DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3347 and Dido1

DIOPT Version :9

Sequence 1:	NP_001285579.1	Gene:	CG3347 / 33538	FlyBaseID:	FBgn0031513	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	NP_780760.2	Gene:	Dido1 / 23856	MGIID:	1344352	Length:	2256	Species:	Mus musculus

Alignment Length:	718	Identity:	142/718 - (19%)
Similarity:	219/718 - (30%)	Gaps:	302/718 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VYCICRQSHINGFMICCDNCNEWFHGDCIGLPANIG----EQHDTYYCTECFRKNPLLK------ 76
            :||||||.|.|.||||||.|.|||||||:|:....|    ...:.|.|..|    .:|:
Mouse   266 LYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNC----TILQVQDETN 326

  Fly    77 --------------------CT-----YKKSPSTTGV-------------------------PKT 91
                                ||     .:||....|:                         |..
Mouse   327 GSATDEQDSGCRSVGADGTDCTSIGTVEQKSGEDQGIKGRIEKAANPSGKKKLKIFQPVVEAPGA 391

  Fly    92 PK----------------------------------TPKTPKTPKNPKTPKTPKNSKTPKTARII 122
            ||                                  :.|..||....|....|:....||.:
Mouse   392 PKCIGPGCSSVAQPDSVYCSNDCILKHAAATMRFLSSGKEQKTKPKEKVKTKPEKFSLPKCS--- 453

  Fly   123 NSIGV-------------RQNP-------RRRSTFVQERPSEVPNPSRQS--------------- 152
            ..:|:             |:||       .|..|..:|...|...||..|
Mouse   454 VQVGIKISSVHKRLASEKRENPVKKVMLASRSETSGKEAACESSTPSWASDHNYNAVKPEKPEKP 518

  Fly   153 -----TKLQKAVNYENATEEPTEDAEKVDQK-------------PKKTAKKKNPKPEDKVTDDAQ 199
                 |.|.|::..:...|:.|..|..:.:|             |:....||.| |...:.  ..
Mouse   519 TALSPTLLSKSMKDDRRVEDRTMAAVTIPKKALPSASLVGRQTSPRNLVPKKLP-PYSNMA--GA 580

  Fly   200 KPAVEKLFES-KGTQCNMFRDW-SKYVPPENSKKRG-TCFTVFCQQLARSCSRYCCDECGNFTAI 261
            |||::||... |||...  |.| |..:...::::.| |..|...::|..|            .|:
Mouse   581 KPAIKKLPSGFKGTIPK--RPWPSATLSGTSARQAGPTPMTAASKKLPGS------------AAV 631

  Fly   262 TNVFALGLLPNMPAMKVAMGHVGLLLG-------------------------ND-----LTNN-- 294
            ..|....:..|:||...|.|.:|.:..                         ||     :|.|
Mouse   632 VGVTRKPMSANVPAASPAPGRLGPVSPAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEV 696

  Fly   295 -------QKSNKN-SEASESKTETKPK-----VKKPKSEGRKSRYRSPSSSLER----SPDVSRT 342
                   :|...| .:.::::.::|.:     :|.||::|...|......||.:    .|:  ..
Mouse   697 GKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRMKPE--EL 759

  Fly   343 AAKRPKLQEELPSSSSRSSR-KLVEESRSETER-----------------------HKAKHKTSK 383
            .:|...:..|.|:.|...|| ||:.||:..|.:                       ..|..|::.
Mouse   760 VSKELSMWTEKPTKSVIESRTKLLNESKKNTTKPETIPDMEDSPPVSDSEEQQESVRAAPEKSAA 824

  Fly   384 ----------KEKTSSQRAY--------------SLSPIPSPKSYRAARNTSETAPNSPVNLKKT 424
                      |:.||..||:              |....|:||..:.:.::.          |:.
Mouse   825 PLLDVFSSMLKDTTSQHRAHLFDLNCKICTGQVPSSEDEPAPKKQKLSASSK----------KED 879

  Fly   425 FKQKHVISSP-----TGKKRVCRSQTISADDP--------------LPSQPKSTEVSPMASAGTS 470
            ||.:|..|.|     |..:.:..:...:|.:|              .|..|..:...|.:..|.|
Mouse   880 FKPRHDSSPPNAVPNTADEGIADTLPENASEPDPESTSSLNQERKCFPESPGDSHPEPSSLGGLS 944

  Fly   471 SSN 473
            .|:
Mouse   945 PSS 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3347	NP_001285579.1	PHD_SF	23..68	CDD:304600	26/48 (54%)
Dido1	NP_780760.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..256
		TNG2	<157..299	CDD:227367	23/32 (72%)
		Nuclear localization signal. /evidence=ECO:0000255	162..170
		Nuclear localization signal. /evidence=ECO:0000255	182..190
		PHD_DIDO1_like	263..316	CDD:277109	26/49 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..535		10/53 (19%)
		PHA03247	<483..663	CDD:223021	43/196 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	598..624		6/25 (24%)
		PRK14954	<600..>665	CDD:184918	15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	641..668		6/26 (23%)
		TFS2M	669..770	CDD:128786	16/102 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	778..822		8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..970		19/102 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1011..1039
		SPOC	1045..1190	CDD:369497
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1197..1218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1288
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1320..1347
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1362..1421
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1509..1609
		PHA03247	<1571..2083	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1630..2256
		SF-CC1	2142..>2180	CDD:273721
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900