DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34393 and RASGRP1

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_005730.2	Gene:	RASGRP1 / 10125	HGNCID:	9878	Length:	797	Species:	Homo sapiens

Alignment Length:	317	Identity:	58/317 - (18%)
Similarity:	116/317 - (36%)	Gaps:	102/317 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   189 GRIVSG-PLDSLIETLLPKDVVDLD------KEFVFSFLLSCRLFLRPHELLGRLL----DSVPE 242
            |.:..| .||.||::.:..  .|.|      .:.:...|...|:.:...|||.:::    |::.:
Human    54 GHLAKGASLDDLIDSCIQS--FDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAK 116

  Fly   243 SE---CLESLVSLLAEWTMKFPYDYRDERMMSHVKHIVARCSNSHLEAAVSQTLSALLKRLTDLE 304
            :.   ||: :...:..|..:|...::                   ::|:::.|    ::...:|.
Human   117 NSPGLCLK-ICYFVRYWITEFWVMFK-------------------MDASLTDT----MEEFQELV 157

  Fly   305 RHEADLRACQTNDKSGPETPLNCPTATQYAQIVCRVEKKLAKHIGGEEFLQCSSMILLDKQKKWD 369
            :.:.:...|:..|    .|.:|   |..::       :||.:.|......:....:|.|.
Human   158 KAKGEELHCRLID----TTQIN---ARDWS-------RKLTQRIKSNTSKKRKVSLLFDH----- 203

  Fly   370 QPSTSGAPPGAQDPKKTCNLETYLDWSARLR------------------------LFVCNEILQS 410
                       .:|::.....|||::.:..|                        :.:||.|.|.
Human   204 -----------LEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQW 257

  Fly   411 VGIEGRSR-TVEL-------WSGVAQYCLLVGNYNSATAILESLESPAIARLKITWS 459
            |.:...|| |.:|       :..|||....:.|:|:..|::..|...:|:|||.|.|
Human   258 VQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSS 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	18/116 (16%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	32/158 (20%)
RASGRP1	NP_005730.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		RasGEFN	54..175	CDD:214571	24/150 (16%)
		Ras exchanger motif region, required for transforming activity. /evidence=ECO:0000250	57..110		12/54 (22%)
		RasGEF	201..437	CDD:214539	28/130 (22%)
		EF-hand_7	478..527	CDD:372618
		C1_1	542..591	CDD:365894
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..694
		Suppress the PT region-mediated translocation to plasma membrane. /evidence=ECO:0000250	686..694
		PT region, mediates the BCR-dependent translocation to plasma membrane. /evidence=ECO:0000250	718..797
		bZIP	<734..780	CDD:389750
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910