DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and Rasgrf2

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_036013814.1	Gene:	Rasgrf2 / 19418	MGIID:	109137	Length:	1190	Species:	Mus musculus

Alignment Length:	289	Identity:	65/289 - (22%)
Similarity:	104/289 - (35%)	Gaps:	80/289 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 DKEFVFSFLLSCRLFLRPHELLGRLLDSVPESECLESLVSLLAEWTMKFPYDYRDERMMSHVKHI 276
            ||||:.....:.|                        ::::|..|..|...|:.
Mouse   858 DKEFIIRRTATNR------------------------VLNVLRHWVSKHAQDFE----------- 887

  Fly   277 VARCSNSHLEAAVSQTLSALLKRLTDLERHEAD-----LRACQTNDKSGPETPL-------NCP- 328
                .|:.|:..|...|..:| |..||...|..     |||...:|:......|       :||
Mouse   888 ----LNNELKMNVLNLLEEVL-RDPDLLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPK 947

  Fly   329 -------TATQYAQIVCRVEKKLAKHIGGEEFLQCSSMILLDKQKKWDQPSTSGAPPGAQDPKKT 386
                   :|.:.|:.:..::..:.:.|..||||. ...:.|||.::     |......:|...:.
Mouse   948 AECFETLSAMELAEQITLLDHIVFRSIPYEEFLG-QGWMKLDKNER-----TPYIMKTSQHFNEM 1006

  Fly   387 CNLETYLDWSARLRLFVCNEILQSVGIEGRSRTVELWSGVAQYCLLVGNYNSATAILESLESPAI 451
            .||             |.::|:....|..|:..:|.|..||..|..:.|||....|..:|...||
Mouse  1007 SNL-------------VASQIMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAI 1058

  Fly   452 ARLKITWSKL-QVTCQQLDCMQRHAEGHG 479
            .|||.||:|: :.|...:|.:|:.....|
Mouse  1059 YRLKKTWAKVSKQTKALMDKLQKTVSSEG 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	14/87 (16%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	37/139 (27%)
Rasgrf2	XP_036013814.1	PH_RasGRF1_2	19..158	CDD:270081
		RhoGEF	247..428	CDD:214619
		PH	480..588	CDD:214574
		RasGEF_N	638..>686	CDD:395493
		REM	<853..925	CDD:413353	21/106 (20%)
		RasGEF	951..1187	CDD:214539	40/156 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910