DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and Rapgef3

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_038935756.1	Gene:	Rapgef3 / 59326	RGDID:	621869	Length:	1003	Species:	Rattus norvegicus

Alignment Length:	474	Identity:	98/474 - (20%)
Similarity:	160/474 - (33%)	Gaps:	139/474 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RDRDKCHHGHHQHHRRHHRRRCRISSNSSSTDSESADECGLELGESGADSREAGAGGGAGLQVAQ 95
            |||        ::|.|.||:.|        :..|..|.. |.|| .|..||....|      :.|
  Rat   148 RDR--------KYHLRLHRQCC--------SGRELVDGI-LALG-LGVHSRSQAVG------ICQ 188

  Fly    96 GGIFSLDPG---HLTAETALLGGNIRYRRRHSAEQLSAYDLEMGFQQLELGTTISV-GPKNEDLV 156
               ..||.|   |:..:......:.::.|....|...|...::..:.:|....:|. ||  :.|:
  Rat   189 ---VLLDEGALCHVKHDWTFQDRDAQFYRFPGPEPQPAGTHDVEEELVEAMALLSQRGP--DALL 248

  Fly   157 QYDVPKNPHKRS--QCDINFESSVLGSGGIMYINGRIVSGPLDSLIETLLPKDVVDLDKEFVFSF 219
            ...:.|:|.:|:  :.|:.||                         |.|..|.|..|.......
  Rat   249 TVALRKSPGQRTDEELDLIFE-------------------------ELLHIKAVAHLSNSVKRE- 287

  Fly   220 LLSCRLFLRPHELLGRLLDSVPESECL---------------ESLVSLLAEWTMKFPYDYRDERM 269
             |:..|...||...|.:|.|..:....               :.||:.|.|..     |:....:
  Rat   288 -LAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGD-----DFGQLAL 346

  Fly   270 MSHVKH---IVARCSNSHLEAAVSQTLSALLK----RLTDLERH-EADLRACQTNDKSGPETPLN 326
            ::....   |:.|.:|.|......|..:.::|    :...||.| :..|...:|:..:||..| .
  Rat   347 VNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRP-P 410

  Fly   327 CPTATQYAQIVCRVEKKL-----------AKHIGGEEFLQ-----------CSSMILLDKQKKWD 369
            .|...:|..:....||.|           :.|...|.||.           |:.:..........
  Rat   411 TPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPCTQLFAALLHHFHV 475

  Fly   370 QPSTSGAPPGAQDPKKTCNLETYLDWSARLRLFVCNEILQSVGIEGRSRTVELWSGVAQYCLLVG 434
            :||   .|.|..:.:::    ||          :||:..|.:      |.|..|  ||.|..::.
  Rat   476 EPS---EPAGGSEQERS----TY----------ICNKRQQIL------RLVSRW--VALYSPMLR 515

  Fly   435 NYNSATAILESLESPAIAR 453
            :...||:.|:.| |..::|
  Rat   516 SDPVATSFLQKL-SDLVSR 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	23/125 (18%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	29/142 (20%)
Rapgef3	XP_038935756.1	DEP_Epac	131..254	CDD:239884	30/134 (22%)
		CAP_ED	278..387	CDD:237999	19/115 (17%)
		RasGEF_N	418..527	CDD:395493	26/133 (20%)
		RasGEF	738..1003	CDD:214539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910