DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34393 and rasgef1b

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_031756070.1	Gene:	rasgef1b / 549667	XenbaseID:	XB-GENE-1015760	Length:	588	Species:	Xenopus tropicalis

Alignment Length:	575	Identity:	143/575 - (24%)
Similarity:	228/575 - (39%)	Gaps:	149/575 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 PKNEDLVQYD-----VPKNPHKRSQCDIN------FESSVLGSGGIMYINGRIVSGPLDSLIETL 203
            |..:.|  ||     :|:.|...:..|.:      ::|.......:.|.:..::||.|::||:.|
Frog   103 PSEKSL--YDPVLERMPQTPTLVAMFDSSSFHRNLYQSKEESCSELYYQDNNLLSGSLEALIQHL 165

  Fly   204 LPKDVVDL--DKEFVFSFLLSCRLFLRPHELLGRL--------------LDSVPESECLESLVSL 252
            :|.  ||.  |:.::|:||||.|||:.|.||:.|:              ||.....:....::.|
Frog   166 VPN--VDYYPDRTYIFTFLLSSRLFIHPSELMARVCHVCMEQQRLNEPGLDKSQVRKIAPKILQL 228

  Fly   253 LAEWTMKFPYDYRDERMMSHVKHIVARCSNSH--LEAAVSQTLSALLKRLTDLERHEADLRA--C 313
            |.|||..||||:||||||.::|....|.:|..  ....|.|.:..|:::|..|.::|..:..  .
Frog   229 LTEWTETFPYDFRDERMMRNLKDTAHRITNGDEMYRKNVQQIIQNLIRKLASLTQYEELITKINA 293

  Fly   314 QTND-----KSGPETPLN-----CPTATQYAQIVCRVEKKLAKHIGGEEFLQCSSMILLDKQKKW 368
            |:.|     |:.|::...     |......||.:..:|.:...:||.|||:|  :.:..|.....
Frog   294 QSTDRMTVLKTKPQSIQRDIITVCSDPYTVAQQLTHIELERLSYIGPEEFVQ--AFVQKDPLDNN 356

  Fly   369 DQPSTSGAPPGAQDPKKTCNLETYLDWSARLRLFVCNEILQSVGIEGRSRTVELWSGVAQYCLLV 433
            :|...|       |.||..|||.|::|..||...|..||...|..:.|:|.:|.:..||:.|..:
Frog   357 EQNCYS-------DRKKPRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEFFIDVARECFNI 414

  Fly   434 GNYNSATAILESLESPAIARLKITWSKLQVTCQQLDCMQRHAEGHGHLWQKQAISLNEQQEGLKT 498
            ||:||..||:..:....::|||.||:|::..  :.|.::...:
Frog   415 GNFNSLMAIISGMNMSPVSRLKKTWAKVKTA--KFDILEHQMD---------------------- 455

  Fly   499 DKQAPKEPAAQGAAPTQGAVAIAITTSSDSDEKPSTSGRVAGIAGISAATMESAPVPVASGSNVD 563
                                                                    |.::..|..
Frog   456 --------------------------------------------------------PSSNFYNYR 464

  Fly   564 AATAAAARTSTTAATTPLASSGKPNDWVVIPVFADIVKLALGERENCLQRLANGHINMAAFDRMA 628
            .|...||:.|.||.:.        .:.:|||..:.::|......|.|..||.|||:|...|..:|
Frog   465 TALRGAAQRSLTAHSN--------REKIVIPFCSLLIKDIYFLNEGCTSRLPNGHVNFEKFWELA 521

  Fly   629 AIVGAFTKHMQAMKAAQAPSSGEYEHFCRHMQQTTKL-GEAELMMASFDCEEPNN 682
            ..|..|    ...|..:.|.  |.:....|...|..: .|..|.:||::.|.|.|
Frog   522 KQVSEF----MTWKQVECPF--EKDRKILHYVLTAPIFSEDALYLASYESEGPEN 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	43/121 (36%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	45/138 (33%)
rasgef1b	XP_031756070.1	REM	157..281	CDD:100121	44/125 (35%)
rasgef1b	XP_031756070.1	RasGEF	323..518	CDD:395492	65/291 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020