DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ccdc85 and Ccdc85c

DIOPT Version :9

Sequence 1:	NP_608734.2	Gene:	Ccdc85 / 33509	FlyBaseID:	FBgn0031488	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_006516221.1	Gene:	Ccdc85c / 668158	MGIID:	3644008	Length:	433	Species:	Mus musculus

Alignment Length:	450	Identity:	152/450 - (33%)
Similarity:	220/450 - (48%)	Gaps:	96/450 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 PPDIPQLSSIYIPDSIKQQQQQQQQQQSRYLPAHQPGAKDMLKFVRKPDQEHPSPNASVTSSGTG 275
            ||.:...::....:.:.|...::..:.|:         :::.:.:|:.:.|.           .|
Mouse     4 PPAVAAAAAAAASEELSQVPDEELLRWSK---------EELARRLRRAEGEK-----------VG 48

  Fly   276 IPTANGGGRLTAEQNRQLQSLVNELRALKEQNQRLLDDNQELRDLCCFLDDDRQKGRKLAREWQR 340
            :...:||  |..:.||:||..:.|:|.||:.||||.|||||||:|||||||||||||||||||||
Mouse    49 LMLEHGG--LMRDVNRRLQQHLLEIRGLKDVNQRLQDDNQELRELCCFLDDDRQKGRKLAREWQR 111

  Fly   341 FGRYTASVMRQEVAAYQNKLRQLDDKQQELITDNLELKELCLYLDEERAHVAA--NALCAGCGAA 403
            |||:.|..:..|||..|.|||:|:.:|:.|:.:|||||||.|.||||||.:||  .|...|.||.
Mouse   112 FGRHAAGAVWHEVARSQQKLRELEARQEALLRENLELKELVLLLDEERAALAAAGGAGGGGGGAG 176

  Fly   404 TRNAL-------------------RDDGDGSSSSTNA------------------------DETI 425
            :|:::                   ||.|||||:|:..                        |...
Mouse   177 SRSSIDSQASLSGPLAGSAAGSGARDVGDGSSTSSAGSGGSPDHHHHVPAALLPPGPHKVPDGKA 241

  Fly   426 TALRNYAEQRQLPQDLRH-AHTLNDQTLQYVRSLERRIQQLEEERTTPTAHLQQPTTPTPQATPT 489
            .|.|...:....|...|. .:.|:|.:..|:|.||.:::.|:.::.       .|..|.|.:...
Mouse   242 GATRRSLDDLSAPPHHRSIPNGLHDPSSTYIRPLETKVKLLDGDKL-------PPQLPRPHSCQR 299

  Fly   490 PTVTSAAT----PAKSAASPHQQQQQQQQHQQQQQDIVAAAAAAAAAIQLPEP------IAG-RP 543
            ..:..|.:    ..:...||:..:.|........|:::....|.... :||.|      .|| :|
Mouse   300 SQLQQAGSGEFRTLRKGFSPYHSESQLASLPPSYQEVLQNGPACPVP-ELPSPPSTVYSSAGQKP 363

  Fly   544 EAVVRALQVLEVREQLERDRLGNLAGSALDQMDDGEKALVREMCNVVWRKLEGSPHGPAA 603
            ||||.|::||||.|.|:|    .|..|..:.:.:.|||:||||||||||||     |.||
Mouse   364 EAVVHAMKVLEVHENLDR----QLQDSCEEDLSEKEKAIVREMCNVVWRKL-----GDAA 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ccdc85	NP_608734.2	DUF2216	<283..389	CDD:287229	67/105 (64%)
Ccdc85c	XP_006516221.1	CCDC85	16..203	CDD:370898	84/208 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	152	1.000	Domainoid score	I4302
eggNOG	1	0.900	-	-		E1_KOG3819
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H82238
Inparanoid	1	1.050	196	1.000	Inparanoid score	I3802
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1393196at2759
OrthoFinder	1	1.000	-	-		FOG0002221
OrthoInspector	1	1.000	-	-		otm44298
orthoMCL	1	0.900	-	-		OOG6_108799
Panther	1	1.100	-	-	LDO	PTHR13546
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3355
SonicParanoid	1	1.000	-	-		X1655
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.860