DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and rgl3

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_012808636.1	Gene:	rgl3 / 100485337	XenbaseID:	XB-GENE-493046	Length:	712	Species:	Xenopus tropicalis

Alignment Length:	382	Identity:	86/382 - (22%)
Similarity:	152/382 - (39%)	Gaps:	96/382 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 SGPLDSLIETLLPKDVVD---LDKEFVFSFLLSCRLFLRPHELLGRLLD---------------- 238
            :|.|..|:|.|    ||:   .|..:|.:||.:.|.|..|..:|..|||
Frog    94 AGTLQKLVENL----VVEYQGTDPTYVPTFLSTYRAFAAPERVLELLLDRRLERTSEEEHVTPGS 154

  Fly   239 SVPESECLESLV-SLLAEWTMKFPYDYRDE----RMMSHVKHIVARCSNSHLEAAVSQTLSALLK 298
            .||::..::.:| .||..|..|.|.|:||.    :::|           ::|.....:..|.||:
Frog   155 PVPDTPSVQRVVRCLLQSWLEKHPQDFRDAPDCLQLIS-----------NYLSCDKREPPSPLLR 208

  Fly   299 RLTDLERH----------EADLRACQTNDKS-GPETPLNCPTATQYAQIVCRVEKKLAKHIGGEE 352
            .|..|:..          :.:|:..:.:.:: ||...|........|:.:..::..|.:.:   :
Frog   209 LLQSLQEEMEESPTPMGSKVNLQPVEGDTETPGPTIDLLSFPPQDVAEQLTLIDVDLFQKL---Q 270

  Fly   353 FLQCSSMILLDKQKKWDQPSTSGAPPGAQDPKKTCNL-----ETYLDWSARLRLFVCNEILQSVG 412
            ...|...|       |.|          :|.|:..|:     .|...::| :...|...:|..|.
Frog   271 SCHCLGSI-------WSQ----------RDKKENRNVAPSVRATVAQFNA-VTACVIASVLSDVQ 317

  Fly   413 I--EGRSRTVELWSGVAQYCLLVGNYNSATAILESLESPAIARLKITWSKLQVTCQQLDCMQRHA 475
            :  :.|::.:|.|..:||:|..:.|::|..|||.:|:|..:.|||.||:  .|:...|:...:.:
Frog   318 LKPQQRAKVLEKWICIAQHCRFLRNFSSLRAILSALQSNPLYRLKRTWA--AVSRDNLNIFHKLS 380

  Fly   476 E------GHG---HLWQKQAISL-------NEQQEGLKTDKQAPKEPAAQGAAPTQG 516
            :      .||   .:..|:.|.|       ||.:...::..|.......||..|..|
Frog   381 DIFSDENNHGMSREILTKEEIPLRRTNSARNEPRPLQRSASQVRSTRVLQGTVPYLG 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	33/127 (26%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	34/145 (23%)
rgl3	XP_012808636.1	RasGEF_N	91..191	CDD:366199	29/100 (29%)
		RasGEF	246..517	CDD:214539	47/215 (22%)
		RA_RalGDS_like	623..708	CDD:340449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910