DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34393 and Ralgds

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_006233812.1	Gene:	Ralgds / 29622	RGDID:	3533	Length:	907	Species:	Rattus norvegicus

Alignment Length:	704	Identity:	134/704 - (19%)
Similarity:	217/704 - (30%)	Gaps:	233/704 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 LDPG--HLTAETALLGGNIRYRRRHSAEQL---SAYDLEMGFQQLELGTTIS---VGPKNEDLVQ 157
            |||.  .|.:.|..:|           |:|   ..|.:.:...||..|.|..   :|.:||..:.
  Rat    53 LDPDLPRLESSTQEIG-----------EELINGVIYSISLRKVQLHPGATKGQRWLGCENESALN 106

  Fly   158 -YDVPKNPHKRSQCDINFESSVLGSGGIMYINGRIVSGPLDSLIETLLPKDVVDLDKEFVFSFLL 221
             |:.         |.:.                .:.:|.|:.|:|.|:|. ....|..:|..||.
  Rat   107 LYET---------CKVR----------------TVKAGTLEKLVEHLVPA-FQGSDLSYVTVFLC 145

  Fly   222 SCRLFLRPHELLGRLL------------------------DSVPESECLESLVSLLAEWTMKFPY 262
            :.|.|....::|..|.                        |..|:.:...::.|:|..|..::..
  Rat   146 TYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSE 210

  Fly   263 DYRDERMMSHVKHIVARCSNSHLEAAVSQTLSALLKRLTDLERHEADLRACQ------------- 314
            |:........:|.:||....:...:.:.:....||.:|.|||..|.:..|..
  Rat   211 DFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEVEPEALSPAPVLSLKPASQL 275

  Fly   315 --------TNDKSGPETPLNCP------TATQYAQIVCRVEKKLAKHIGGEEFL--------QCS 357
                    |..::...||:..|      .::........:|..|...:..|..|        ..|
  Rat   276 EPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTVS 340

  Fly   358 SMILLDK--------QKKWDQPSTSG----APPGAQ--DPKKTCNLETYLD-------------- 394
            ..:.|:.        :..|..|.|:.    |.|...  .|.......|.:|
  Rat   341 QSLHLEPAPVPAPALEPSWPLPETTENGLCAKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLG 405

  Fly   395 --WSAR-----------LRLFVC--NEIL----------QSVGIEGRSRTVELWSGVAQYCLLVG 434
              ||.|           :|..|.  |.:.          ||:....|:|.||.|..||:.|.::.
  Rat   406 SIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKASDRARVVEHWIEVARECRVLK 470

  Fly   435 NYNSATAILESLESPAIARLKITWSKLQVTCQQLDCMQRHAEGHGHLWQKQAISLNEQQEGLKTD 499
            |::|..|||.:|:|.||.|||.||.::             :.|...::||.:...:::..
  Rat   471 NFSSLYAILSALQSNAIHRLKKTWEEV-------------SRGSFRVFQKLSEIFSDENN----- 517

  Fly   500 KQAPKEPAAQGAAPTQGAVAIAITTSSDSDEKPSTSGRVAGIAGISAATMESAPVPVASGSNVDA 564
                                  .:.|.:...|..||         ..||:|..|         ..
  Rat   518 ----------------------YSLSRELLIKEGTS---------KFATLEMNP---------RR 542

  Fly   565 ATAAAARTSTTAATTPLASSGKPNDWVVIPVFADIVKLALGERENCLQRLANGHINMAAFDRMAA 629
            .......|.....|.|...:          ...|:|.|....::....||.|.......|:.:|.
  Rat   543 TQRRQKETGVIQGTVPYLGT----------FLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQ 597

  Fly   630 IVGAFTKHMQAMKAAQAPSSGEYEHFCRHMQQTTKLGEAELMMASFDCEEPNNA 683
            |     |.:|:  |....|....|||....:...:|.|||....|.:.|.|:.:
  Rat   598 I-----KLLQS--ACNNYSIVPEEHFGAWFRAMGRLSEAESYNLSCELEPPSES 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	24/127 (19%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	44/199 (22%)
Ralgds	XP_006233812.1	RasGEFN	112..248	CDD:214571	25/152 (16%)
		DUF3275	205..344	CDD:288521	21/138 (15%)
		RasGEF	375..637	CDD:238087	68/336 (20%)
		RalGDS_RA	791..876	CDD:176351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910