DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34393 and Rasgef1b

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	XP_017454916.1	Gene:	Rasgef1b / 100361238	RGDID:	1562220	Length:	543	Species:	Rattus norvegicus

Alignment Length:	565	Identity:	141/565 - (24%)
Similarity:	232/565 - (41%)	Gaps:	145/565 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 VPKNPHKRSQCDIN------FESSVLGSGGIMYINGRIVSGPLDSLIETLLPKDVVDL--DKEFV 216
            :|:.|...:..|.:      ::.|....||:.|.:..::||.|::||:.|:|.  ||.  |:.::
  Rat    71 MPQTPPFSAMFDSSGYNRNVYQPSEDSCGGLNYHDNNLLSGSLEALIQHLVPN--VDYYPDRTYI 133

  Fly   217 FSFLLSCRLFLRPHELLGRLLDSVPESECLE--------------SLVSLLAEWTMKFPYDYRDE 267
            |:||||.|||:.|:||:.::.....|.:.|.              .::.||.|||..||||:|||
  Rat   134 FTFLLSSRLFMHPYELMAKVCHLCIEHQRLSEGDGDKNQTRKIAPKILQLLTEWTETFPYDFRDE 198

  Fly   268 RMMSHVKHIVARCSNSHLEA---AVSQTLSALLKRLTDLERHE---ADLRACQTND----KSGPE 322
            |||.::|.:..|.::...:.   .|.|.:..|:::|..|.::|   |.|.:..|:.    |:.|:
  Rat   199 RMMRNLKDLAHRMASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKLSSTATDRLTVLKAKPQ 263

  Fly   323 TPLN-----CPTATQYAQIVCRVEKKLAKHIGGEEFLQC-SSMILLDKQKKWDQPSTSGAPPGAQ 381
            :...     |......||.:..:|.:...:||.|||:|. .....||..|..           ..
  Rat   264 SIQRDIMTVCSDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPLDNDKNC-----------YS 317

  Fly   382 DPKKTCNLETYLDWSARLRLFVCNEILQSVGIEGRSRTVELWSGVAQYCLLVGNYNSATAILESL 446
            :.|||.|||.|::|..||...|..||...|..:.|:|.:|.:..||:.|..:||:||..||:..:
  Rat   318 ERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNIGNFNSLMAIISGM 382

  Fly   447 ESPAIARLKITWSKLQVTCQQLDCMQRHAEGHGHLWQKQAISLNEQQEGLKTDKQAPKEPAAQGA 511
            ....::|||.||:|::..  :.|.::...:
  Rat   383 NMSPVSRLKKTWAKVKTA--KFDILEHQMD----------------------------------- 410

  Fly   512 APTQGAVAIAITTSSDSDEKPSTSGRVAGIAGISAATMESAPVPVASGSNVDAATAAAARTSTTA 576
                                                       |.::..|...|...||:.|.||
  Rat   411 -------------------------------------------PSSNFLNYRTALRGAAQRSLTA 432

  Fly   577 ATTPLASSGKPNDWVVIPVFADIVKLALGERENCLQRLANGHINMAAFDRMAAIVGAFTKHMQAM 641
            .::        .:.:|||.|:.::|......|.|:.||.|||:|...|..:|..|..|    ...
  Rat   433 HSS--------REKIVIPFFSLLIKDIYFLNEGCVNRLPNGHVNFEKFWELAKQVSEF----MTW 485

  Fly   642 KAAQAPSSGEYEHFCRHMQQTTKLGEAELMMASFDCEEP-NNAEK 685
            |..:.|...: ....:::.......|..|.:||::.|.| ||.||
  Rat   486 KQVECPFERD-RKVLQYLLSVPVFSEDALYLASYESEGPENNIEK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121	41/122 (34%)
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	45/139 (32%)
Rasgef1b	XP_017454916.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3541
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D246323at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23113
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880