Protein Alignment toc and Mtus1

DIOPT Version :10

• Sequence 1: NP_477153.1
• Gene: toc / 33526
• FlyBaseID: FBgn0015600
• Length: 2162
• Species: Drosophila melanogaster
• Sequence 2: NP_001390879.1
• Gene: Mtus1 / 102103
• MGIID: 2142572
• Length: 1260
• Species: Mus musculus
• Alignment Length: 1577
• Identity: 308/1577 - (19%)
• Similarity: 525/1577 - (33%)
• Gaps: 491/1577 - (31%)

  Fly   466 PSQETDDTLDVTLTSLAPDKTNMKLPLNSTLNTERLLDISALQSPRHIQLLN-LTQELERGTPSR 529
            ||:....:|.....|::....|...|....::.|  :| .|:.|...:.|.: ..:||....||.
Mouse    25 PSEYYQTSLSAQCPSVSHGDWNSDNPDAMVVDYE--MD-PAVDSSESVSLSHQCVEELAYPEPSS 86

  Fly   530 VHLQSGRRSMPQHS-LLCLSPQSATTTPHGMRMMGQATPQPVHLLSPLLKQAQSALVLPTRTPDG 593
            ..:  |:.....:| |.|.||....|          ..||.:|.....|:..|.....|
Mouse    87 DFM--GKHEFTMYSELTCQSPALVNT----------GKPQDLHSNCDSLEAIQDEKFDP------ 133

  Fly   594 DITMDGNGALDSTLTSTSVRGRTRYSFGLDLPDT-----TLDCSIELVDNSFSSSTQLQQLQQQL 653
                         |.....|....|:.| |.|:.     |....::..:.:|.:...::|.|
Mouse   134 -------------LKPCECRSDDDYACG-DSPEVLELKQTYGMKVDTANYTFIARHDIEQGQ--- 181

  Fly   654 LKKQSSFDLDESLGILTPDQMKDFLDS-----PHNNLMHNLEMIRMHHPNLLQLRMEQTPSPEEL 713
                   .|....|:.|..:.::.|.|     ||::.|: :..:..:..|...|  :.||
Mouse   182 -------PLHAPGGLQTTVRDRNALSSCGRTPPHSSKMY-VRGVNYNRENFENL--QATP----- 231

  Fly   714 PLDPIEIKSEIVKQVEASQNQVNTSQHSKLSNSFITSVTSV----TSLDTGYQGDGEMSRPASRG 774
                                       ||..|:..|.::.|    .|.|.|.||..      |.|
Mouse   232 ---------------------------SKTLNTTFTVISDVLMQTDSPDVGVQGQN------SLG 263

  Fly   775 ACDHSPSNGPHLGRVSRQ---------PSFPPPNPAPLRRQDPMTDSDFF--TESDADDVLHRGD 828
            ......::|...|.:..:         .....||.:        ...:|:  :|.|.:...|...
Mouse   264 NVTKEYTDGTRRGLIGEKEIQAVTLVSDGMEVPNGS--------ASQEFYCVSEDDPNSETHSHG 320

  Fly   829 RRAQV--------------IDGQLYGPDMMQPSASVPQMEDSCMESSGIFTDVENRCDEEMRQ-P 878
            ..||.              :||:.        ...||..|.|.....|      :.|...:.: |
Mouse   321 PYAQQEMGQNLRGTLPNCHVDGEC--------PVLVPAFEKSKTRVLG------SECKVTVTEDP 371

  Fly   879 ELE-FDVDMDMSPDDSSQTMRKGQGQ--------------PISTQQQQNQLAPQQRPPSSCLSSS 928
            .:: .|.|.|:.......|:|...||              .|.|.:......|.::||:......
Mouse   372 HIDSHDNDSDIQSSTEELTLRSVSGQRGSPYEMGWGENGGAICTDKAGCMSTPVEQPPNLSFRLE 436

  Fly   929 SAATTLSQSLSNRTSYCSVDGGSARSFCGDEAFAAGRSTTTTAAAAAAAALSVQKTTSPRPHASL 993
            .|..         ..|.:|:.|                   ...|..|..|..:.|..|:|:...
Mouse   437 PAEV---------KKYNNVENG-------------------PRDAKRAPNLKGEPTNMPKPNLGK 473

  Fly   994 SSLCTVENFRGSVSSNSSIASP----KSCKSSVTKTSAGKSR---VLKSPKSPK----SPKSPLN 1047
            |:..|.......|.....|:.|    |:.|:.|...|..:.:   ::|...||:    |..||
Mouse   474 SATKTNTTVGSKVRKTEIISYPTPNFKNIKAKVISRSVLQPKDTSIMKDTPSPQVTGGSSPSP-- 536

  Fly  1048 RKAHTPNKWDAVMNKI------ASNKSLIKTN--YNDVKSKVSTTRIMTPASGSSPVSGSGSGSV 1104
                .|:|...:|||.      ||.|:.|..|  :....:|:.|::    |:..:..|.:.|..|
Mouse   537 ----GPSKHLTMMNKAPRSDFKASKKAEIPINKTHKQQFNKLITSQ----AAQVTTHSKNASLGV 593

  Fly  1105 SRTAS-------------SPRASPSVSASARRSPSATPKVPPKMLLAKRPSSSSGKVNAT----- 1151
            .||.|             ||.|.....:.|.........:|.||       .||..:..|
Mouse   594 PRTTSATKSNQENVDKTGSPHAGSETGSVAAFFQKIKGILPVKM-------KSSECLEVTYVSHI 651

