Protein Alignment IntS3 and Ints3

DIOPT Version :10

• Sequence 1: NP_001036437.1
• Gene: IntS3 / 3355010
• FlyBaseID: FBgn0262117
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: XP_017446796.1
• Gene: Ints3 / 361988
• RGDID: 1304593
• Length: 1066
• Species: Rattus norvegicus
• Alignment Length: 1105
• Identity: 422/1105 - (38%)
• Similarity: 644/1105 - (58%)
• Gaps: 122/1105 - (11%)

  Fly    14 KLFICTAVDCKDDIEEKFERSFVTLQMQISGLSDKEMHDMLSQAVCK-EKQHEEISIGFLYIMLT 77
            :|.:.|::|.||::||:.||....:....:|:|::|.:|.|:..||| ..|||||.:|...::||
  Rat    34 RLLLSTSLDAKDELEERLERCMSIVTSMTAGVSEREANDALNAYVCKGPPQHEEICLGLFTLVLT 98

  Fly    78 DPSMASKTYRDVTLVSRDGMNGIVTNLTFLVAEKYTKLTEVARRQLIWLLREFVKHQVLSVENVI 142
            :|:.|.|.|||:.||||||||.::..:..|:.|||.||.:..|.||:||:||.||..||..:.|.
  Rat    99 EPAQAQKCYRDLALVSRDGMNIVLNKINQLLMEKYLKLQDTCRTQLVWLVRELVKSGVLGADGVC 163

  Fly   143 WNCLRQAGGGDVSSRNLFLIESLLDIFIEFRTWLETNPFLVQSTVYSFVRLIEDHANPA-LLSLR 206
            ...::|..||||:::|::|.||:|||..|.|.|:..:..|:...||:::|||.||...| |.:||
  Rat   164 MTFMKQIAGGDVTAKNIWLAESVLDILTEQREWVLKSSILIAMAVYTYLRLIVDHHGTAQLQTLR 228

  Fly   207 QKEVKFTISLIRERFHDIIPLGRDFVRLLQNVARIPEFEQLWRDILFNPKMLHQTFNGIWQLLHI 271
            ||||.|.|||:||||.:.:.:|||.||||||||||||||.||:||:.||:.|...|.||.|||..
  Rat   229 QKEVDFCISLLRERFMECLMIGRDLVRLLQNVARIPEFELLWKDIIHNPQALSPQFTGILQLLQS 293

  Fly   272 RTSRRFLQCRLLPEMERKISFLASSVKFGNQKRYQDWFQDKYFATPESHSLRSDLIRFIINVIHP 336
            ||||:||.|||.|:||.|:.|:.|.|:||.|||||||||.:|.:||:|.|||.||||:|..|:||
  Rat   294 RTSRKFLACRLTPDMETKLLFMTSRVRFGQQKRYQDWFQRQYLSTPDSQSLRCDLIRYICGVVHP 358

  Fly   337 TNDMLCSDIIPRWAIIGWLISSCTNPIASANAKLSLFYDWLFFDPAKDNIMNIEPGILVMYHSIR 401
            :|::|.|||:|||||||||:::||:.:|::||||:||||||||.|.||:||||||.||||:||::
  Rat   359 SNEVLSSDILPRWAIIGWLLTTCTSNVAASNAKLALFYDWLFFSPDKDSIMNIEPAILVMHHSMK 423

  Fly   402 NHPFVSSTLLDFLCRITKNFFVKHEDKIRIGVYNSLKLILEKQVIPNLQPLFESPKLDRELRNLI 466
            .||.:::|||||:|||..||:...|..:|.||::||..|:||:|:.:|.|||::||||:|||:::
  Rat   424 PHPAITATLLDFMCRIIPNFYPPLEGHVRQGVFSSLNHIVEKRVLAHLAPLFDNPKLDKELRSML 488

  Fly   467 RDNFREFLSPPANHGQLLFTSLHPVQGHILKKESDQRILHCENMDLHETGLINISGTIDEDKKIL 531
            |:.|.||.|.|:...:..|.....:.|              ......|:..:.....|:|
  Rat   489 REKFPEFCSSPSPPVEASFPEASGILG--------------STRGYQESFFLYSQVKIEE----- 534

