DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and AgaP_AGAP009180

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_319944.4	Gene:	AgaP_AGAP009180 / 1280136	VectorBaseID:	AGAP009180	Length:	1552	Species:	Anopheles gambiae

Alignment Length:	393	Identity:	71/393 - (18%)
Similarity:	136/393 - (34%)	Gaps:	94/393 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 DLVQYDVPKNPHKRSQCDINFESSVLGSGGIMYINGRIVSGPLDSLIETLLPKDVVDLDKEFVFS 218
            |:.::.||..|.       |.........|:..|.|    ..|..|||.|...  :..|..||.:
Mosquito   569 DMYKFAVPDGPS-------NIVLEEREGTGVPLIKG----ATLCKLIERLTYH--IYADPMFVRT 620

  Fly   219 FLLSCRLFLRPHELLGRLL------------DSVPESECLES----------------------- 248
            ||.:.|.|..|.|||..|:            |...|.|....
Mosquito   621 FLTTYRSFCSPKELLQLLVERFDIPDPAVVYDPAAEKELAGDTDKFHKNSQREDWKRYKKEYVQP 685

  Fly   249 ----LVSLLAEWTMKFPYDY-RDERMMSHVKHIVARCSNSHLEAAVSQTLSALLKRLTDLERHEA 308
                ::::|..|.....||: ||..::..::..:.......:...|...:. :::|..:.|.:..
Mosquito   686 VQFRVLNVLRHWVDHHFYDFERDGELLESLERFLETVRGKSMRKWVDSVMK-IVQRKNESEDNHR 749

  Fly   309 DLRACQTNDKSGPE--TPLNCPT--------ATQYAQIVCRVEKKLAKHIGGEEFLQCSSMILLD 363
            .:.....:.....|  .|||...        ..:.|:.:..:|.::.|::...|.:   ..:...
Mosquito   750 QITFAFGHSPPAIEHHLPLNGENEFNLLMLHPLELARQLTLLEFEMYKNVKPSELV---GSVWTG 811

  Fly   364 KQKKWDQPSTSGAPPGAQDPKKTCNLETYLDWSARLRLFVCNEILQSVGIEGR----SRTVELWS 424
            |.|:...|                ||...:..:.....::...|:::...|.|    ||.:|:..
Mosquito   812 KDKETTSP----------------NLLKIMHHTTNFTRWIEKSIIEAENFEERVAMASRAIEVMM 860

  Fly   425 GVAQYCLLVGNYNSATAILESLESPAIARLKITWSKLQVTCQQL--DCMQRHAEGHGHLWQKQAI 487
            .:..    :.|:|...:|:.:.:..|:.|||:|...:....||:  :|.:.: ..|...:|::..
Mosquito   861 VLQD----LNNFNGVLSIVSAFQGAAVHRLKLTLEDIPKRHQQVLAECRELN-NSHFKKYQEKLR 920

  Fly   488 SLN 490
            |:|
Mosquito   921 SIN 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	27/143 (19%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	26/144 (18%)
AgaP_AGAP009180	XP_319944.4	Histone	47..178	CDD:278551
		H2A	105..180	CDD:305064
		RhoGEF	209..392	CDD:238091
		PH_SOS	435..541	CDD:269963
		PH	441..540	CDD:278594
		RasGEFN	591..741	CDD:214571	30/156 (19%)
		RasGEF	776..1013	CDD:238087	30/172 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910