DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34393 and RALGDS

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_006257.1	Gene:	RALGDS / 5900	HGNCID:	9842	Length:	914	Species:	Homo sapiens

Alignment Length:	650	Identity:	127/650 - (19%)
Similarity:	206/650 - (31%)	Gaps:	176/650 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 IVSGPLDSLIETLLPKDVVDLDKEFVFSFLLSCRLFLRPHELLGRLL------------------ 237
            :.:|.|:.|:|.|:|. ....|..:|..||.:.|.|....::|..|.
Human   116 VKAGTLEKLVEHLVPA-FQGSDLSYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCI 179

  Fly   238 ------DSVPESECLESLVSLLAEWTMKFPYDYRD-------ERMMSHVK------------H-I 276
                  |..|:.:...::.|:|..|..::..|:..       ::::::|:            | :
Human   180 LPYSDEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLL 244

  Fly   277 VARCSNSHLEAAVSQTLSAL--LKRLTDLERHEADLRACQTNDKSGPE---------------TP 324
            :|:..:|....|..:.||.:  ||...:||......||........||               .|
Human   245 LAQLEHSEPIEAEPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAP 309

  Fly   325 LNCPTATQYAQIVCRVEKKLAKHI----GGEEFLQCSSMILLDK--------QKKWDQPSTSGAP 377
            ...|...|..:....:|...|..:    ..|:....|..:.|:.        |..|  ||...|.
Human   310 APAPELQQAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSW--PSPVVAE 372

  Fly   378 PGAQD---------PKKTCNLETYLD----------------WSAR-----------LRL----- 401
            .|..:         |.......|.:|                ||.|           :|.
Human   373 NGLSEEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQF 437

  Fly   402 -FVCNEIL------QSVGIEGRSRTVELWSGVAQYCLLVGNYNSATAILESLESPAIARLKITWS 459
             .|.|.::      :|.....|:|.||.|..||:.|.::.|::|..|||.:|:|.:|.|||.||.
Human   438 NSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWE 502

  Fly   460 KLQVTCQQLDCMQRHAEGHGHLWQKQAISLNEQ---QEGLK-------TDKQAPKEP----AAQG 510
              .|:.......|:.:|...   .:...||:.:   :||..       ..|:|.|.|    ..||
Human   503 --DVSRDSFRIFQKLSEIFS---DENNYSLSRELLIKEGTSKFATLEMNPKRAQKRPKETGIIQG 562

  Fly   511 AAPTQGAVAIAITTSSDSDEKPSTSGRVAG----------IAGISAATMESAPVPVASGSNVDAA 565
            ..|..|.. :......|:..|....||:..          ||.|...........:|......|.
Human   563 TVPYLGTF-LTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQFGAW 626

  Fly   566 TAAAARTSTTAATTPLASSGKPNDWVVIPVFADIVKLALGERENCLQRLANGHINMAAFDRMAAI 630
            ..|..|.|.|.:.........|::                ...|.|:...|..|.....||.|..
Human   627 FRAVERLSETESYNLSCELEPPSE----------------SASNTLRTKKNTAIVKRWSDRQAPS 675

  Fly   631 V------GAFTKHMQAMKAAQAPSSGEYEHFCRHMQQTTKLGEAELMMASFDCEEPNNAEKLMYD 689
            .      .:.:|....::.....|||:...........:...:.|.:..||..|.|:..||..::
Human   676 TELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWE 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	28/149 (19%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	43/198 (22%)
RALGDS	NP_006257.1	RasGEFN	112..248	CDD:214571	23/132 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..365		13/84 (15%)
		RasGEF	382..644	CDD:238087	59/267 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	666..689		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..776		4/12 (33%)
		RalGDS_RA	798..883	CDD:176351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910