DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and Rapgef6

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_006532623.1	Gene:	Rapgef6 / 192786	MGIID:	2384761	Length:	1614	Species:	Mus musculus

Alignment Length:	518	Identity:	115/518 - (22%)
Similarity:	180/518 - (34%)	Gaps:	129/518 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IACGTRCK--QTVLQKSRGQRDRDKCHHGHHQHHRRHHRRRCRISSNSSSTDSESADECGLELGE 75
            |||..:.|  |.||||:..:.....|..|                      .||......:|..|
Mouse   520 IACAAKAKWRQVVLQKASRESPLHFCLTG----------------------GSEKGFGVFVEEVE 562

  Fly    76 SGADSREAGAGGGAGLQVAQGGIFSLDPGHLTAETALLGGNIRYRRRHSA-----------EQLS 129
            ||:.:.:||...|..:....|..|.    ::|...||   .|.....|.|           |.||
Mouse   563 SGSKAADAGLKRGDQVMEVNGQNFE----NITLAKAL---EILRNNTHLALTVKTNIFVFKELLS 620

  Fly   130 AYDLE-MGFQQLELGTTISVGPKNEDLVQYDVPKNPHKRSQCDINFESSVLGSGGIMYINGRIVS 193
            ..:.| .|...:   ..|:....|...:| |||.:..:..|           ..|...|....||
Mouse   621 RTEQEKSGVPHI---PKIAEKKSNRHSIQ-DVPGDMEQAPQ-----------EKGNKKIKANTVS 670

  Fly   194 GP-------LDSLIETLLPKDVV-------DLDKEFVFSFLLSCRLFLRPHELLGRLLDSVPESE 244
            |.       ||....::||..:.       ..|...|.:  ..||..|....:.|.|..|.|  :
Mouse   671 GGRNKIRKILDKTRFSILPPKLFSDGGLSQSQDDSIVGT--RHCRHSLAIMPIPGTLSSSSP--D 731

  Fly   245 CLESLVSLL---AEWTMKFPY-------DYRDERMMSHV--------KHIVAR---------CSN 282
            .|:...|:|   ....:.|.|       .::.::...::        |.:|.:         .|:
Mouse   732 LLQPTTSMLDFSNPSAVGFYYIPDQVIRVFKADQQSCYIIISKDTTAKEVVCQAVQEFGLTGASD 796

  Fly   283 SHLEAAVSQTLSALLK--RLTDLERHEADLRACQTND----KSGPETPLNCPTATQYAQIVCRVE 341
            ::....||.|...::|  ||.|.....||  ..|.|.    |:..||...|  :.:.||.:.: |
Mouse   797 TYSLCEVSVTPEGVIKQRRLPDQFSKLAD--RIQLNGRYYLKNNMETETLC--SDEDAQELLK-E 856

  Fly   342 KKLAKHIGGEEFLQCSSMILLDKQKKWDQPSTSGAPPGA------QDPKKTCN--LETYLDWSAR 398
            .:|:       .||.|::.:..:....|........|..      :...||.|  |:.:.|...:
Mouse   857 SQLS-------MLQLSTIEVATQLSMRDFDLFRNIEPTEYIDDLFKLDSKTGNTHLKQFEDIVNQ 914

  Fly   399 LRLFVCNEILQSVGIEGRSRTVELWSGVAQYCLLVGNYNSATAILESLESPAIARLKITWSKL 461
            ...:|.:|||.......|.:.::.:..:|.:|....|:||..||:..|....:|||:.||.||
Mouse   915 ETFWVASEILSESNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRGTWEKL 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	25/139 (18%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	34/136 (25%)
Rapgef6	XP_006532623.1	CAP_ED	37..>82	CDD:381773
		CAP_ED	280..380	CDD:237999
		RasGEFN	412..525	CDD:214571	3/4 (75%)
		PDZ_signaling	529..609	CDD:238492	24/108 (22%)
		RA_PDZ-GEF1	756..838	CDD:340483	15/83 (18%)
		RasGEF	862..1086	CDD:238087	30/116 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910