DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and rasgrf1

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_009291904.1	Gene:	rasgrf1 / 568885	ZFINID:	ZDB-GENE-090311-28	Length:	1263	Species:	Danio rerio

Alignment Length:	388	Identity:	79/388 - (20%)
Similarity:	130/388 - (33%)	Gaps:	120/388 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 NEDLVQYD----------VPKNPHKRSQCDINFESSVLGSGGIMYINGRIVSG--PLD------- 197
            :.|.:|.|          .|..| |..:|..:.|.|:..     |.||.::|.  .||
Zfish   833 DNDQIQSDEAEAEVSPTKSPTTP-KNVKCKNSSEFSLFS-----YNNGMVMSSCRELDNNRSALS 891

  Fly   198 -------------------------SLIETLLPKDVVDLDKEFVFSFLLSCRLFLRPHELLGRLL 237
                                     ||..|..|.|..:.|||||.....:.|
Zfish   892 AASAFAIATAGANEGTPTKEKYRRMSLASTGFPTDQRNGDKEFVIRRAATNR------------- 943

  Fly   238 DSVPESECLESLVSLLAEWTMKFPYDYRDE-----RMMSHVKHIVARCSNSHLEAAVSQTLSA-- 295
                       ::::|..|..|...|:...     :::|.::.::      |....::|...|
Zfish   944 -----------VLNVLRHWVSKHSQDFETNTELKMKVISFLEEVM------HDPELLTQERKAAA 991

  Fly   296 -LLKRLTDLERHEADLRACQTN----DKSGPETPLNCPTATQYAQIVCRVEKKLAKHIGGEEFLQ 355
             :::.||  :....|.:.|...    .:.|........:|.:.|:.:..::..:.|.|..|||..
Zfish   992 NIIRTLT--QEDPGDNQICLEEVLQMAEGGKSESFENHSALEIAEQLTLLDHLVFKVIPYEEFFG 1054

  Fly   356 CSSMILLDKQKKWDQPSTSGAPPGAQDP---KKTCNLETYLDWSARLRLFVCNEILQSVGIEGRS 417
             ...:..||.:|              .|   |.|.:.....|       .:..|||:...:..|.
Zfish  1055 -QGWMKNDKNEK--------------TPYIMKTTKHFNDISD-------LIATEILRCEDVNVRV 1097

  Fly   418 RTVELWSGVAQYCLLVGNYNSATAILESLESPAIARLKITWSKL-QVTCQQLDCMQRHAEGHG 479
            ..:|.|..||..|..:.|||:...|..||...:|.|||.||.|: :.|...:|.:|:.....|
Zfish  1098 AVMEKWVAVADICRCLHNYNAVLEITSSLNRSSIFRLKKTWLKVSKQTKTVIDKLQKLVSSEG 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	21/143 (15%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	37/142 (26%)
rasgrf1	XP_009291904.1	PH_RasGRF1_2	19..154	CDD:270081
		PH	24..129	CDD:278594
		RhoGEF	244..425	CDD:214619
		PH-like	474..596	CDD:302622
		PH	489..592	CDD:278594
		RasGEF_N	643..>691	CDD:279012
		REM	<928..997	CDD:295342	14/98 (14%)
		RasGEF	1024..1261	CDD:214539	40/159 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910