Protein Alignment Prp40 and PRPF40A

DIOPT Version :10

• Sequence 1: NP_608738.1
• Gene: Prp40 / 33513
• FlyBaseID: FBgn0031492
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: NP_001382417.1
• Gene: PRPF40A / 55660
• HGNCID: 16463
• Length: 994
• Species: Homo sapiens
• Alignment Length: 943
• Identity: 381/943 - (40%)
• Similarity: 522/943 - (55%)
• Gaps: 173/943 - (18%)

  Fly     5 PSVG--NGGAPPGR-GIGYTP---------------PGAIVPQFPPPGFGAPP------------ 39
            |..|  .||...|. |:.|.|               |..::||..|| .|.||
Human    82 PGTGAERGGLMMGHPGMHYAPMGMHPMGQRANMPPVPHGMMPQMMPP-MGGPPMGQMPGMMSSVM 145

  Fly    40 -----------------PPEL----AAAFGVMATSTEWTEHKAPDGRPYYYNQNTKQSSWEKPEA 83
                             ||.:    .||.......:.|||||:||||.||||..||||:||||:.
Human   146 PGMMMSHMSQASMQPALPPGVNSMDVAAGTASGAKSMWTEHKSPDGRTYYYNTETKQSTWEKPDD 210

  Fly    84 LMTPAELLHNQCPWKEYRSDTGKVYYHNVATKETCWEPPPEYVDMK------------------A 130
            |.||||.|.::||||||:||:||.||:|..|||:.|..|.|..|::                  |
Human   211 LKTPAEQLLSKCPWKEYKSDSGKPYYYNSQTKESRWAKPKELEDLEGYQNTIVAGSLITKSNLHA 275

  Fly   131 KAKAEEAA-------------------------AAAKAVAAMTSSSLAGMVPPAA--------LA 162
            ..||||::                         |||:|.||:.:::.|.....||        .:
Human   276 MIKAEESSKQEECTTTSTAPVPTTEIPTTMSTMAAAEAAAAVVAAAAAAAAAAAAANANASTSAS 340

  Fly   163 SILPAALPVAPRLPTPEIHSPL-TPSSNEN--SSSAMDQAMAATLAAI-----EVPQQNAKKDDK 219
            :.:...:||   :|.||:.|.: |...|||  :.|..:||...:..||     ||.....::..|
Human   341 NTVSGTVPV---VPEPEVTSIVATVVDNENTVTISTEEQAQLTSTPAIQDQSVEVSSNTGEETSK 402

  Fly   220 SESAVVFKDKREAIES------------------FKELLRDRNVPSNANWDQCVKIISKDPRYAA 266
            .|:...|..|:|..||                  |||||:::.|||||:|:|.:|:|..||||:|
Human   403 QETVADFTPKKEEEESQPAKKTYTWNTKEEAKQAFKELLKEKRVPSNASWEQAMKMIINDPRYSA 467

  Fly   267 FKNLNERKQTFNAYKTQKIKDEREESRLKAKKAKEDLEQFLMSSDKMNSQMKYFRCEEVFAGTRT 331
            ...|:|:||.|||||.|..|:|:||:|.|.|:|||..::||.:.:||.|..:|.:.|::|.....
Human   468 LAKLSEKKQAFNAYKVQTEKEEKEEARSKYKEAKESFQRFLENHEKMTSTTRYKKAEQMFGEMEV 532

  Fly   332 WTAVPEPDRRDIYEDCIFNLAKREKEEARLLKKRNMKVLGELLESMTSINHATTWSEAQVMLLDN 396
            |.|:.|.||.:||||.:|.|:|:|||:|:.|:|||.:.|..:|::|.::.::|||||||..|:||
Human   533 WNAISERDRLEIYEDVLFFLSKKEKEQAKQLRKRNWEALKNILDNMANVTYSTTWSEAQQYLMDN 597

  Fly   397 VAFKNDVTLLGMDKEDALIVFEEHIRTLEKEEDEEREREKKRMKRQQRKNRDSFLALLDSLHEEG 461
            ..|..|..|..||||||||.||||||.|||||:||:::...|.:|:|||||:||...||.|||.|
Human   598 PTFAEDEELQNMDKEDALICFEEHIRALEKEEEEEKQKSLLRERRRQRKNRESFQIFLDELHEHG 662

  Fly   462 KLTSMSLWVELYPIISADLRFSAMLGQSGSTPLDLFKFYVENLKARFHDEKKIIREILKEKAFVV 526
            :|.|||.|:||||.||:|:||:.||||.|||.|||||||||:||||:|||||||::|||:|.|||
Human   663 QLHSMSSWMELYPTISSDIRFTNMLGQPGSTALDLFKFYVEDLKARYHDEKKIIKDILKDKGFVV 727

  Fly   527 QAKTSFEDFATVVCEDKRSASLDAGNVKLTYNSLLEKAEAIEKERMKEEVRRLRKLENEIKNEWL 591
            :..|:||||..::...|||.:|||||:||.:|||||||||.|:||.|||.|::::.|:..|:...
Human   728 EVNTTFEDFVAIISSTKRSTTLDAGNIKLAFNSLLEKAEAREREREKEEARKMKRKESAFKSMLK 792

  Fly   592 EA--NVSVAEPYESAKKLVEHLEAFALYEKEIGVEKIWEDFVKESEDACSHHHSRSRK-SKKNKK 653
            :|  .:.:...:|..::......||.....|...::|::||:...|..|.||||:::| |||:||
Human   793 QAAPPIELDAVWEDIRERFVKEPAFEDITLESERKRIFKDFMHVLEHECQHHHSKNKKHSKKSKK 857

  Fly   654 H---KKRVRSVSRSDIENEHIEVEKSKRRRSKTRSHSLTSIGSIESEKLLKKKKKRKNKLRGSSC 715
            |   :.|.||.|.||.::.|   .|.||:||::||.|..| .|.|||:..||.||.|.|.:....
Human   858 HHRKRSRSRSGSDSDDDDSH---SKKKRQRSESRSASEHS-SSAESERSYKKSKKHKKKSKKRRH 918

  Fly   716 ESDVPGIQSPGTQALLQNDSNSHSPAKKKKKEKRAKKDKRHNRHNRSGTPLSPAQSV-------E 773
            :||.|               .|.:..:|.||||..:.:|...|........||.:..       :
Human   919 KSDSP---------------ESDAEREKDKKEKDRESEKDRTRQRSESKHKSPKKKTGKDSGNWD 968

  Fly   774 SSGSRNEELTLSDGELESKRAALLAQLSEQLDE 806
            :|||.     ||:||||.:|..||    ||||:
Human   969 TSGSE-----LSEGELEKRRRTLL----EQLDD 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp40	NP_608738.1	PRP40	54..634	CDD:227435	293/658 (45%)
PRPF40A	NP_001382417.1	PRP40	174..833	CDD:227435	291/661 (44%)