DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and Rapgef1

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_006497645.1	Gene:	Rapgef1 / 107746	MGIID:	104580	Length:	1257	Species:	Mus musculus

Alignment Length:	492	Identity:	94/492 - (19%)
Similarity:	157/492 - (31%)	Gaps:	171/492 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 HRRRCRISSNSSSTDSE---SADECG----LELGESGADSREAGAGGGAGLQVAQGGIFSLDPGH 105
            |....|:.|.:|.|||.   |::|.|    :.|..||..|.|.....|.......|  ...||..
Mouse   752 HGNPVRLPSETSFTDSSEKASSEEAGGDEYVSLYSSGQTSEELAPCRGEPPSGKDG--HPRDPSV 814

  Fly   106 LTAETALLGGNIRYRRRHSAEQLSAYDLEMGFQQLELGTTISVGPKNEDLVQYDVPK----NPHK 166
            .:|.    |.:.|.....|.:.|...:.....::::   .:|:...||.:.:..:.:    .|..
Mouse   815 SSAS----GKDSRENGERSPKSLDGLESAQSEEEVD---ELSLIDHNEIMARLTLKQEGDDGPDV 872

  Fly   167 RSQCDINFESSVLGSGGIMYINGRIVSGPLDSLIETLLPKDVVDLDKEFVFSFLLSCRLFLRPHE 231
            |.           |||.|:.::.....           .||:|    .:..:||.:.|.|:.|.|
Mouse   873 RG-----------GSGDILLVHATETD-----------RKDLV----LYCEAFLTTYRTFISPEE 911

  Fly   232 LLGRLLDSVPESECLESLVSLLAEWTMKFPYDYRDERMMSHVKHIVARCSNSHL--------EAA 288
            |:.:|                          .||.|:..........|.|.:..        |..
Mouse   912 LIKKL--------------------------QYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELC 950

  Fly   289 VSQTLSALLKRLTDLERHEADLRACQTNDKSGPETPLNCPTATQYAQIVCRVEKKLAKHIGGEEF 353
            :.:....:||.|.:|                             ..::||..|..||:.:...
Mouse   951 LVELTEEILKLLMEL-----------------------------VFRLVCSGELSLARVLRKN-- 984

  Fly   354 LQCSSMILLDK--QKKW------DQPSTS---GAPPGA--------------------------- 380
                   :|||  |||.      |||..:   .|.||.
Mouse   985 -------ILDKVDQKKLLRCAHSDQPLAARGVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEIP 1042

  Fly   381 --------QDPKKTCNLETYLDWSARLRLFVCNEILQSVGIEGRSRTVELWSGVAQYCLLVGNYN 437
                    |:.:|:.||..:.:....:..:|.:.|:.....:.|.|.:..:..:.::...:.|:|
Mouse  1043 EVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFN 1107

  Fly   438 SATAILESLESPAIARLKITWSK-----LQVTCQQLD 469
            |..|||.:|:|..|.||:  |.:     |...|..:|
Mouse  1108 SYLAILSALDSAPIRRLE--WQRQTSEGLAEYCTLID 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	19/111 (17%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	40/187 (21%)
Rapgef1	XP_006497645.1	PHA03247	<227..337	CDD:223021
		PHA03307	678..>878	CDD:223039	31/145 (21%)
		RasGEFN	868..1009	CDD:214571	41/230 (18%)
		RasGEF	1016..1245	CDD:214539	23/129 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910