DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and Rasgrf1

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_035375.1	Gene:	Rasgrf1 / 19417	MGIID:	99694	Length:	1262	Species:	Mus musculus

Alignment Length:	462	Identity:	102/462 - (22%)
Similarity:	161/462 - (34%)	Gaps:	124/462 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 GGAGLQVAQGGIFS-----------------LDPGHLTAETAL---------------LGGNIRY 119
            ||..|::|..|..|                 ||.|.|...::|               ..|.:..
Mouse   753 GGKALELASLGCSSDSYANIHSPISPFGKTTLDTGKLCMASSLPKTPEEIDVPATIPEKPGELSA 817

  Fly   120 RRRHSAEQLSAYDLEMGFQQLELGTTIS-----VGPK---NEDLVQYDVP----KNPHKRSQC-D 171
            .|:||::.|.....:......|..|.:|     ..||   |..:.::  |    .|....:.| |
Mouse   818 SRKHSSDVLKEESEDDQNHSDEDNTEVSPVKSPPTPKSFLNRTITEF--PFFNYNNGILMTTCRD 880

  Fly   172 I--NFESSVLGSGGIMYINGRIVSGPLD-------SLIETLLPKDVVDLDKEFVFSFLLSCRLFL 227
            :  |..|::..:............||.:       ||..|....|..::|||||.....:.|
Mouse   881 LVDNNRSTLSATSAFAIATAGANEGPSNKEVFRRMSLANTGFSSDQRNIDKEFVIRRAATNR--- 942

  Fly   228 RPHELLGRLLDSVPESECLESLVSLLAEWTMKFPYD--------YRDERMMSHVKHIVARCSNSH 284
                                 ::::|..|..|...|        ||....:..|.|.....:...
Mouse   943 ---------------------VLNVLRHWVTKHTQDFDTDDTLKYRVICFLEEVMHDPDLLTQER 986

  Fly   285 LEAA-VSQTLSALLKRLTDLERH----EADLRACQTNDKSGPET-PLNCPTATQYAQIVCRVEKK 343
            ..|| :.:||:  |:..|  |:|    |..|..      .|.:| |.....|.:.|:.:..::..
Mouse   987 KAAANIIRTLT--LEETT--EQHSMLEEVILMT------EGVKTEPFENHPALEIAEQLTLLDHL 1041

  Fly   344 LAKHIGGEEFLQCSSMILLDKQKKWDQPSTSGAPPGAQDPKKTCNLETYLDWSARLRLFVCNEIL 408
            :.|.|..|||.....|    |.:|:::      .|......|..|         .:..|:.:||:
Mouse  1042 VFKSIPYEEFFGQGWM----KAEKYER------TPYIMKTTKHFN---------HVSNFIASEII 1087

  Fly   409 QSVGIEGRSRTVELWSGVAQYCLLVGNYNSATAILESLESPAIARLKITWSKL-QVTCQQLDCMQ 472
            ::..|..|:..:|.|..||..|..:.|||:...|..|:...||.|||.||.|: :.|...||.:|
Mouse  1088 RNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLKVSKQTKSLLDKLQ 1152

  Fly   473 RHAEGHG 479
            :.....|
Mouse  1153 KLVSSDG 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	23/119 (19%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	38/139 (27%)
Rasgrf1	NP_035375.1	PH-like	19..155	CDD:302622
		PH	24..130	CDD:278594
		RhoGEF	248..429	CDD:214619
		PH-like	435..586	CDD:302622
		PH	482..587	CDD:278594
		RasGEF_N	638..>687	CDD:279012
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	714..738
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	800..854		8/53 (15%)
		REM	<927..996	CDD:295342	16/92 (17%)
		RasGEF	1023..1259	CDD:214539	41/156 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910