Protein Alignment Prp40 and Prpf40b

DIOPT Version :10

• Sequence 1: NP_608738.1
• Gene: Prp40 / 33513
• FlyBaseID: FBgn0031492
• Length: 806
• Species: Drosophila melanogaster
• Sequence 2: XP_011243999.1
• Gene: Prpf40b / 54614
• MGIID: 1925583
• Length: 903
• Species: Mus musculus
• Alignment Length: 899
• Identity: 359/899 - (39%)
• Similarity: 508/899 - (56%)
• Gaps: 137/899 - (15%)

  Fly     3 VPPSVGNGGAPP----GRGIGYTPPGAIVPQFPPPGFGAPPP--------PEL------------ 43
            :||.....|.||    ...|...|||.:.|..||  .|||||        |.:
Mouse    41 LPPPFPPMGLPPMSQRPPAIPPMPPGILPPMLPP--MGAPPPLTQIPGMVPPMMPGMLMPAVPVT 103

  Fly    44 -AAAFGVMATSTE----------WTEHKAPDGRPYYYNQNTKQSSWEKPEALMTPAELLHNQCPW 97
             |.|.|....|:.          |:||.|||||.||||.:.|||.||||..|.:.||||.:||||
Mouse   104 AATAPGADTASSAVAGTGPPRALWSEHVAPDGRIYYYNADDKQSVWEKPSVLKSKAELLLSQCPW 168

  Fly    98 KEYRSDTGKVYYHNVATKETCWEPPPEYVDMKAKAKAEEAAAAAKAVAAMTSSSLAGMVPPAALA 162
            |||:|||||.||:|..::|:.|..|.:..|::|..|.|.|       ....:..|..:.|.....
Mouse   169 KEYKSDTGKPYYYNNQSQESRWTRPKDLDDLEALVKQESA-------GKQQTQQLQTLQPQPPQP 226

  Fly   163 SILPAALPVAPRLPTPEIHSPLTPSSNEN-----SSSAMDQAM-------AATLAAIEVPQQNAK 215
            ...|..:|..| :|.|.......|..:|:     ::..::|..       :::......||:..:
Mouse   227 QPDPPPIPPGP-IPVPMALLEPEPGRSEDCDVLEAAQPLEQGFLQREEGPSSSTGQHRQPQEEEE 290

  Fly   216 -KDDKSESAVVFKDKREAIESFKELLRDRNVPSNANWDQCVKIISKDPRYAAFKNLNERKQTFNA 279
             |.:...|.:.:.::.:|.::|||||||:.|||||:|:|.:|::..||||:|...|:|:||.|||
Mouse   291 AKPEPERSGLSWSNREKAKQAFKELLRDKAVPSNASWEQAMKMVVTDPRYSALPKLSEKKQAFNA 355

  Fly   280 YKTQKIKDEREESRLKAKKAKEDLEQFLMSSDKMNSQMKYFRCEEVFAGTRTWTAVPEPDRRDIY 344
            ||.|:.|:|:||:||:||:||:.|:.||...::|.|..:|.|.|:.|.....|..|||.:|:::|
Mouse   356 YKAQREKEEKEEARLRAKEAKQTLQHFLEQHERMTSTTRYRRAEQTFGDLEVWAVVPERERKEVY 420

  Fly   345 EDCIFNLAKREKEEARLLKKRNMKVLGELLESMTSINHATTWSEAQVMLLDNVAFKNDVTLLGMD 409
            :|.:|.|||:|||:|:.|::||::.|..:|:.|:|:|..||||:||..|:||.:|..|..|..||
Mouse   421 DDVLFFLAKKEKEQAKQLRRRNIQALKSILDGMSSVNFQTTWSQAQQYLMDNPSFAQDQQLQNMD 485

  Fly   410 KEDALIVFEEHIRTLEKEEDEEREREKKRMKRQQRKNRDSFLALLDSLHEEGKLTSMSLWVELYP 474
            ||||||.||||||.||:||:|||||.:.|.:|||||||::|.:.||.|||.|:|.|||.|:||||
Mouse   486 KEDALICFEEHIRALEREEEEERERARLRERRQQRKNREAFQSFLDELHETGQLHSMSTWMELYP 550

  Fly   475 IISADLRFSAMLGQSGSTPLDLFKFYVENLKARFHDEKKIIREILKEKAFVVQAKTSFEDFATVV 539
            .:|.|:||:.||||.|||||||||||||.||||||||||||::|||::.|.|:..|:|||||.|:
Mouse   551 AVSTDVRFANMLGQPGSTPLDLFKFYVEELKARFHDEKKIIKDILKDRGFCVEVNTAFEDFAHVI 615

  Fly   540 CEDKRSASLDAGNVKLTYNSLLEKAEAIEKERMKEEVRRLRKLENEIKNEWLEANVSVAEPYESA 604
            ..|||:|:|||||:|||:|||||||||.|:||.|||.||:|:.|...:: .|...|...|...:.
Mouse   616 SFDKRAAALDAGNIKLTFNSLLEKAEAREREREKEEARRMRRREAAFRS-MLRQAVPALELGTAW 679

  Fly   605 KKLVEHLEAFALYEKEIGVE----KIWEDFVKESEDA-CSHHHSRSRK-SKKNKK-HKKRVR--S 660
            :::.|.....:.:| :|.:|    :::.:|::..|.. |.|.|::.|| .:|.|| |:||..  |
Mouse   680 EEVRERFVCDSAFE-QITLESERIRLFREFLQVLEQTECQHLHTKGRKHGRKGKKHHRKRSHSPS 743

  Fly   661 VSRSDIENEHIE-----VEKSKRRR---SKTRSHSLTSIGSIESEKLLKKKKKRKNKLRGSSCES 717
            |||...|::..|     :...||||   |::.|...:|:.|:||               |.:.
Mouse   744 VSRQGSESDEEELPPPSLRPPKRRRRNPSESGSEPSSSLDSVES---------------GGAA-- 791

  Fly   718 DVPGIQSPGTQALLQNDSNSHSPAKKKKKEKRAKKDKRHNRHNRSGTPLSPAQSVESSGSRNE-- 780
             :.|..||.:..||.:|   |...|.||.:|:.||     |.::|.:|.|.....:.:|..:|
Mouse   792 -LGGPGSPSSHLLLGSD---HGLRKTKKPKKKTKK-----RRHKSTSPDSETDPEDKAGKESEDR 847

  Fly   781 --------------------------------ELTLSDGELESKRAALLAQLSE 802
                                            |..||:||||.:|..||.||.:
Mouse   848 EQEQDREPRQAELPNRSPGFGIKKEKTGWDTSESELSEGELERRRRTLLQQLDD 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Prp40	NP_608738.1	PRP40	54..634	CDD:227435	277/606 (46%)
Prpf40b	XP_011243999.1	PRP40	118..>610	CDD:227435	233/499 (47%)
		FF	662..710	CDD:128718	8/49 (16%)