Protein Alignment toc and Mtus1

DIOPT Version :10

• Sequence 1: NP_477153.1
• Gene: toc / 33526
• FlyBaseID: FBgn0015600
• Length: 2162
• Species: Drosophila melanogaster
• Sequence 2: NP_001381929.1
• Gene: Mtus1 / 306487
• RGDID: 631381
• Length: 1209
• Species: Rattus norvegicus
• Alignment Length: 1518
• Identity: 290/1518 - (19%)
• Similarity: 489/1518 - (32%)
• Gaps: 578/1518 - (38%)

  Fly   503 DISALQSPRHIQL----------LNLT----QELERGTPSRVHLQSGRRSMPQHSLLCLSPQSAT 553
            |.:...||..::|          .|.|    |.:|:|.|.|
  Rat   142 DYACGDSPETLELKQTCHMKVATANCTFIAQQAIEQGQPPR------------------------ 182

  Fly   554 TTPHGMRMMGQATPQPVHLLSPLLKQAQSALVLPTRTPDGDITM-----DGNGALDSTLTSTSVR 613
             .|.|              |.|.::. ::||....|||.....|     :||.....:|.:|
  Rat   183 -APRG--------------LQPTVRD-RNALSCSNRTPPSSSKMCVRGVNGNRENFESLQTT--- 228

  Fly   614 GRTRYSFGLDLPDTTLDCSIELVDNSFSSSTQLQQLQQQLLKKQSSFDL----DESLGILTPDQM 674
                       |..||:.:..::.:              :|.:..|.|:    ..|||.:|
  Rat   229 -----------PPKTLNTTYTVISD--------------VLMQTDSPDIGIQCQHSLGNIT---- 264

  Fly   675 KDFLDSPHNNLMHNLEMIRMHHPNLLQLRMEQTPSPEELPLDPIEIK--SEIVKQVEASQNQVNT 737
            |::.|......:...|:                 ....|..|.:|:.  |.:.|....|:...|:
  Rat   265 KEYTDGTGQGYVGEKEI-----------------QAVTLVSDGMEVPNGSVLQKFYCISEEDPNS 312

  Fly   738 SQHSKLSNSFITSVTSVTSLDTGYQGDGEMSRPASRGACDHSPSNGPHLGRVSRQPSFPPPNPAP 802
            ..||.         .|....:.|....|.:|.....|.|       |.||     |:|
  Rat   313 ETHSH---------GSYAQQEMGQNLRGSLSDGHVAGEC-------PVLG-----PAF------- 349

  Fly   803 LRRQDPMTDSDFFTESDADDVLHRGDRRAQVIDGQLYGPDMMQPSASVPQMEDSCMESSGIFTDV 867
                                    |..:.:|:|.:          ..|...||..|:|....:|:
  Rat   350 ------------------------GKSKTRVLDSE----------CKVMVTEDPHMDSQDNDSDI 380

  Fly   868 ENRCDE-----EMRQPELEFDVDMDMSPDDSSQTMRKGQGQPISTQQQQNQLAPQQRPPSSCLSS 927
            ::..:|     ..||....::|..|.|..            .|||..            ::|:|:
  Rat   381 QSSTEELTLGSVPRQRVSSYEVGWDESVG------------AISTNN------------TACVSA 421

  Fly   928 -----SSAATTLSQSLSNRTSYCSVDGGSARSFCGDEAFAAGRSTTTTAAAAAAAALSVQKTTSP 987
                 |..:.||| .:.....|.:|:.|                   ...|.:|..|..:.|..|
  Rat   422 PIRQLSDVSLTLS-PVEVTKKYNNVENG-------------------PRDAKSAPNLKGEPTNMP 466

  Fly   988 RPHASLSSLCTVENFRGSVSSNSSIASP----KSCKSSVTKTSAGKSR---VLKSPKSPKSP--K 1043
            :|:...|:..|.....|.|.....|:.|    |:.|:.|...|..:.:   ::|...:|:.|  .
  Rat   467 QPNLGKSATKTNTTIGGKVRKTEIISYPRPNFKNIKAKVISRSVLQPKDASLMKDTPNPQVPGGS 531

  Fly  1044 SP--------------------LNRKAHTP-NK-WDAVMNKIASNKSLIKTNYNDVKSKVSTTRI 1086
            ||                    .:|||..| || ....:||..::::...|.:    ||.::.|:
  Rat   532 SPTPVPSKQLTMTNKTLRSDLKADRKAEIPINKTHKQQLNKFITSQAAQVTAH----SKSASLRV 592

  Fly  1087 MTPASGS-----------SPVSGSGSGSVSRTASSPRASPSVSASARRSPSATPKVPPKMLLAKR 1140
            ...||.:           ||.:||.:|||:......:.                     :|..|.
  Rat   593 PRTASATKLNQEDVDKTGSPHAGSETGSVTAFFQKIKG---------------------ILPVKM 636

