DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34393 and rgl2

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_005158441.1	Gene:	rgl2 / 65227	ZFINID:	ZDB-GENE-010131-1	Length:	744	Species:	Danio rerio

Alignment Length:	510	Identity:	111/510 - (21%)
Similarity:	176/510 - (34%)	Gaps:	133/510 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 SADECGLELGESGADSREAGAGGGAGLQVAQGGIFSLDPGHLTAETALLGGNIRYRRRHSAEQLS 129
            |....|::|  .|...||....|...||....|    .|..|..|:     ..|....|:..:.|
Zfish     5 SMKSSGVDL--PGVGPREVPLIGYRALQTELDG----SPDQLWKES-----EHREADHHTQGEPS 58

  Fly   130 AYDLEMGFQQLELGTTISVGPKNEDLVQYDV-----------PKNPHKRSQCDINFESSVLGSGG 183
            ...... :..|:|.|   |....||.:.|.|           |::...|||
Zfish    59 PMKTTW-YCPLDLST---VSEMEEDGIIYTVVVKQGPGSPTSPQSTAARSQ-------------- 105

  Fly   184 IMYINGRIVSGPLDSLIETLLPKDVVDLDKEFVFSFLLSCRLFLRPHELLGRL---LDSVP-ESE 244
                  .:.:|..:.|:..||....:. |..|:..||.:.|.|.....:|..|   |::.| ||.
Zfish   106 ------HVKAGTEEKLVLHLLHSFSMG-DSSFISIFLSTYRSFTSTQRVLDILICRLENPPGESH 163

  Fly   245 C------LESLVSLLAEWTMKFPYDYRDERMMSHVKHIVARCSNSHLEAAVSQTLSALLKRLTDL 303
            .      .:::.::.:.|...:|.|:|.....|.:..:..........|.:...|..:.:.|::.
Zfish   164 SNSRQMFNKAVCTVFSTWMTDYPEDFRSLSDPSRLLRLAPLLPTDSSGAEIKSRLLRIAEELSEK 228

  Fly   304 ERHEADLRACQTNDKSGPETP--------LNCPTATQYAQIVCRVEK----KLAKHIGGEEFLQC 356
            ....|.| :..|.....|..|        |..|::. .|:.:.|:|.    ||..|       .|
Zfish   229 TLLSASL-SDPTKGLLSPPNPSDFDATSVLGFPSSV-IAEQLTRIETDLFLKLVPH-------HC 284

  Fly   357 SSMILLDKQKKWDQPSTSGAPPGAQDPKKTCNLETYLDWSARLRLFVCNEILQSVGI-------- 413
            ...:...:.||..:        ||      |       ||.|..:...|.:..:|..
Zfish   285 LGSLWSQRDKKGQE--------GA------C-------WSVRATIKQFNRLANAVTASCLWMTTL 328

  Fly   414 --EGRSRTVELWSGVAQYCLLVGNYNSATAILESLESPAIARLKITWSKLQVTCQQLD--CMQRH 474
              :.|:|.:|.|..||:.|....|::|..|||.:|:|..|.||:.||       |:.|  .::|:
Zfish   329 KSQQRARLLEKWISVAEACRTRKNFSSLYAILSALQSNPIHRLRKTW-------QETDREAVKRY 386

  Fly   475 AEGHGHLWQKQAISLNEQ---QEGLKTDKQAPKE----------PAAQGAAPTQG 516
            .|......:|...|.:.:   :||  |.|.|..:          ..|||..|..|
Zfish   387 EELSDIFSEKDNYSQSRELLKEEG--TSKFANHDTKINNRRFTGSCAQGTVPYLG 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	22/113 (19%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	38/154 (25%)
rgl2	XP_005158441.1	REM	111..>190	CDD:100121	18/79 (23%)
		RasGEF	256..519	CDD:214539	54/222 (24%)
		UBQ	626..710	CDD:294102
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910