DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and Rapgef2

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_011238578.1	Gene:	Rapgef2 / 76089	MGIID:	2659071	Length:	1657	Species:	Mus musculus

Alignment Length:	484	Identity:	91/484 - (18%)
Similarity:	176/484 - (36%)	Gaps:	151/484 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 STDS-ESADECGLELGESGADSREAGAGGGAGLQVAQGGIFSLDPGHL--TAETALLG------- 114
            |.|| ..|.|.||:.|:   ...|........:|:::......:..||  |.:|.|..
Mouse   576 SVDSCSKATEAGLKRGD---QILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLFVFKELLTR 637

  Fly   115 ---------------GNIRYRRRHSAEQLSAYDLE--MGFQQL-ELGTTISVGPKNE-----DLV 156
                           |:|:...|:|...| |.|:|  :|.::: :.....:||.:|:     |..
Mouse   638 LSEEKRNGAPHLPKIGDIKKASRYSIPDL-AVDVEQVIGLEKVNKKSKANTVGGRNKLKKILDKT 701

  Fly   157 QYDV-PKNPHKRSQCDINFESSVLGSGGIMYINGRI-VSGPLDS----LIET------------- 202
            :..: |:.|:.......:.:.|::|.....:|...: |||.|.|    |:::
Mouse   702 RISILPQKPYNDIGIGQSQDDSIVGLRQTKHIPAALPVSGTLSSSNPDLLQSHHRILDFSTTPDL 766

  Fly   203 -----------------LLPKD------VVDLDKEFVFS-----FLLSCRLFLRPHELL--GRLL 237
                             ::.||      |:...:||..:     :.| |.:.:.|..::  .||.
Mouse   767 PDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTATPEQYSL-CEVSVTPEGVIKQRRLP 830

  Fly   238 DSVPESECLESLVSLLAEWTMKFPYDYRDERMMSHVKHIVARCSNSHLEAAVSQTLSALLKRLTD 302
            |.:.:   |...:.|...:.:|  .:...|.:          ||:...:..:.::..:||:..|.
Mouse   831 DQLSK---LADRIQLSGRYYLK--NNMETETL----------CSDEDAQELLRESQISLLQLSTV 880

  Fly   303 LERHEADLRACQTNDKSGPETPLNCPTATQYAQIVCRVEKKLAKHIGGEEFLQCSSMILLDKQKK 367
            ....:..:|..:......|         |:|...:.:::.|.:          |:::      ||
Mouse   881 EVATQLSMRNFELFRNIEP---------TEYIDDLFKLKSKTS----------CANL------KK 920

  Fly   368 WDQPSTSGAPPGAQDPKKTCNLETYLDWSARLRLFVCNEILQSVGIEGRSRTVELWSGVAQYCLL 432
            :::               ..|.||:  |       |.:|||:......|.:.::.:..:|.:|..
Mouse   921 FEE---------------VINQETF--W-------VASEILRETNQLKRMKIIKHFIKIALHCRE 961

  Fly   433 VGNYNSATAILESLESPAIARLKITWSKL 461
            ..|:||..||:..|....:|||:.||.||
Mouse   962 CKNFNSMFAIISGLNLAPVARLRTTWEKL 990

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	22/150 (15%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	28/128 (22%)
Rapgef2	XP_011238578.1	CAP_ED	37..143	CDD:237999
		cNMP	297..412	CDD:197516
		RasGEFN	428..541	CDD:214571
		PDZ_signaling	545..625	CDD:238492	13/51 (25%)
		degP_htrA_DO	<565..689	CDD:273938	24/116 (21%)
		RA_PDZ-GEF1	769..851	CDD:340483	14/87 (16%)
		RasGEF	874..1099	CDD:238087	35/166 (21%)
		PHA03379	<1522..>1643	CDD:223066
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910