DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment toc and Mtus2

DIOPT Version :10

Sequence 1:NP_477153.1 Gene:toc / 33526 FlyBaseID:FBgn0015600 Length:2162 Species:Drosophila melanogaster
Sequence 2:NP_084196.4 Gene:Mtus2 / 77521 MGIID:1915388 Length:1353 Species:Mus musculus


Alignment Length:1692 Identity:356/1692 - (21%)
Similarity:575/1692 - (33%) Gaps:568/1692 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   412 NLTKSVIEPGDFTKVIHQGANLTLSMDQLPLLEHISMPSGLDILSSKCSGNVERPSQETDDTLDV 476
            |..:|::..||            .:.:|: :||          :||.|.   |..|::.||.|  
Mouse    24 NNNESILRTGD------------TNANQI-MLE----------VSSSCD---EAKSRDLDDEL-- 60

  Fly   477 TLTSLAPDKTNMKLP-LNSTLNTERLLDISALQSPRHIQ------LLNLTQELERGTPSRVHLQ- 533
                   ..:|:..| .:|....|          |.|:|      ....|.:.|......||.| 
Mouse    61 -------GNSNLSRPQYHSHFQKE----------PLHLQGFGKGSQAGSTSQRESQASLTVHRQL 108

  Fly   534 -------SGRRSMPQHSLLCLSPQSATTTPHGMRMMGQATPQ---------PVH---------LL 573
                   .|....||    |:...|.::..:.   :|||:|:         |.|         |.
Mouse   109 SEEHAVKRGALQAPQ----CVQGPSLSSWRNA---VGQASPEASAKKDAEIPRHIPKDKLAKTLD 166

  Fly   574 SPLLKQAQSALVL-----------------------------PTRTP----------DGDITMDG 599
            :..||:|.|....                             |.|||          .|:.|.:|
Mouse   167 NEELKRASSCSAAAGSVPPTDLQPVQLDTLGPQDHVPARGEGPQRTPASHSPGKGFSPGEGTSEG 231

  Fly   600 NG----------ALDSTLTSTSVRGRTRYSFGLDLPDTTLDCSIELVDNSFSSSTQLQQLQQQLL 654
            |.          |..|:.:.|.:.|    ..|||:.:..: ...||..:|.|:|           
Mouse   232 NSVYLPKPSTSEAKGSSPSDTKMEG----PHGLDVYNERI-THAELTPSSASAS----------- 280

  Fly   655 KKQSSFDLDESLGILTPDQMKDFLDSPHNNLMHNLEMIRMHHPNLLQLRMEQTPS-PEELPLDPI 718
                    .|:.|:..|:..   |..........|:.::..:...|.....|.|. .||..:.|:
Mouse   281 --------KENPGLRHPEVC---LGQGTGKSKVELKSVQPRNEEGLTSAQAQGPGCHEERSMSPV 334

  Fly   719 EIKSEIVKQVEASQNQVNTSQHSKLSNSFITSVTSVTSLDTGYQGDGE-----MSRPASRGACDH 778
            |.:..:.|....:.:|.|:| |.:|.....:|:..:|.:..|.:|..:     .:.||.......
Mouse   335 ERQELLEKAYREATSQGNSS-HRQLGVRRGSSLEEMTGVSAGVEGSQQATPTLSAAPAGEAGTRL 398

  Fly   779 SPSNGPHLGRVSRQPSFPPPNP-----APLRRQDPMTDSDFFTESDADDVLHRGDRRAQVIDGQL 838
            :......:||::|:.:.....|     ||:|| ||       |||...:|  .|:.| ::..|..
Mouse   399 TGKMSAGVGRMARETASGQTAPDVGQAAPVRR-DP-------TESVPSEV--SGEER-RLGSGNS 452

  Fly   839 YGPDMMQPSASVPQMEDSCMESSGIFTDVENRCDEEMRQPELEFDVDMDMSPDDSSQTMRKGQGQ 903
            ....::   ||.|....|..::||:                        :||..|:...|||:..
Mouse   453 GSTKLL---ASGPSAGGSRTDTSGL------------------------LSPRGSNLEARKGKEM 490