  Fly   532 LVPTDQEIESVFSDETAENLRRVHNIEDN-----TDDDDDL------------PLSEVRLKEKPK 579
              |...|:::..||:.       .:..||     :||::||            |:.|..::|...
  Rat   535 --PVSMEMDNHLSDKD-------ESCYDNAEAAFSDDEEDLNSKGKKREFRFHPIKETVVEEPVD 590

  Fly   580 V-----ELAEAIAESFDAFVTKRNSYTWEAFLKDFRPLPASAFEE----FQLNYVISNTVLILR- 634
            |     :|.|::.:.  ....::.|.| ||..:..:.:.....||    .||:.:.|....:.:
  Rat   591 VTPYLDQLDESLRDK--VLQLQKGSDT-EAQCEVMQEIVDQVLEEDFDSEQLSVLASCLQELFKA 652

  Fly   635 ----ETLPQQNIFSESKTEEKHLAKSISYPLYGLFRFL--YENDEKSKKPFQTLLSEICEGIPEI 693
                |.||      |..|||. |.:|:..|||.:||.|  .:.|..|......||||:.:..|:|
  Rat   653 HFRGEVLP------EEVTEES-LEESVGKPLYLIFRNLCQMQEDNSSFSLLLDLLSELYQKQPKI 710

  Fly   694 GYLLLYFMKIYCKLQTRKNSQQSYQFKTTIYRQICDAADEKIGNCLLRDLDLLEKENTNIFLWLL 758
            ||.|||:::.......:.|..:|:...|    |:.|     :..||:.|:...::::..:...|.
  Rat   711 GYHLLYYLRASKAAAGKMNLYESFAQAT----QLGD-----LHTCLMMDMKACQEDDVRLLCHLT 766

  Fly   759 PDIYREFKSIATNNTDLLRITLRCIDAKNVRDILYSIAQGKLTIFKQDGLIDCIRQSLEFETYEQ 823
            |.||.||......:.:||.:.:..||:..:::::..:..|.|.:|::|.:::.:.|||::||:||
  Rat   767 PSIYTEFPDETLRSGELLNMIVAVIDSAQLQELVCHVMMGNLVMFRKDSVLNILIQSLDWETFEQ 831

  Fly   824 FCLWQIVQAHDVPLRCIQDILPELEAGSHPEALSHFLLLLKNEEPTNEIIRLMLSRESKSKGDPF 888
            :|.||:..||::||..:..||..|:...||||||..||.|:.|:|:.|:::::|||.. ...|.|
  Rat   832 YCAWQLFLAHNIPLETVIPILQHLKYKEHPEALSCLLLQLRREKPSEEMVKMVLSRPC-HPDDQF 895

  Fly   889 VTSALRFWCQRYEEKLSEIIASLLTSKYPSSSPNKRKRPPKGISVSTSTP-----SADQVLNHLE 948
            .||.||.||.:::|.|:|.|.:||...  :|.|.||:      |:.:|:.     :.:|:|.||:
  Rat   896 TTSILRHWCMKHDELLAEHIKALLIKN--NSLPRKRQ------SLRSSSSKLAQLTLEQILEHLD 952

  Fly   949 HYRRSCRHGTGTGLYVHDMMQRALQSAYSHSNDSTKKQFCDLFALAAE-EDTTVGRRGGSGRGRK 1012
            :.|.:..: |....:....:.:|||...:..:::.|.:|.|||:||.| ||::.          |
  Rat   953 NLRLNLAN-TKQNFFSQTPILQALQHVQASCDEAHKMKFSDLFSLAEEYEDSST----------K 1006

  Fly  1013 QPGS-KKDVNNHGTSKKN----PEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKAN----NDSD 1068
            .|.| :|...:...|:||    |...:.  |...::|||:.:|.|   ..||::|.:    :|||
  Rat  1007 PPKSRRKAALSSPRSRKNAAQPPNAEEE--SGSSSASEEEDTKPK---PTKRKRKGSSAVGSDSD 1066

  Fly  1069  1068
              Rat  1067  1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS3	NP_001036437.1	Ints3_N	62..467	CDD:431123	228/405 (56%)
Ints3	XP_017446796.1	Ints3_N	84..490	CDD:431123	228/405 (56%)