DRSC/TRiP Functional Genomics Resources

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Protein Alignment rl and CDK17

DIOPT Version :10

Sequence 1:NP_001015122.1 Gene:rl / 3354888 FlyBaseID:FBgn0003256 Length:376 Species:Drosophila melanogaster
Sequence 2:NP_002586.2 Gene:CDK17 / 5128 HGNCID:8750 Length:523 Species:Homo sapiens


Alignment Length:350 Identity:126/350 - (36%)
Similarity:185/350 - (52%) Gaps:32/350 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 RGQIFEVG----PRYIKLAYIGEGAYGMVVSADDTLTNQRVAIKKISPFEHQTYCQRT-LREITI 87
            |..:.|:|    ..||||..:|||.|..|......||...||:|:|. .||:.....| :||:::
Human   178 RASLSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIR-LEHEEGAPCTAIREVSL 241

  Fly    88 LTRFKHENIIDIRDILRVDSIDQMRDVYIVQCLMETDLYKLLKT--QRLSNDHICYFLYQILRGL 150
            |...||.||:.:.||:..|     :.:.:|...::.||.:.:..  ..:|..::..|||||||||
Human   242 LKDLKHANIVTLHDIVHTD-----KSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRGL 301

  Fly   151 KYIHSANVLHRDLKPSNLLLNKTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 215
            .|.|...||||||||.|||:|:..:||:.||||||.....   |...:..|.|.|||.|:::|.|
Human   302 AYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVP---TKTYSNEVVTLWYRPPDVLLGS 363

  Fly   216 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSRDDLECI-INEKARNYLES 279
            ..|:..||:|.||||..||.|.||:|||....|:|:.|..:||:||::....| .||:.:||  :
Human   364 SEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNEEFKNY--N 426

  Fly   280 LP-FKPNVPWAKLFPNADALALDLLGKMLTFNPHKRIPVEEALAHPYLEQYYDPGDEPVAEVPFR 343
            .| :||. |.....|..|:..::|:.|.|.:...||:..|||:.|.|... ..|          |
Human   427 FPKYKPQ-PLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRS-LGP----------R 479

  Fly   344 INMENDDISRDALKSLIFEETLKFK 368
            |:...:.:|..:||.:..::...|:
Human   480 IHALPESVSIFSLKEIQLQKDPGFR 504

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
rlNP_001015122.1 STKc_ERK1_2_like 32..366 CDD:270839 124/342 (36%)
CDK17NP_002586.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 30..55
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 103..123
STKc_PCTAIRE2 185..493 CDD:143377 121/330 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..523 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

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