DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3347 and KDM7A

DIOPT Version :9

Sequence 1:	NP_001285579.1	Gene:	CG3347 / 33538	FlyBaseID:	FBgn0031513	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_085150.1	Gene:	KDM7A / 80853	HGNCID:	22224	Length:	941	Species:	Homo sapiens

Alignment Length:	610	Identity:	124/610 - (20%)
Similarity:	200/610 - (32%)	Gaps:	185/610 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GEADTAVSSKDVYCICRQSH-INGFMICCDNCNEWFHGDCIGLPANIGEQHDTYYCTEC------ 68
            |.|........|||:|||.: :|.|||.||.|.:||||.|:|:..:.....|.|:|..|
Human    27 GRASAPPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHGS 91

  Fly    69 --------FRKNPLLKCTYKKSPSTTGVPKTPKTPKTPKTPKN---------------------- 103
                    :.::...:......|...|.....|..::...|..
Human    92 SLMKKRRNWHRHDYTEIDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGF 156

  Fly   104 ------PKTPKTPKNSKTPKTA-----------RIINSIGVRQNPRRRSTFVQERPSEVPNPSRQ 151
                  ||.........:|..:           ::|:.|.|.:....:.| :........||:|
Human   157 DVPIMVPKLDDLGLRLPSPTFSVMDVERYVGGDKVIDVIDVARQADSKMT-LHNYVKYFMNPNR- 219

  Fly   152 STKLQKAVNYENATEEPTEDAEKVDQKPKKTAKKKN--------PKP----------EDKVTD-- 196
             .|:...::.|.:..:.:|..| |....||.:..:|        |||          :|..||
Human   220 -PKVLNVISLEFSDTKMSELVE-VPDIAKKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFH 282

  Fly   197 -DAQKPAV-------EKLFE-SKGTQCNM--FRDWSKYVPPENSKKRGTCFTVFCQQLARSCSRY 250
             |....:|       ||:|. .|.|..|:  :..||..|         |...||.......|.:
Human   283 IDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSV---------TQSEVFFGDKVDKCYK- 337

  Fly   251 CCDECGNFTAITNVFALGLLPNMPAMKVAMGHVGLLLGNDLTN-NQKSNKNSEASESKTETKPKV 314
            |..:.|:...:...:...:|.:...|  |.|      ||.|.| |..........|.:.:|....
Human   338 CVVKQGHTLFVPTGWIHAVLTSQDCM--AFG------GNFLHNLNIGMQLRCYEMEKRLKTPDLF 394

  Fly   315 KKPKSEGRKSRYRSPSSSLERSPDVSRTAAKRPKLQEELPSSSSRSSRKLVEESRSETERH---- 375
            |.|..|.                 :....||  .|.|.|         |.:.|...:.:.:
Human   395 KFPFFEA-----------------ICWFVAK--NLLETL---------KELREDGFQPQTYLVQG 431

  Fly   376 -KAKHKTSK---KEKTSSQRAYSLSPIPSPKSYRAARNTSETAPNSPVNLKKTFKQKHVISSPTG 436
             ||.|...|   |::..|:.|:.:                      |.|:    :..|:|..
Human   432 VKALHTALKLWMKKELVSEHAFEI----------------------PDNV----RPGHLIKE--- 467

  Fly   437 KKRVCRSQTISADDPLPSQPKSTEVSPMASAGTSSSNKKPVPETSCQKYRKLS----FTDENCEK 497
                 .|:.|.|.:....:|..::..|:....:.|||:...|..|.:|.|||.    .|..|.:.
Human   468 -----LSKVIRAIEEENGKPVKSQGIPIVCPVSRSSNEATSPYHSRRKMRKLRDHNVRTPSNLDI 527

  Fly   498 IKI-IRCIVS--NMSPTEKALLARK 519
            ::: .|.::.  .|.|.|:.:|:.|
Human   528 LELHTREVLKRLEMCPWEEDILSSK 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3347	NP_001285579.1	PHD_SF	23..68	CDD:304600	21/45 (47%)
KDM7A	NP_085150.1	PHD_KDM7	39..88	CDD:277110	22/48 (46%)
		Linker	97..114		0/16 (0%)
		JmjC	234..297	CDD:214721	14/63 (22%)
		cupin_like	269..369	CDD:304367	25/117 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..633
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	677..700
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..921
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900