DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34393 and Rapgef4

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001094112.1	Gene:	Rapgef4 / 252857	RGDID:	621886	Length:	1011	Species:	Rattus norvegicus

Alignment Length:	326	Identity:	66/326 - (20%)
Similarity:	109/326 - (33%)	Gaps:	107/326 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 RLFLRPHELLGRLL--DSVPESECLESLVSLLAEWTMKFPYDYRDERMMSHVKHIVARCSNSHLE 286
            ||.|:...:.|.||  |.|..:...|..||:           ..|.|||...|..:|     .||
  Rat   579 RLVLQWAAMYGDLLQEDDVAMAFLEEFYVSV-----------SDDARMMVAFKEQLA-----ELE 627

  Fly   287 AAVSQTLSALLKRLTDLERHEADLRACQTNDKSGPE---------------------TPLNCPTA 330
            ..|.| :|...|  ...::|:..|:...|.|:...:                     |.:..|.|
  Rat   628 KTVKQ-ISEDAK--APQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVA 689

  Fly   331 TQYAQIVCRVEKKLAK---------HIGGEEF------------LQCSSMILLDKQKKWDQ---- 370
            ....:::..|..||..         :.|||:.            |..:..:....::::|.
  Rat   690 ASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKPNDVSVFTTLTINGRLFACPREQFDSLTPL 754

  Fly   371 PSTSGAPPG---------AQD-------------------------------PKKTCNLETYLDW 395
            |...|...|         ::|                               .|.|.||:.:|..
  Rat   755 PEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRR 819

  Fly   396 SARLRLFVCNEILQSVGIEGRSRTVELWSGVAQYCLLVGNYNSATAILESLESPAIARLKITWSK 460
            ...::.:|..||.....:..|.:.::.:..:|.:|....|.||..||:..|.:.|::||.:||.|
  Rat   820 FNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEK 884

  Fly   461 L 461
            |
  Rat   885 L 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	23/77 (30%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	36/193 (19%)
Rapgef4	NP_001094112.1	CAP_ED	43..158	CDD:237999
		DEP_Epac	206..334	CDD:239884
		CAP_ED	356..467	CDD:237999
		RasGEF_N	499..605	CDD:366199	8/25 (32%)
		RasGEF	768..1009	CDD:214539	25/118 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910