Protein Alignment IntS3 and ints-3

DIOPT Version :10

• Sequence 1: NP_001036437.1
• Gene: IntS3 / 3355010
• FlyBaseID: FBgn0262117
• Length: 1068
• Species: Drosophila melanogaster
• Sequence 2: NP_001293423.1
• Gene: ints-3 / 3565441
• WormBaseID: WBGene00022360
• Length: 1052
• Species: Caenorhabditis elegans
• Alignment Length: 1163
• Identity: 269/1163 - (23%)
• Similarity: 503/1163 - (43%)
• Gaps: 208/1163 - (17%)

  Fly     1 MEQQQSKNNAHVSKLF-ICTAVDCKDDIEEKFERSFVTLQMQISGLSDKEMHDMLSQAVCKEKQH 64
            |.:||::   .:.||. |....:...::..:.....:.|..:|:|.||||:.|::   :.|| :|
 Worm     1 MNEQQTR---RIQKLMKINLKCETPPELVARLANDSIVLDSRITGKSDKEVIDIM---ISKE-EH 58

  Fly    65 EEISIGFLYIMLT---DPSMASKTYRDVTLVSRDGMNGIVTNLTFLVAEKYTKLTEVARRQLIWL 126
            :..|||.:|.:||   :|.:..|..|.||....:..:.::.|:..::.|.:..|..:.:.||:.|
 Worm    59 DVKSIGLMYHILTSGENPDLFGKMIRYVTGGGAEYWHHVLCNMNMILFEVWPFLHLLCKEQLLRL 123

  Fly   127 LREFVKHQVLSVENVIWNCLRQA-GGGDVSSRNLFLIESLLDIFIEFRTWLETN---PFLVQSTV 187
            :||.|:..|..||||:.|..|.: |..|.:::....:: |..:..|...|.::.   ..||.:.:
 Worm   124 IREAVRQNVKQVENVLMNAFRMSIGSSDFATKQRIFMK-LNSMIRENEAWFKSQKACAALVANIL 187

  Fly   188 YSFVRLIEDHANPALLS----LRQKEVKFTISLIRERFHDIIPLGRDFVRLLQNVARIPEFEQLW 248
            .....:|  .::||.:|    .|:.::.....:|:.|..|.:.|||||:.:|..:.::|:.|::|
 Worm   188 TCTTSVI--ISSPAPISSQDTFRESQLDLVQWVIKSRKIDCLTLGRDFILILIRLGKMPQIEEIW 250

  Fly   249 RDILFNPKMLHQTFNGIWQLLHIRTSRRFLQ-CRLLPEMERKISFLASSVKFG-NQKRYQDWFQD 311
            :||:.||...     |:..|....|.:..|| .|:..|:|||:.|:.  |..| |...|..|..:
 Worm   251 KDIVANPASF-----GVSNLEEYMTKQNVLQHVRISIELERKVQFMV--VNGGKNLLTYFTWLNN 308

  Fly   312 KYFATPESHSLRSDLIRFIINV-IHPTNDM------------LCSDIIPRWAIIGWLISSCTNPI 363
            |:|...:..:||::.:|::::: :.|...:            |....:|....:.||
 Worm   309 KFFRANDGPALRAECVRYVLSMNLDPAKALPNAQENRVQLLHLLISTVPSGPELQWL-------- 365

  Fly   364 ASANAKLSLFYDWLFFDPAKD-NIMNIEPGILVMYHSIRNHP----------------FVSSTLL 411
                 ||.||.||...|.... |:|.:|....|:.:::...|                |.:| ||
 Worm   366 -----KLCLFADWFGCDDKNSANLMCVENSFSVVRYALFLTPTGPQQNSIVQGSHCSQFANS-LL 424

  Fly   412 DFLCRITKNFF-VKHEDKIRIGVYNSLKLILEKQVIPNLQPLFESPKLDRELRNLIRDNFREFLS 475
            :|||:...... ..:.:.||..|.::::.|.:: :..||..:.|:.|:||::..|:|:.|.:|:.
 Worm   425 EFLCKSVDVLLPPAYAEPIRRNVNSAMRFIKDR-LQHNLPQILENSKIDRKVSELLRNVFPDFVR 488