  Fly   904 PISTQQQQNQLAPQQRPPSSCLSSSSAATTLSQSLSNRTSYCSVDGGSARSFCGDEAFAAGRSTT 968
            ....:......|.....|:..                                 |.||       
Mouse   491 VAENRNLLENAAQTDNTPAGV---------------------------------DSAF------- 515

  Fly   969 TTAAAAAAAALSVQKTTSPRPHASLSSLCTVENFRGSVSSNSSIASPKSCKSSVTKTSAGKSRVL 1033
            :|.|.......:|..:..|.|..|.|....|  |.|...| .|:|||.:....|..|        
Mouse   516 STPAPLLHPETTVNSSHHPTPPGSSSQELGV--FSGDTGS-PSVASPPTDGGQVLNT-------- 569

  Fly  1034 KSPKSPKS-------PKSPLNRKAHTPNKWDA-------VMNKIASNKSLIKTNYNDVKSKVSTT 1084
             |||.|..       ||.|.:.| .||:..:|       .|.:.|..|.::......|:.|:.|.
Mouse   570 -SPKVPDRTTCSSGIPKPPTHPK-DTPSSQEAREKLETEKMEERAEAKPILMPKPKHVRPKIITY 632

  Fly  1085 RIMTP---ASGSSPVSGSGSGSVSRTASSPRASPSVSASARRSPSAT-----------PKVPPKM 1135
            ....|   :.|.:.:...|......|...|......:||....|||.           |:|.|..
Mouse   633 IRRNPQALSQGDASLVPVGLPYAPPTCGMPLPQEEKAASRDLQPSANMYEKLKPDLQKPRVFPSG 697

  Fly  1136 LLA---KRP----SSSSGK----VNATP------SPP--PHATPPT---RQPLDKGSVGAGSVGG 1178
            |:.   |.|    |..|.|    |...|      |||  .:..|||   ...|.|..:|.|::. 
Mouse   698 LMVSGIKPPAHHFSQMSEKFLQEVADHPGKEEFCSPPYTHYEVPPTFYRSAMLLKPQLGLGAMS- 761

  Fly  1179 GGARAVKTPKSPT-----SPTTPTTPTSPPAKRLQTSLVSRGRSYSKDSHKSSHTDLSLMCNASS 1238
                  :.|.:.:     |..:..:...||.     ||.:....|..|.     :||....|:::
Mouse   762 ------RLPSTKSRILIASQRSSASAIHPPG-----SLTTAASFYGSDP-----SDLKKASNSNA 810

  Fly  1239 SRPSNSASGSGSPKLLANTQLRAAKKRD---VRNLSISPTDLGPPPKTQQTTKGQSTRSKSSATP 1300
            ::.|...||...|   ..::|.|||...   ||:.|||..     |.:|.....|..:|:     
Mouse   811 AKASLPKSGLRPP---GYSRLPAAKLAAFGFVRSSSISAV-----PSSQSLDSVQPEQSR----- 862

  Fly  1301 TPTPTSIHKRLNGTLASTAAIATPIKGVATKSGATNK----LQQSAKTKST---ASIKSPAIVGV 1358
                                   |:    |:|...|:    |:|:..:|.|   |...:||    
Mouse   863 -----------------------PV----TRSTFGNEEQAPLKQALPSKDTPKGAGRAAPA---- 896

  Fly  1359 SEESLRSGVDQTELQELNNGQSATGCPTPPMARDSKRTSIGNELPCETEAKLKRCEDQQDPQAST 1423
                                 |::...||      :|:.:.......|.|..|: |.|:||:|..
Mouse   897 ---------------------SSSNATTP------RRSLLPAPKSTSTPAGAKK-ELQKDPEAKK 933

  Fly  1424 TASPLPMINPQEQEASGQVKEATITTANEPNALSLPDEISNSVSSTTMLATPRVDIAAQYPVLKP 1488
            .|...|              :.|.:.|.:|::...|.:.:::         ||    .::|. ||
Mouse   934 PAVSSP--------------KRTASAATKPHSPGYPKQRTSA---------PR----NEFPP-KP 970

