DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34393 and rapgef5b

DIOPT Version :9

Sequence 1:	NP_001285578.1	Gene:	CG34393 / 33534	FlyBaseID:	FBgn0085422	Length:	691	Species:	Drosophila melanogaster
Sequence 2:	NP_001092249.1	Gene:	rapgef5b / 100073343	ZFINID:	ZDB-GENE-061215-2	Length:	341	Species:	Danio rerio

Alignment Length:	362	Identity:	77/362 - (21%)
Similarity:	125/362 - (34%)	Gaps:	105/362 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 GPETPLNCPTATQYAQIVCRV---------EKKLAKHIGGEEFLQCSSMILLDKQ---------- 365
            |.|:|       .:..:||:|         ..:|.|:  |.:|.:...:|:..|.
Zfish     4 GNESP-------SFKDLVCKVLEVHKSRTDPPRLLKN--GSQFKKNLEVIISQKPPPDSILCSNA 59

  Fly   366 -KKWDQPSTSGAPPGAQDPKKTCNLETYLDWSARLRLFVCNEILQS--VGIEGRSRTVELWSGVA 427
             :...|...:..|...|..:.........:|...::|   .:|::.  :|||    .|| |  :.
Zfish    60 GQTRHQACVNNVPCAGQALRNAVLSNCQDNWKTHVKL---AKIIRRTYIGIE----LVE-W--LM 114

  Fly   428 QYCLLVGNYNSAT---------AILESLESPAIARLKITWSKLQVT---CQQLDCMQRHAEGHGH 480
            .:|..:.|...|:         .||.|:|...|  .:.:.|..|.|   |:...|..|:...
Zfish   115 DHCEFIQNREIASKIWNVLLDLGILLSVEQNNI--FEDSRSLYQFTFKECEAQSCDFRNQVN--- 174

  Fly   481 LWQKQAISL------NEQ-----QEGLKTDKQAPKEPAAQGAAPTQGAVAIAITTSSDSDEKPST 534
             | :.|:.|      :||     |...|.|||  |.|.|  ..|.....|:...||:..:|..:.
Zfish   175 -W-RSAVHLLLQLVPHEQLCGGTQRRCKEDKQ--KTPDA--CNPVLQMRALEHFTSTVQNELLAA 233

  Fly   535 SGRVAGIAGISAATMESAPVPVASGSNVDAATAAAARTSTTAATTPLASSGKPNDWVVIPVFADI 599
            ..|.|.    :.:.||.        ||....|.....:||.|....:..:|..:.       .:|
Zfish   234 LARKAQ----TKSMMED--------SNPQHNTDTPGSSSTPAVLKQVPGAGTRDR-------EEI 279

  Fly   600 VKLALGERENCLQRLANG-----HINMAAFDRMAAIV 631
            .:|.:      :||||..     |..:...:|.|..|
Zfish   280 SRLEM------VQRLAKDGCRLLHSPLRVNERPAEFV 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34393	NP_001285578.1	REM	196..300	CDD:100121
CG34393	NP_001285578.1	RasGEF	334..>473	CDD:279011	34/172 (20%)
rapgef5b	NP_001092249.1	DEP	74..191	CDD:295306	28/133 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910