  Fly   476 PPANHGQLLFTSLHPVQGHILKKESDQRIL----HCENMDLHETGLINISGT--IDED--KKILL 532
            .|..:..::.............|.|.:..|    ..|........|.:.|.|  |:::  ||.:.
 Worm   489 NPIGNSSIIRPKKKSTDEEKAIKSSSEPALSEQKSTEKPSFSTEKLSSDSATTKIEKEKLKKAIE 553

  Fly   533 VPTDQEIESVFSDETAENLRRVHNIEDNTDDDDDLPLSEVRLKEKPKVELAEAIAESFDAFVTKR 597
            ...:||:..:......|...::..::|...:.||         :..|.|..|.:..|   .:|
 Worm   554 EQEEQELNVLIKQLQGEIGTKIAKLKDQWKEFDD---------DADKCEAVEGLLVS---LLT-- 604

  Fly   598 NSYTWEAFLKDFRPLPASAFEEFQLNYVISNTVLILRETLPQQNIFSESKTEEKHLAKSISYPLY 662
               |.:.|.:..:.|.|..     |..::.:.|...:..||         ..||.|:::.::|:|
 Worm   605 ---TGDVFDESQQELAAQC-----LLGIMGSVVADEQSLLP---------PNEKDLSEAFTHPIY 652

  Fly   663 GLFRFLY---ENDEKSKKPFQTLLSEICEGIPEIGYLLLYFMK----------IYCKLQTRKNSQ 714
            ...:.|.   :|||.|......:::.:.|....:.|:.|||:|          |.|
 Worm   653 SFLKVLCSPPDNDEASSDVMAAMMAAMREKDSSLTYVFLYFIKGTAGGRPTECIEC--------- 708

  Fly   715 QSYQFKTTIYRQICDAADEKIGNCLLRDLDLLEKENTNIFLWLLPDIYREFKSIATNNTDLLRIT 779
                     |:.|...:...:...|..||.|....:..:|.:|:|.::.:|:....:...||...
 Worm   709 ---------YKNIAKMSGRSVDEMLASDLQLCAVNDNRLFAYLVPFVFSQFEEEVMSTPALLATL 764

  Fly   780 LRCIDAKNVRDILYSIAQGKLTIFKQDGLIDCIRQSLEFETYEQFCLWQIVQAHDVPLRCIQDIL 844
            ...:||..:|..:..|.:.::.||:::.....:..|:::.|..|:..|.:|.|..||:......:
 Worm   765 CANLDAIQLRSFVSEIIREEIKIFRKESFPKMVMDSVDWATTPQWVFWHLVHADGVPIEWFLSTI 829

  Fly   845 PELEAGSHPEALSHFLLLLK--NEEPTNEIIRLMLSRESKSKGDPFVTSALRFWCQRYE--EKLS 905
            |:.:|..|.||:::.||::|  :.||...:||.:.:| ..:|.|.|...|::...:..|  :|::
 Worm   830 PKFDAVGHDEAIANILLMMKRMDREPWAGLIRALFNR-VPNKDDTFTIDAMKVLIEDSEQCQKVA 893

  Fly   906 EIIASLLTSKYPSSS-------PNKRKRPPKGISVSTSTPSADQVLNHLEHYRRSC----RHGTG 959
            ||:|.|:.....::.       .:|:..|.|        .:..|||.||:|:..:|    :..|.
 Worm   894 EIVAQLIKKLLGNNDIIGLGVRVHKKGNPMK--------LTLQQVLEHLQHFSSTCVEKKQRMTE 950

  Fly   960 TGLYVHDMMQRA-LQSAYSHSNDSTK-----KQFCDLFAL--AAEEDTTVGRRGGSGRGRKQPGS 1016
            |      .|.|: ||.|::....:.|     |::.:||..  ...:||.......:.||.:|
 Worm   951 T------FMSRSHLQEAFASIKVNDKAVVLVKKYGNLFGAMDIIAQDTKEHSSSRTLRGNRQ--- 1006

  Fly  1017 KKDVNNHGTSKKNPEMVKTIYSSDDNSSEEDWSKSKILQTAKRRKKANN------DSD 1068
                   |||.:..:| :.::......:|:|      .|.:|:||..||      |||
 Worm  1007 -------GTSAERQQM-QQMHHQKRKPNEDD------EQNSKKRKMHNNIIELSDDSD 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IntS3	NP_001036437.1	Ints3_N	62..467	CDD:431123	112/448 (25%)
ints-3	NP_001293423.1	Ints3_N	56..481	CDD:431123	113/450 (25%)