  Fly  1141 PSSSSGKV----NATPSPPPHATPPTRQPLDKGSVGAGSVGGGGARAVKTPKSP-----TSPTTP 1196
            .||...:|    :.....|.........||:|...|..::.       :|.:|.     ::|.|.
  Rat   637 KSSECLEVTYVSHIDQISPEKVEQDCEAPLEKQQRGKQAMN-------ETFESKSLFVGSAPKTS 694

  Fly  1197 TTPTSPPAKRLQTSLVSRGRSYSKDSHKSSHTDLSLMCN----ASSSRPSNSASGSGSPKLLANT 1257
            |||               |||.||....|......|...    ||..|..|.:...||.:.|:..
  Rat   695 TTP---------------GRSSSKPDSCSLRKTPGLKAKVGPAASCLRRKNDSRTLGSDRALSPQ 744

  Fly  1258 QLRAAKKRDVRNLSISPTDLGPPPKTQQTTKGQSTRSKSSATPTPTPTSIHKRLNGTLASTAAIA 1322
            ::|...... .|.||:..:..||.:..|...|                .::.:..|..|....:.
  Rat   745 RIRRVSGSG-SNASINKFEEKPPKQAFQNGSG----------------PLYLKPLGPRAHAHLLK 792

  Fly  1323 TPIKGVATKS--GATNKLQQSAKTKSTASIKSPAIVGVSEESLRSGVDQTELQELNNGQSATGCP 1385
            ||.||.:.||  .|.|.:::..:       |:|          ||...||:
  Rat   793 TPPKGPSRKSLFTAFNSVEKGRQ-------KNP----------RSLCIQTQ-------------- 826

  Fly  1386 TPPMARDSKRTSIGNELPCETEAKLKRCEDQQDPQASTTASPLPMINPQEQEASGQVKEATITTA 1450
            |.|....::||       .|......:||:|                      ||.:..
  Rat   827 TAPDVLSTERT-------LELADYKTKCENQ----------------------SGFILH------ 856

  Fly  1451 NEPNALSLPDEISNSVSSTTMLATPRVDIAAQYPVLKPFTENGELDCARLAKFFQDTQFERKEEQ 1515
                                               ||..     |.|.       :|:||
  Rat   857 -----------------------------------LKQL-----LSCG-------NTKFE----- 869

  Fly  1516 RQILGLSVMVQFMSKELDAVACKENKHQCARTKGTLEKTILLLQ----HTQKDCERL---REDLE 1573
                .|:|::|.:..|.:. |.|::|        ||.:.::.|:    .....||:|   |.||:
  Rat   870 ----ALTVVIQHLLSEREE-ALKQHK--------TLSQELVSLRGELVAASSTCEKLEKARNDLQ 921

  Fly  1574 DKGLEWIQRQQEKEYLHRTELKQ-------AE-EKLMEVQLRAKLKFCELESQLRAKDEESKQAQ 1630
            .....::|:..::....:|||:.       || |||..:.:....|:   ::||:.:.:....|.
  Rat   922 TAYEGFVQKLNQQHQTDQTELENRLKEFYTAECEKLQSIYIEEAEKY---KTQLQEQFDNLNAAH 983

  Fly  1631 EAYRMEVSHKLALKQEHL-RTAEQKIQELQTRLQQVETEEQGHREELIRKENIHTARLAEANQRE 1694
            |..::|:....:.|.|.| :|.|..:.|:          ::.|..|....||:
  Rat   984 ETTKLEIEASHSEKVELLKKTYETSLSEI----------KKSHEMEKKLLENL------------ 1026

  Fly  1695 QDLIDRVKSLTKELNTLKANKEHNERD-LRDRLALSQDEISVLRTSSQRRSPCTSLPDNASAELN 1758
              |.::.:||.|::|.||     :|.| |.:||. |:::..:.|..:..::|          ::.
  Rat  1027 --LNEKQESLEKQINDLK-----SENDALNERLK-SEEQKQLSREKANSKNP----------QVM 1073

  Fly  1759 RLTSEADSLRCVLELKQAEISALSKAKADLIHESEERL-----KLSNRVALLEAQNEMLRTELEA 1818
            .|..|.:||:.|||:|..::.     :.||.....|:|     .|.:::...:.:||.|:..::.
  Rat  1074 YLEQELESLKAVLEIKNEKLH-----QQDLKLMKMEKLVDNNTTLVDKLTRFQQENEELKARMDR 1133

  Fly  1819 KTEKEKEIQQKMEELQKAYKYESIKRTRLTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNS 1883
            .....:::..:...||::.:.||....||:.:.|||.:.|                     |:..
  Rat  1134 HMAISRQLSTEQAALQESLEKESKVNKRLSMENEELLWKL---------------------HNGD 1177

  Fly  1884 LSSHSRCSLGRSGLEIAVTTSSP 1906
            |     ||..||....|:...||
  Rat  1178 L-----CSPKRSPTSSAIPFQSP 1195

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toc	NP_477153.1	Mitofilin	1357..>1713	CDD:430783	68/371 (18%)
		Smc	<1545..>1838	CDD:440809	67/314 (21%)
Mtus1	NP_001381929.1	SMC_prok_B	<835..1154	CDD:274008	89/466 (19%)