DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and rapgef4a

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_021334493.1	Gene:	rapgef4a / 559170	ZFINID:	ZDB-GENE-070912-385	Length:	1025	Species:	Danio rerio

Alignment Length:	434	Identity:	85/434 - (19%)
Similarity:	153/434 - (35%)	Gaps:	136/434 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 TISVGPKNEDLVQYDVPKNPHKRSQCDINFESSVLGSGGIMYINGRIVSGPLDSLIETLLPKDVV 209
            |:.:....||::   |.:..:.||.          .|..:.|   .::||..:.::|.||  :.:
Zfish   484 TVRLKEHEEDVL---VLEKANNRSS----------SSSPLKY---TVMSGTPEKILEHLL--ETM 530

  Fly   210 DLDKEFVFS------FLLSCRLFLRPHELLGRLL--------DSVPESECLE-------SLVSLL 253
            .||.:|..|      |||...:|: |:..|..||        ....|.|.::       .:|.|:
Zfish   531 KLDCQFSESDPALDDFLLMHCVFV-PNSQLCPLLMTHYHAQASQGSEQERMDYTLNNKRRVVRLV 594

  Fly   254 AEW-TMKFPYDYRDERMMSHVKHIVAR-CSNSHLEAAVSQ---TLSALLKRLTD-----LERHEA 308
            .:| ::...:...::...|.::..... |.:|.|..|:..   .|..::|:.:|     .::|:.
Zfish   595 LQWASINTDHLQEEDSSFSFIQEFYEMVCEDSRLTPALKDHLPELEKIIKQNSDDGRPSQKKHKV 659

  Fly   309 DLRACQT-NDKSGPETPLN----------C----------PTATQYAQIVCRVEKKLAK------ 346
            .||...| ||:.....|:.          |          |.:....:::..|..||:.
Zfish   660 LLRQFSTGNDRLQKRQPIKSTDEILFKVYCSDHTYSTIRVPVSASVREVIAAVSDKLSSGDDLLL 724

  Fly   347 -HI---GGEEFLQCSSMILLDKQK--------KWDQ-------PSTSGAPPGAQD---------- 382
             |:   |.:|.|:.|.:.:.....        ..||       |...|...|:..
Zfish   725 IHLNSAGDKELLKPSDVSIFSSLSINGRLFVCPRDQIDSLTPLPEQEGPSAGSMSTFELMSSKDL 789

  Fly   383 ------------------------------PKKTCNLETYLDWSARLRLFVCNEILQSVGIEGRS 417
                                          .|.|.||:.:|.....::|:|..|:.....:..|.
Zfish   790 AHQMTLYDWELFHCVHEHELIYHTFGRHHFKKTTANLDLFLRRFNEVQLWVVTEVCLCPALSKRV 854

  Fly   418 RTVELWSGVAQYCLLVGNYNSATAILESLESPAIARLKITWSKL 461
            :.::.:..:|.:|....|.||..||:..|.:||:.||..||.||
Zfish   855 QLLKKFIKIAAHCKEFKNLNSFFAIIMGLGNPAVCRLSQTWEKL 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	27/129 (21%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	38/193 (20%)
rapgef4a	XP_021334493.1	CAP_ED	49..158	CDD:237999
		DEP_Epac	226..354	CDD:239884
		CAP_ED	376..487	CDD:237999	1/2 (50%)
		RasGEF_N	513..618	CDD:306971	23/107 (21%)
		RasGEF	781..1023	CDD:214539	25/118 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910