DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and AgaP_AGAP007307

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_308514.4	Gene:	AgaP_AGAP007307 / 1269861	VectorBaseID:	AGAP007307	Length:	998	Species:	Anopheles gambiae

Alignment Length:	401	Identity:	73/401 - (18%)
Similarity:	132/401 - (32%)	Gaps:	139/401 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 IVSGP----LDSLIETLL-----PKDVVDLDKEFVFSFLLSCRLFLRPHELLGRL---------L 237
            ::||.    |:.|:||.|     |.|      .|:..|||:..:|:....|:..|         :
Mosquito   482 VMSGTPQKMLEHLLETRLGGQAGPND------PFLDDFLLTHIVFMPTPLLIDELAANYHADADI 540

  Fly   238 DSVPESE--------CLESLVSLLAEWTMKFPYDYRDERMMSHVKHIVARCSNSHLEAAVSQTLS 294
            |....||        ....:|..:..|.:...:...|:.:.  |:.|....::...|.|:.:..|
Mosquito   541 DLRQASEEDQEYFLTSKRRVVQFIQRWVLAVRHAVFDDPLA--VEFIEELATDVEAEPALQEEAS 603

  Fly   295 ALLKRLTDLERHEAD--LRACQ-----------------TNDKS--GPE--------------TP 324
            .:...||.|.|::.|  :.|.|                 |:.|:  .|:              ..
Mosquito   604 IIHHVLTQLSRYQEDRQMNATQKWKLPPNGQPICLFSGNTHSKTVIRPDDDIIFRVYCADHTYCT 668

  Fly   325 LNCPTATQYAQIV--CRVEK-------------------------------KLAKHIGGEEFLQC 356
            |..|.||. |:::  |..:|                               ..|..:.|..|:..
Mosquito   669 LRFPMATT-AEVIKACAADKLQIARLPEDLLLVEVKSSGERVVFKDNDVSVPTALSLNGRIFVSP 732

  Fly   357 SSMI-----LLDKQKKWDQPSTSGAPPGAQD-------------------------------PKK 385
            ...:     |.:::...:.|.........:|                               .|.
Mosquito   733 KDHLDALTPLPEQEVPTEAPDVDFEALSTKDVAYHMTLFDWDLFWAVHEYELLYHTFGRHHFNKI 797

  Fly   386 TCNLETYLDWSARLRLFVCNEILQSVGIEGRSRTVELWSGVAQYCLLVGNYNSATAILESLESPA 450
            |.||:.::.....::.:|..||:.:..:..|...|:.:..:|.:|....|.|:..||:..|.:.|
Mosquito   798 TSNLDVFIRRFNEIQYWVVTEIVSTTNLTKRMSLVKKFIKLAAFCKEYQNLNAFFAIVMGLSNTA 862

  Fly   451 IARLKITWSKL 461
            ::||.:||.||
Mosquito   863 VSRLSMTWDKL 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	25/125 (20%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	32/197 (16%)
AgaP_AGAP007307	XP_308514.4	Crp	16..>134	CDD:223736
		CAP_ED	24..138	CDD:237999
		DEP_Epac	194..323	CDD:239884
		CAP_ED	345..456	CDD:237999
		Crp	354..>447	CDD:223736
		RasGEF_N	481..588	CDD:279012	24/113 (21%)
		RasGEF	756..996	CDD:214539	24/118 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910