DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and RGL4

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001316353.1	Gene:	RGL4 / 266747	HGNCID:	31911	Length:	580	Species:	Homo sapiens

Alignment Length:	184	Identity:	44/184 - (23%)
Similarity:	71/184 - (38%)	Gaps:	49/184 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 CQTNDKSGPETPLNCPTATQY-----AQIVCRVEKKLAKHIGGEEFLQCSSMILLDKQKKWDQPS 372
            |:.:.|:.|...|  |..|.:     |:.:..::.:|.|.:...|.|.|.          |.|..
Human   200 CRGSVKNQPSEEL--PDMTTFPPRLLAEQLTLMDAELFKKVVLHECLGCI----------WGQGH 252

  Fly   373 TSGAPPGAQDPKKT---------CNLETYL-DWSARLRLFVCNEILQSVGIEGRSRTVELWSGVA 427
            ..|....|...:.|         |...:.| |.|.|.|              .|:|.||.|..||
Human   253 LKGNEHMAPTVRATIAHFNRLTNCITTSCLGDHSMRAR--------------DRARVVEHWIKVA 303

  Fly   428 QYCLLVGNYNSATAILESLESPAIARLKITWS--------KLQVTCQQLDCMQR 473
            :.||.:.|::|...|:.:|.|..|.:|..||:        :|:..|::...::|
Human   304 RECLSLNNFSSVHVIVSALCSNPIGQLHKTWAGVSSKSMKELKELCKKDTAVKR 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	37/156 (24%)
RGL4	NP_001316353.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..215		5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910