Protein Alignment CG3347 and DIDO1

DIOPT Version :10

• Sequence 1: NP_722887.2
• Gene: CG3347 / 33538
• FlyBaseID: FBgn0031513
• Length: 538
• Species: Drosophila melanogaster
• Sequence 2: NP_149072.2
• Gene: DIDO1 / 11083
• HGNCID: 2680
• Length: 2240
• Species: Homo sapiens
• Alignment Length: 655
• Identity: 136/655 - (20%)
• Similarity: 215/655 - (32%)
• Gaps: 219/655 - (33%)

  Fly    22 VYCICRQSHINGFMICCDNCNEWFHGDCIGLPANIG----EQHDTYYCTECF------------- 69
            :||||||.|.|.||||||.|.|||||||:|:....|    ...:.|.|..|.
Human   269 LYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETHSETA 333

  Fly    70 ---------------------------------------RKNPLLK------------------- 76
                                                   ..||..|
Human   334 DQQEAKWRPGDADGTDCTSIGTIEQKSSEDQGIKGRIEKAANPSGKKKLKIFQPVIEAPGASKCI 398

  Fly    77 ------------------CTYKKSPST-----TGVPKTPKTPKTPKTPKNPKTPKTPKNSKTPKT 118
                              |..|.:.:|     :|..:.|| || .|....|:.|..||..  .:.
Human   399 GPGCCHVAQPDSVYCSNDCILKHAAATMKFLSSGKEQKPK-PK-EKMKMKPEKPSLPKCG--AQA 459

  Fly   119 ARIINSIGVRQNPRRRSTFVQERPSEVPNPSRQSTKLQKAVNYENATEEPTEDAEKVDQKPKKTA 183
            ...|:|:..|..|.::.|.|::   .|..|:| |..|.|....|::|.....|......||:|||
Human   460 GIKISSVHKRPAPEKKETTVKK---AVVVPAR-SEALGKEAACESSTPSWASDHNYNAVKPEKTA 520

  Fly   184 ----------KKKNPKPEDKVTDDA-------------QKPAVEKLFESKGTQCNMF-------- 217
                      .|::.:.|:|....|             ::||...|...|.:..|:.
Human   521 APSPSLLYKSTKEDRRSEEKAAAMAASKKTAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKK 585

  Fly   218 -----------RDWSKYVPPEN---SKKRGTCFTVFCQQLARSCSRYCCDECGNFTAITNVFALG 268
                       |.|....|...   :::.|.         |.:.:.....:.....|:.......
Human   586 PPSGFKGTIPKRPWLSATPSSGASAARQAGP---------APAAATAASKKFPGSAALVGAVRKP 641

  Fly   269 LLPNMPAMKVAMGHVGLLLGNDLTNNQKSNKNSEA------------SESKTETKPKVKK----- 316
            ::|::|....|.|.:|.:.......|.:..:|...            |:....|:.:|.|
Human   642 VVPSVPMASPAPGRLGAMSAAPSQPNSQIRQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHI 706

  Fly   317 --------PKSEGR-KSRYRS-------PSSS------LERSPDVSRTAAKRPK--LQEELPSSS 357
                    ..::.| ||:|||       |.:.      |.....:::....:|:  :.:||.:..
Human   707 EKEMFNLFQVTDNRYKSKYRSIMFNLKDPKNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWK 771

  Fly   358 SRSSRKLVEESRSETERHKAKHKTSKKEKTSSQRAYSLSPIPSPKSYRAARNTSE--TAPNSPV- 419
            .|.:|.::|   |.|:.|....||:.:::.......|.....|.:...:||...|  |||...|
Human   772 ERPARSVME---SRTKLHNESKKTAPRQEAIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVF 833

  Fly   420 --NLKKTFKQ--KHVISSPTGKKRVCRSQTISA-DDPLPSQPK---STEVSPMASAGTSSSNKKP 476
              .||.|..|  .|:...   ..::|..|..|| |:|.|.:.|   |.:...:.|...||: ..|
Human   834 SSMLKDTTSQHRAHLFDL---NCKICTGQVPSAEDEPAPKKQKLSASVKKEDLKSKHDSSA-PDP 894

  Fly   477 VPETS 481
            .|:::
Human   895 APDSA 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3347	NP_722887.2	PHD_SF	23..68	CDD:473978	26/48 (54%)
DIDO1	NP_149072.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..259
		TNG2	<160..302	CDD:227367	23/32 (72%)
		Nuclear localization signal. /evidence=ECO:0000255	165..173
		Nuclear localization signal. /evidence=ECO:0000255	185..193
		PHD_DIDO1_like	266..319	CDD:277109	26/49 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..456		10/26 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	501..567		13/65 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	584..618		4/42 (10%)
		TFS2M	672..773	CDD:128786	16/100 (16%)
		PHA03247	<773..1044	CDD:223021	36/134 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	773..826		13/55 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	860..947		12/41 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1013..1045
		SPOC_DIDO1-like	1056..1198	CDD:439210
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1206..1427
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1453..1472
		SWIRM-assoc_1	<1469..1507	CDD:465142
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1517..2240
		PHA03247	<1525..2054	CDD:223021
		SF-CC1	2125..>2230	CDD:273721