| |:.::        ..|.||
Human   588 GSDTEAQCEVMQEIVDQVLE-------EDFDSEQLSVLASCLQELFKAHF--------RGEVLP- 636

  Fly   640 QNIFSESKTEEKHLAKSISYPLYGLFRFL--YENDEKSKKPFQTLLSEICEGIPEIGYLLLYFMK 702
                 |..|||. |.:|:..|||.:||.|  .:.|..|......||||:.:..|:|||.|||:::
Human   637 -----EEITEES-LEESVGKPLYLIFRNLCQMQEDNSSFSLLLDLLSELYQKQPKIGYHLLYYLR 695

  Fly   703 IYCKLQTRKNSQQSYQFKTTIYRQICDAADEKIGNCLLRDLDLLEKENTNIFLWLLPDIYREFKS 767
            .......:.|..:|:...|    |:.|     :..||:.|:...::::..:...|.|.||.||..
Human   696 ASKAAAGKMNLYESFAQAT----QLGD-----LHTCLMMDMKACQEDDVRLLCHLTPSIYTEFPD 751

  Fly   768 IATNNTDLLRITLRCIDAKNVRDILYSIAQGKLTIFKQDGLIDCIRQSLEFETYEQFCLWQIVQA 832
            ....:.:||.:.:..||:..:::::..:..|.|.:|::|.:::.:.|||::||:||:|.||:..|
Human   752 ETLRSGELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQYCAWQLFLA 816

  Fly   833 HDVPLRCIQDILPELEAGSHPEALSHFLLLLKNEEPTNEIIRLMLSRESKSKGDPFVTSALRFWC 897
            |::||..|..||..|:...||||||..||.|:.|:|:.|:::::|||.. ...|.|.||.||.||
Human   817 HNIPLETIIPILQHLKYKEHPEALSCLLLQLRREKPSEEMVKMVLSRPC-HPDDQFTTSILRHWC 880

  Fly   898 QRYEEKLSEIIASLLTSKYPSSSPNKRKRPPKGISVSTSTP-----SADQVLNHLEHYRRSCRHG 957
            .:::|.|:|.|.|||...  :|.|.||:      |:.:|:.     :.:|:|.||::.|.:..:
Human   881 MKHDELLAEHIKSLLIKN--NSLPRKRQ------SLRSSSSKLAQLTLEQILEHLDNLRLNLTN- 936

  Fly   958 TGTGLYVHDMMQRALQSAYSHSNDSTKKQFCDLFALAAE-EDTTV----GRRGGSGRGRKQPGSK 1017
            |....:....:.:|||...:..:::.|.:|.|||:||.| ||::.    .||..:   ...|.|:
Human   937 TKQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSSTKPPKSRRKAA---LSSPRSR 998

  Fly  1018 KDVNNHGTSKKNPEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKAN----NDSD 1068
            |    :.|...|.|.    .|...::|||:.:|.|   ..||::|.:    :|||
Human   999 K----NATQPPNAEE----ESGSSSASEEEDTKPK---PTKRKRKGSSAVGSDSD 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS3	NP_001036437.1	Ints3_N	62..467	CDD:431123	227/405 (56%)
INTS3	NP_075391.3	Ints3_N	85..491	CDD:431123	227/405 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	976..1042		20/79 (25%)