DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34393 and Rgl

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	575	Identity:	102/575 - (17%)
Similarity:	175/575 - (30%)	Gaps:	216/575 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QKSRGQRDRDKCHHGHHQHHRRHHRRRCRISSNSSSTDSESADECGLELGESGADSREAGAGGGA 89
            |:.:.|:.:|......|.||....|:|     ..|.|..|....|..........||.|.|
  Fly    73 QRQQQQQQQDAKDSKRHYHHHTCPRQR-----KKSMTPVEPTHLCQKHQEAKQRRSRSASA---- 128

  Fly    90 GLQVAQGGIFSLDPGHLTAETALLGGNIRYRRRHSAEQLSAYDLEMGFQQLE------------- 141
                                        :.||..|.......|:.......|
  Fly   129 ----------------------------KPRRNSSYHSYDDLDVSSAVLNAERKVVASLKYLCAC 165

  Fly   142 LGTTI-SVGPKNEDL-------------------------------VQYDVPKNPHKRSQCD--- 171
            .|.|: ::..|.:||                               |:|..| .|...:..|
  Fly   166 TGATLRNLSKKTKDLHAKNYTYTKPTWRLWGEEHEKNAIFTVYLKKVRYHRP-TPTASNDSDDEI 229

  Fly   172 --INFESSVLGSGGIMYINGRIV-SGPLDSLIETLLPKDVVDLDKEFVFSFLLSCRLFLRPHELL 233
              :.:|:          :..|.| :..|..|:|.|...| .:|:..|:..||.:.|.|..|.::|
  Fly   230 SHLEWET----------VRVRFVKAATLARLVEALATDD-GELESTFINVFLSTYRTFSTPKQVL 283

  Fly   234 ------------------------GRLLD-------SVPESECLESLVSLLAEWTMKFPYDYRDE 267
                                    |:::|       |:.|.. .::|||.|..|...||.|:.::
  Fly   284 SLLTQRYDALHEKHLEELEQAQQNGQVMDPAYDPHASIHEQH-KKTLVSALHVWLDGFPEDWHED 347

  Fly   268 RMMSHVKHIVARCSNSHLEAAVSQTLSALLKRL----------TDLERHE--ADLRACQ------ 314
            .:...:.....|...|.|...|...|..|:|:.          ::...|.  :..|:.|
  Fly   348 NLQQILAFATKRLKRSDLHIKVLNRLERLIKQSLYGNGGGSGGSENNGHSWLSAARSQQMQQFMI 412

  Fly   315 ----------TNDKSG------------------------PETPLNCPTATQYAQIVCRVE---- 341
                      |:..:|                        |..|:.     .:|:.:.|::
  Fly   413 PTHYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVR-----HFAEQLTRMDTELF 472

  Fly   342 KKLAKHIGGEEFLQCSSMILLDKQKKWDQPSTSGAPPGAQDPKKTCNLETYLDWSARLRLFVCNE 406
            |:|..|       ||..       ..|.:..:.|:        :|. :.|...::|.|...|.:.
  Fly   473 KRLIPH-------QCLG-------HTWARRDSGGS--------ETV-VATINQFNAVLFRVVSSI 514

  Fly   407 ILQSVGIEGRSRTVELWSGVAQYCLLVGNYNSATAILESLESPAIARLKITWSKL 461
            ::..:..:.|:..:..|..:||...::.|::|..||:.:|.|.:|.||...|..|
  Fly   515 LIDRLKPQERALNISRWIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	32/134 (24%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	29/132 (22%)
Rgl	NP_001261814.1	REM	246..378	CDD:100121	31/133 (23%)
		RasGEF	454..719	CDD:214539	30/144 (21%)
		RalGDS_RA	858..946	CDD:176351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010