Protein Alignment okr and Chd8

DIOPT Version :10

• Sequence 1: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_963999.2
• Gene: Chd8 / 67772
• MGIID: 1915022
• Length: 2582
• Species: Mus musculus
• Alignment Length: 839
• Identity: 221/839 - (26%)
• Similarity: 365/839 - (43%)
• Gaps: 190/839 - (22%)

  Fly    26 LKKNKRSCQQELEREQELDRRRLGALRDASNTSELPLPIRFTANSEYELAIAKVLARKFKVPMDN 90
            |:|:|| ..|:|:|    .:.::..:|...:..|.|.      |.:| :.:.::|.....|..||
Mouse   690 LEKDKR-IHQKLKR----FKTKMAQMRHFFHEDEEPF------NPDY-VEVDRILDESHSVDKDN 742

  Fly    91 YVP----------------------DYGGKRVLGVRRCISRRP----LHDPMACNA---LVLFHP 126
            ..|                      |....::...:|..||.|    ::.|.| ||   |.|.|
Mouse   743 GEPVIYYLVKWCSLPYEDSTWELKEDVDEGKIREFKRIQSRHPELRRVNRPQA-NAWKKLELSH- 805

  Fly   127 PAYTEHERMGMDPTKVLVHVVVDPLLSNILRPHQREGVRFM----YECVEGKRGNFNGCIMADEM 187
                |::.                  .|.||.:|.|||.::    |        |...||:||||
Mouse   806 ----EYKN------------------RNQLREYQLEGVNWLLFNWY--------NRQNCILADEM 840

  Fly   188 GLGKTLQCVTL---VWTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWLHGRLLCLPMEGGT 249
            |||||:|.:..   |:.:...||        .:|::|.|.:.|||:||..|             |
Mouse   841 GLGKTIQSIAFLQEVYNVGIHGP--------FLVIAPLSTITNWEREFNTW-------------T 884

  Fly   250 KENTI---------RALEQFSM----TSARL--GT---PVLLISYETFRIYAEILCKYEVGMVIC 296
            :.|||         :.::|:.|    :..||  |.   ..|:.::|........|.:.|...||.
Mouse   885 EMNTIVYHGSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPELREIEWRCVII 949

  Fly   297 DEGHRLKNSDNLTYQALMGLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESA 361
            ||.|||||.:.....:|..:..:.:|||:|||:||.:.|.:||::|:.|....:.:.|.::|...
Mouse   950 DEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFGDL 1014

  Fly   362 ILRGQNTDSTEQERQRAIEKTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYT 426
                    .||       |:.|:|..::...::||..:.:.|.|..|.|.:|..:||.||.:.|.
Mouse  1015 --------KTE-------EQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYR 1064

  Fly   427 NFLKSDQVRRSLADCNEKASLTALADITT----LKKICSHPDLIYEKLTAREK---GFENSQNVL 484
            ..|:     ::.:..::.|..|.:.::..    |:|.|:||.||.   .|.||   .|..:.:::
Mouse  1065 AILE-----KNFSFLSKGAGHTNMPNLLNTMMELRKCCNHPYLIN---GAEEKILMEFREACHII 1121

  Fly   485 PSNYKPKDLNPELSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGT 549
            |.::..:.: ...:||.:|:|.:|..::| |..||::.|...:.||:.|....:|:|.:.|:||.
Mouse  1122 PQDFHLQAM-VRSAGKLVLIDKLLPKLKA-GGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGR 1184

  Fly   550 MSIKKRSKVVDRFNDPESDSFLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDG 614
            :....|...:|||:.|:||.|:|:|.::|||.|:||..|:...:||.||||.||.||.||..|.|
Mouse  1185 VRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIG 1249

  Fly   615 QKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTII------DNNESAEKHFTRDDLKDLFTFDAN 673
            |.|...:|||:...|.|.::..:.:.|..|...::      |.|.:..:.|::.:::||....|.
Mouse  1250 QSKAVKVYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRDGNITGIQQFSKKEIEDLLRKGAY 1314

  Fly   674 ILSDTHDKLKCKRCVQNIQMKPPPEDTDCT--------SHLSQWYHCSNNR---GLPDNILAQAW 727
            ......|....|.|.::|........|..|        :.....:..|.||   .|.|....|.|
Mouse  1315 AAIMEEDDEGSKFCEEDIDQILLRRTTTITIESEGKGSTFAKASFVASENRTDISLDDPNFWQKW 1379

  Fly   728 ------------------MDCKCVSFVFHHRS--QAQEIVPSAEEEATDQPEEKPESRK 766
                              :|...|.....|.|  :..::|..::.|:.|  :|:|.||:
Mouse  1380 AKKADLDMDLLNSKNNLVIDTPRVRKQTRHFSTLKDDDLVEFSDLESED--DERPRSRR 1436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137	16/78 (21%)
		HepA	<156..650	CDD:440319	160/531 (30%)
		DEXHc_RAD54A	156..396	CDD:350825	75/264 (28%)
Chd8	NP_963999.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..111
		SP1-4_N	61..>421	CDD:425404
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	136..155
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..283
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..377
		PTZ00121	<449..624	CDD:173412
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..585
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	598..617
		CD1_tandem_CHD5-9_like	640..705	CDD:349315	7/19 (37%)
		CD2_tandem_CHD5-9_like	723..781	CDD:349310	8/58 (14%)
		PLN03142	812..>1411	CDD:215601	182/652 (28%)
		DEAD-like_helicase_N	813..1034	CDD:475120	75/264 (28%)
		DEAH box. /evidence=ECO:0000255|HAMAP-Rule:MF_03071	950..953		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1694..1715
		Interaction with FAM124B. /evidence=ECO:0000255|HAMAP-Rule:MF_03071	1791..2304
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1990..2019
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2045..2120
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2187..2233
		BRK	2311..2354	CDD:462196
		BRK	2381..2420	CDD:470653
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2486..2582