DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and plc-1

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001360638.1	Gene:	plc-1 / 181274	WormBaseID:	WBGene00004036	Length:	3554	Species:	Caenorhabditis elegans

Alignment Length:	414	Identity:	73/414 - (17%)
Similarity:	131/414 - (31%)	Gaps:	160/414 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 QVAQGGIFSLDPGHLTAETALLGGNIRYRRRHSAEQLS--------------------------- 129
            ::..||:.:.|..:|   .|::..|:....|||...:.
Worm  1955 RIGVGGLLNADKINL---VAIVLDNLELFHRHSRTMIKLLEEQAVPPIQIPQNEREQKEKEAKTY 2016

  Fly   130 ---------------------AYDLEMGFQQLELGTTI-------------------SVGPKNED 154
                                 .:||:: .|:|:.|||:                   |.|..|..
Worm  2017 EPVQVVRGSSHGVALIPLDTLTFDLDV-IQRLQHGTTVIHYEPDSGRSNLCLLRLDPSCGQINWH 2080

  Fly   155 LVQYDVPKNPHKRSQCDINFESSVL---------------------GSGGIMYINGRIVSGPLDS 198
            .:.|.|.|:|.::   |:..:.||.                     |:||:....|.:..    |
Worm  2081 KISYSVNKDPKEK---DVLAKVSVSNLQPLDSGRGAPSPMPSGRTPGTGGVGVEEGELKL----S 2138

  Fly   199 LIETLLPKDVVDLDKEFVF--------SFLLSC--------------RLFLRPHELLGRLLDSVP 241
            :::.:...|..|:|.|.::        |..:||              ..||.|.::.....:.
Worm  2139 VVKGVELVDSYDIDIEAIYRRHSMEEMSVPVSCWKVSHGQLLSDNEFIYFLAPQQIAQFWTNG-- 2201

  Fly   242 ESECLESLVSLLAEWTMKFPYDYRDERMMSHVKHIV---------ARCSNSHLEAAVSQTLSALL 297
                |:|:|..| :...::|     :|.|..:|::.         :.|.....||..:..||
Worm  2202 ----LQSVVKSL-QGQQRYP-----DRRMLWIKNVYLSLYEITGESNCGPRPFEALQAFGLS--- 2253

  Fly   298 KRLTDLERHEADLRACQTNDKSGPETPLNCPTATQYAQIVCRVEKKL--AKHIGG-EEFLQCSSM 359
                     :.:..|.:.||.|....|..  ..::...:...::|||  |...|. .:..|..|.
Worm  2254 ---------QTNTNATRPNDSSLSSEPGG--AKSRLKNLKNAMQKKLRGASREGSRSQSPQPHSP 2307

  Fly   360 ILLDKQKKWDQPSTSGAPPGAQDP 383
            ::.....| .|.|:...|||...|
Worm  2308 LVRPPSIK-SQISSQSGPPGPNSP 2330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	24/134 (18%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	14/53 (26%)
plc-1	NP_001360638.1	Ank_2	193..328	CDD:372319
		ANK repeat	193..219	CDD:293786
		ANK repeat	221..293	CDD:293786
		ANK repeat	295..328	CDD:293786
		B41	<1421..1598	CDD:214604
		RasGEF	1748..2019	CDD:214539	9/66 (14%)
		EFh_PI-PLCepsilon	2401..2581	CDD:320033
		EF-hand motif	2402..2429	CDD:320033
		EF-hand motif	2435..2500	CDD:320033
		EF-hand motif	2509..2544	CDD:320033
		PLN02952	2526..3215	CDD:178538
		EF-hand motif	2549..2581	CDD:320033
		PI-PLCc_epsilon	2595..3059	CDD:176538
		Ubiquitin_like_fold	3255..3349	CDD:391949
		RA2_PLC-epsilon	3421..3524	CDD:340478
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910