  Fly  1489 FTENGELDCARLAKFFQDTQFERKEEQRQILGLSVMVQFMSKEL-------DAVACKENKHQCAR 1546
            ..:..|.: .:||:..:|    |.|.|.:.|||:      .:||       ||:|. ..||...:
Mouse   971 DLQAREAE-RQLAQRLRD----RCEWQARQLGLA------RRELKKAIQGFDALAV-STKHFFGK 1023

  Fly  1547 TKGTLEKTILLLQHTQKDCERLREDLEDKGLEWIQRQQEKEYLHRTELKQAEEKLMEVQLRAKLK 1611
            ::..|.|.    :....:...:|:::.....:..:.|:|||.|.|    :.||:|..:..:.:.:
Mouse  1024 SERALAKE----KELSIELANIRDEVAFNTAKCEKLQKEKETLER----RFEEELRRLGWQQQAE 1080

  Fly  1612 FCELESQLRAKDEESKQAQEAYRMEVSHK---LALKQEHLRTAEQKIQELQTRLQQVETEEQGHR 1673
            ..||:.:|    ::..||:.| |::..|:   |.::.:|        ||      |||.....|.
Mouse  1081 VQELQERL----QQQFQAESA-RLQAEHQDQLLRMRCQH--------QE------QVEDITASHE 1126

  Fly  1674 EELIRKENIHTARLA----EANQREQDLIDRVKSLTKELNTLKANKEHNERDLRDRLALSQDEIS 1734
            ..|:..||.||..:.    :.:.:.|:|:...:...|||       |.|...||..|   ||::.
Mouse  1127 AALLEMENNHTVAITILQDDHDHKVQELMSTHEFEKKEL-------EENFEKLRLTL---QDQVD 1181

  Fly  1735 VLRTSSQRRSPCTSLPDNAS------------------AELNRLTSEADSLRCVLELKQAEISAL 1781
            .|...||      ||.|.|.                  |....|..:..||:.|||:|..:|...
Mouse  1182 TLTFQSQ------SLRDRARRFEEALRKTTEEQLEIALAPYQHLEEDMQSLKQVLEMKNQQIHLQ 1240

  Fly  1782 SKAKADLIHESEERLKLSNRVALLEAQNEMLRTELEAKTEKEKEIQQKMEELQKAYKYESIKRTR 1846
            .|...:|....|:.:.|..|:.:|:.|||.|:..::..|...:::.::...||:..:.|:.::.|
Mouse  1241 EKKIIELEKLVEKNIILEERIQVLQQQNEDLKARIDQNTVVTRQLSEENANLQEYVEKETQEKKR 1305

  Fly  1847 LTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNSLSSHSRCSLGRSGLEIAVTTSSPTSPVM 1911
            |:...|||                 |..|.||...:.:.                  .||||||.
Mouse  1306 LSRTNEEL-----------------LWKLQTGDPTSPIK------------------LSPTSPVY 1335

  Fly  1912 KG 1913
            :|
Mouse  1336 RG 1337

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tocNP_477153.1 Mitofilin 1357..>1713 CDD:430783 78/369 (21%)
Smc <1545..>1838 CDD:440809 74/317 (23%)
Mtus2NP_084196.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..101 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 125..259 24/140 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 274..615 91/454 (20%)
PHA03247 <309..677 CDD:223021 94/459 (20%)
PHA03247 <516..974 CDD:223021 127/587 (22%)
Mediates interaction with MAPRE1. /evidence=ECO:0000250 626..964 92/453 (20%)
Localization to the growing distal tip of microtubules. /evidence=ECO:0000250 786..1134 104/496 (21%)
Sufficient for interaction with KIF2C. /evidence=ECO:0000250 786..874 28/137 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 799..823 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..972 38/221 (17%)
Smc 975..>1306 CDD:440809 92/385 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1315..1353 10/41 (24%)

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