DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3347 and DIDO1

DIOPT Version :9

Sequence 1:	NP_001285579.1	Gene:	CG3347 / 33538	FlyBaseID:	FBgn0031513	Length:	538	Species:	Drosophila melanogaster
Sequence 2:	XP_011526806.1	Gene:	DIDO1 / 11083	HGNCID:	2680	Length:	2276	Species:	Homo sapiens

Alignment Length:	691	Identity:	134/691 - (19%)
Similarity:	216/691 - (31%)	Gaps:	255/691 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VYCICRQSHINGFMICCDNCNEWFHGDCIGLPANIG----EQHDTYYCTEC-------------- 68
            :||||||.|.|.||||||.|.|||||||:|:....|    ...:.|.|..|
Human   269 LYCICRQPHNNRFMICCDRCEEWFHGDCVGISEARGRLLERNGEDYICPNCTILQVQDETHSETA 333

  Fly    69 ---------------------------------------------------FRKNP--------- 73
                                                               |:..|
Human   334 DQQEAKWRPGDADGTDCTSIGTIEQKSSEDQGIKGRIEKAANPSGKKKLKIFQPGPGPVPTQLPV 398

  Fly    74 --------------------LLKCTYKKSPS---------------------------------- 84
                                .:.|...::|.
Human   399 LWQVLEIAVSRSISAFTLLHCISCKVIEAPGASKCIGPGCCHVAQPDSVYCSNDCILKHAAATMK 463

  Fly    85 --TTGVPKTPKTPKTPKTPKNPKTPKTPKNSKTPKTARIINSIGVRQNPRRRSTFVQERPSEVPN 147
              ::|..:.|| || .|....|:.|..||..  .:....|:|:..|..|.::.|.|::   .|..
Human   464 FLSSGKEQKPK-PK-EKMKMKPEKPSLPKCG--AQAGIKISSVHKRPAPEKKETTVKK---AVVV 521

  Fly   148 PSRQSTKLQKAVNYENATEEPTEDAEKVDQKPKKTA----------KKKNPKPEDKVTDDA---- 198
            |:| |..|.|....|::|.....|......||:|||          .|::.:.|:|....|
Human   522 PAR-SEALGKEAACESSTPSWASDHNYNAVKPEKTAAPSPSLLYKSTKEDRRSEEKAAAMAASKK 585

  Fly   199 ---------QKPAVEKLFESKGTQCNMF-------------------RDWSKYVPPEN---SKKR 232
                     ::||...|...|.:..|:.                   |.|....|...   :::.
Human   586 TAPPGSAVGKQPAPRNLVPKKSSFANVAAATPAIKKPPSGFKGTIPKRPWLSATPSSGASAARQA 650

  Fly   233 GTCFTVFCQQLARSCSRYCCDECGNFTAITNVFALGLLPNMPAMKVAMGHVGLLLGNDLTNNQKS 297
            |.         |.:.:.....:.....|:.......::|::|....|.|.:|.:.......|.:.
Human   651 GP---------APAAATAASKKFPGSAALVGAVRKPVVPSVPMASPAPGRLGAMSAAPSQPNSQI 706

  Fly   298 NKNSEA------------SESKTETKPKVKK-------------PKSEGR-KSRYRS-------P 329
            .:|...            |:....|:.:|.|             ..::.| ||:|||       |
Human   707 RQNIRRSLKEILWKRVNDSDDLIMTENEVGKIALHIEKEMFNLFQVTDNRYKSKYRSIMFNLKDP 771

  Fly   330 SSS------LERSPDVSRTAAKRPK--LQEELPSSSSRSSRKLVEESRSETERHKAKHKTSKKEK 386
            .:.      |.....:::....:|:  :.:||.:...|.:|.::|   |.|:.|....||:.:::
Human   772 KNQGLFHRVLREEISLAKLVRLKPEELVSKELSTWKERPARSVME---SRTKLHNESKKTAPRQE 833

  Fly   387 TSSQRAYSLSPIPSPKSYRAARNTSE--TAPNSPV---NLKKTFKQ--KHVISSPTGKKRVCRSQ 444
            .......|.....|.:...:||...|  |||...|   .||.|..|  .|:...   ..::|..|
Human   834 AIPDLEDSPPVSDSEEQQESARAVPEKSTAPLLDVFSSMLKDTTSQHRAHLFDL---NCKICTGQ 895

  Fly   445 TISA-DDPLPSQPK---STEVSPMASAGTSSSNKKPVPETS 481
            ..|| |:|.|.:.|   |.:...:.|...||: ..|.|:::
Human   896 VPSAEDEPAPKKQKLSASVKKEDLKSKHDSSA-PDPAPDSA 935

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3347	NP_001285579.1	PHD_SF	23..68	CDD:304600	26/48 (54%)
DIDO1	XP_011526806.1	TNG2	<160..302	CDD:227367	23/32 (72%)
		PHD_DIDO1_like	266..319	CDD:277109	26/49 (53%)
		TFS2M	708..809	CDD:128786	16/100 (16%)
		SPOC	1093..1199	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1632
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900