Protein Alignment CG34393 and Rasgef1b

DIOPT Version :10

• Sequence 1: NP_608753.2
• Gene: CG34393 / 33534
• FlyBaseID: FBgn0085422
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_665838.1
• Gene: Rasgef1b / 320292
• MGIID: 2443755
• Length: 473
• Species: Mus musculus
• Alignment Length: 565
• Identity: 141/565 - (24%)
• Similarity: 233/565 - (41%)
• Gaps: 145/565 - (25%)

  Fly   160 VPKNPHKRSQCDIN------FESSVLGSGGIMYINGRIVSGPLDSLIETLLPKDVVDL--DKEFV 216
            :|:.|...:..|.:      ::|:....||:.|.:..::||.|::||:.|:|.  ||.  |:.::
Mouse     1 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPN--VDYYPDRTYI 63

  Fly   217 FSFLLSCRLFLRPHELLGRLLDSVPESECLE--------------SLVSLLAEWTMKFPYDYRDE 267
            |:||||.|||:.|:||:.::.....|.:.|.              .::.||.|||..||||:|||
Mouse    64 FTFLLSSRLFMHPYELMAKVCHLCVEHQRLSEGDGDKNQMRKIAPKILQLLTEWTETFPYDFRDE 128

  Fly   268 RMMSHVKHIVARCSNSHLEA---AVSQTLSALLKRLTDLERHE---ADLRACQTND----KSGPE 322
            |||.::|.:..|.::...:.   .|.|.:..|:::|..|.::|   |.|.:..|:.    |:.|:
Mouse   129 RMMRNLKDLAHRMASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKLSSTATDRLTVLKTKPQ 193

  Fly   323 TPLN-----CPTATQYAQIVCRVEKKLAKHIGGEEFLQC-SSMILLDKQKKWDQPSTSGAPPGAQ 381
            :...     |......||.:..:|.:...:||.|||:|. .....||..|..           ..
Mouse   194 SIQRDIMTVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKSC-----------YS 247

  Fly   382 DPKKTCNLETYLDWSARLRLFVCNEILQSVGIEGRSRTVELWSGVAQYCLLVGNYNSATAILESL 446
            :.|||.|||.|::|..||...|..||...|..:.|:|.:|.:..||:.|..:||:||..||:..:
Mouse   248 ERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGM 312

  Fly   447 ESPAIARLKITWSKLQVTCQQLDCMQRHAEGHGHLWQKQAISLNEQQEGLKTDKQAPKEPAAQGA 511
            ....::|||.||:|::..  :.|.::...:
Mouse   313 NMSPVSRLKKTWAKVKTA--KFDILEHQMD----------------------------------- 340

  Fly   512 APTQGAVAIAITTSSDSDEKPSTSGRVAGIAGISAATMESAPVPVASGSNVDAATAAAARTSTTA 576
                                                       |.::..|...|...||:.|.||
Mouse   341 -------------------------------------------PSSNFYNYRTALRGAAQRSLTA 362

  Fly   577 ATTPLASSGKPNDWVVIPVFADIVKLALGERENCLQRLANGHINMAAFDRMAAIVGAFTKHMQAM 641
            .::        .:.:|||.|:.::|......|.|:.||.|||:|...|..:|..|..|    ...
Mouse   363 HSS--------REKIVIPFFSLLIKDIYFLNEGCVNRLPNGHVNFEKFWELAKQVSEF----MTW 415

  Fly   642 KAAQAPSSGEYEHFCRHMQQTTKLGEAELMMASFDCEEP-NNAEK 685
            |..:.|...: ....:::.......|..|.:||::.|.| ||.||
Mouse   416 KQVECPFERD-RKVLQYLLSVPVFSEDALYLASYESEGPENNIEK 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_608753.2	REM	196..300	CDD:100121	41/122 (34%)
		RasGEF	334..>473	CDD:459872	45/139 (32%)
Rasgef1b	NP_665838.1	REM	42..167	CDD:100121	42/126 (33%)
		RasGEF	209..403	CDD:459872	66/292 (23%)