  Fly  1152 -PSPPPHATPPTRQPLDKGSVGAGSVGGGGARAVKTPKSPTSPTTPTTPTSPPAKRLQTSLVSRG 1215
             ...|.........|::|..:|..:     ...:...||....:.|.|.|:|            |
Mouse   652 DQISPEKGEQDGEAPMEKQELGKQA-----TNEIFESKSLLVGSAPKTSTTP------------G 699

  Fly  1216 RSYSKDSHKSSHTDLSLMC----NASSSRPSNSASGSGSPKLLANTQLRAAKKRDVRNLSISPTD 1276
            ||.||...:|......|..    .|:..|..:.:...||.        ||...:.:|.:|.|
Mouse   700 RSSSKPDSRSLRKTPGLKAKVGPTAACLRRKSESRTLGSD--------RALSPQRIRRVSGS--- 753

  Fly  1277 LGPPP--KTQQTTKGQSTRSKSSATPTPTPTSIHKR----LNGTLASTAAIATPIKGVATKSG-- 1333
             |.||  ||          :.||....|.|..|.:.    ..|:..|.|:..:.:...::..|
Mouse   754 -GKPPCLKT----------ALSSWVNLPRPLPISEASLICRAGSTRSVASTHSDLSAYSSDCGHA 807

  Fly  1334 ATNKLQQSAKTKSTASIKSPAIVGVSEESLRSGVDQTELQELNNGQSATGCPTPPMARDS-KRTS 1397
            |.||.::          |.|      :::.::|.....|:           |..|.|... .:||
Mouse   808 AINKYEE----------KPP------KQAFQNGSGPLYLK-----------PLVPRAHSHLLKTS 845

  Fly  1398 IGNELPCETEAKLKRCEDQQDPQASTTASPLPMINPQEQEASGQVKEATITTANEPNALSLPDEI 1462
                                 |:..:..|.....|..|:......:...|.|...|:.||
Mouse   846 ---------------------PKGPSRKSLFTAFNSVEKGRQKNPRSLCIQTQTAPDVLS----- 884

  Fly  1463 SNSVSSTTMLATPRVDIAAQYPVLKPFTENGELDCARLAKFFQDTQFERKEEQRQILGLSVMVQF 1527
                       :.|....|||.. |..:::|.:...|......:|:||         .|:|::|.
Mouse   885 -----------SERTLELAQYKT-KCESQSGFILHLRQLLSRGNTKFE---------ALTVVIQH 928

  Fly  1528 MSKELDAVACKENKHQCARTKGTLEKTILLLQ----HTQKDCERL---REDLEDKGLEWIQRQQE 1585
            :..|.:. |.|::|        ||.:.::.|:    .....||:|   |.||:....|::|:..:
Mouse   929 LLSEREE-ALKQHK--------TLSQELVSLRGELVAASSACEKLEKARTDLQTAYQEFVQKLNQ 984

  Fly  1586 KEYLHRTELKQ-------AE-EKLMEVQLRAKLKFCELESQLRAKDEESKQAQEAYRMEVSHKLA 1642
            :....||||:.       || |||..:.:....|:   ::||:.:.:....|.|..::|:....:
Mouse   985 QHQTDRTELENRLKDLYTAECEKLQSIYIEEAEKY---KTQLQEQFDNLNAAHETTKLEIEASHS 1046

  Fly  1643 LKQEHLRTAEQKIQELQTRLQQVETEEQGHREELIRKENIHTARLAEANQREQDLI-DRVKSLTK 1706
            .|.|.|:      :..:|.|.:::...:..::.|                  :||: ::.:||.|
Mouse  1047 EKVELLK------KTYETSLSEIKKSHEMEKKSL------------------EDLLNEKQESLEK 1087

  Fly  1707 ELNTLKANKEHNERD-LRDRLALSQDEISVLRTSSQRRSPCTSLPDNASAELNRLTSEADSLRCV 1770
            ::|.||     :|.| |.:||. |:::..:.|..:..::|          ::..|..|.:||:.|
Mouse  1088 QINDLK-----SENDALNERLK-SEEQKQLSREKANSKNP----------QVMYLEQELESLKAV 1136

  Fly  1771 LELKQAEISALSKAKADLIHESEERLK-----LSNRVALL------EAQNEMLRTELEAKTEKEK 1824
            ||:|.           :.:|:.:.:|.     :.|..||:      :.:||.|:..::......:
Mouse  1137 LEIKN-----------EKLHQQDMKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISR 1190

  Fly  1825 EIQQKMEELQKAYKYESIKRTRLTYDKEELQYHLKQRSLQLQSAESKLQDLSTGSHDNSLSSHSR 1889
            ::..:...||::.:.||....||:.:.|||.:.|                     |:..|
Mouse  1191 QLSTEQAALQESLEKESKVNKRLSMENEELLWKL---------------------HNGDL----- 1229

  Fly  1890 CSLGRSGLEIAVTTSSP 1906
            ||..||....|:...||
Mouse  1230 CSPKRSPTSSAIPFQSP 1246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
toc	NP_477153.1	Mitofilin	1357..>1713	CDD:430783	72/372 (19%)
		Smc	<1545..>1838	CDD:440809	66/320 (21%)
Mtus1	NP_001390879.1	SMC_prok_B	<905..1205	CDD:274008	77/371 (21%)