Protein Alignment okr and ATRX

DIOPT Version :10

• Sequence 1: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_000480.3
• Gene: ATRX / 546
• HGNCID: 886
• Length: 2492
• Species: Homo sapiens
• Alignment Length: 963
• Identity: 256/963 - (26%)
• Similarity: 404/963 - (41%)
• Gaps: 283/963 - (29%)

  Fly    14 RPESRHSFTPPLLKKNKRSCQQELEREQELDRRRLGALRDASNTSELPLPIRFTANSEYE----- 73
            ||.:| |.....|::|:||.:|:.:      |||:....|:|:.::        :|||.|
Human  1401 RPRTR-SAKKAELEENQRSYKQKKK------RRRIKVQEDSSSENK--------SNSEEEEEEKE 1450

  Fly    74 ---------------------------LAIAKVLA-RKFKVPMDNYVPDYGGKRVLGVRRCISRR 110
                                       ..|.|:|. .|.:....|.:.:...:|.....|...|.
Human  1451 EEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAERERERE 1515

  Fly   111 PLHDPMACNALVLFHPPAYTEHERMGMDPTK--VLVHVVVD-------PLLS---NI---LRPHQ 160
            .|.:.:                |.....|||  :...:|:|       ||:.   |:   |:|||
Human  1516 KLREVI----------------EIEDASPTKCPITTKLVLDEDEETKEPLVQVHRNMVIKLKPHQ 1564

  Fly   161 REGVRFMYECV-----EGKRGNFNGCIMADEMGLGKTLQCVTLVWTLLRQGPEC-KPTINKAIVV 219
            .:||:||::|.     :.|:...:|||:|..||||||||.|:.:.|:|.    | |...:.|:||
Human  1565 VDGVQFMWDCCCESVKKTKKSPGSGCILAHCMGLGKTLQVVSFLHTVLL----CDKLDFSTALVV 1625

  Fly   220 SPSSLVKNWEKEFTKWLHGRLLCLPMEGGTKEN---------TIRALEQFSMTSARLGTP--VLL 273
            .|.:...||..||.||          :.|.|::         |::..::.|....|....  |::
Human  1626 CPLNTALNWMNEFEKW----------QEGLKDDEKLEVSELATVKRPQERSYMLQRWQEDGGVMI 1680

  Fly   274 ISYETFRIYA-----------EILCKYEV----GMVICDEGHRLKNSDNLTYQALMGLKTKRRVL 323
            |.||.:|..|           ||..|..|    ..|:|||||.|||..:...:|:..::::||::
Human  1681 IGYEMYRNLAQGRNVKSRKLKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSIRSRRRII 1745

  Fly   324 LSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIGL 388
            |:|||:||:|.||:.:|||:...:||:...|:..|.:.|..||..|||..:.:...::...|..:
Human  1746 LTGTPLQNNLIEYHCMVNFIKENLLGSIKEFRNRFINPIQNGQCADSTMVDVRVMKKRAHILYEM 1810

  Fly   389 VDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFLKS-DQVRRSLADCNEKASLTALAD 452
            :..|:.|:....|||:||.|.|.|:..::|:||.:||..:|.. ..|..:......||......|
Human  1811 LAGCVQRKDYTALTKFLPPKHEYVLAVRMTSIQCKLYQYYLDHLTGVGNNSEGGRGKAGAKLFQD 1875

  Fly   453 ITTLKKICSHP-DLIYEKLTAREKGF---------------ENSQNVLPSNYKPK---------- 491
            ...|.:|.:|| .|..:.::...||:               |.|.::...:|..|
Human  1876 FQMLSRIWTHPWCLQLDYISKENKGYFDEDSMDEFIASDSDETSMSLSSDDYTKKKKKGKKGKKD 1940

  Fly   492 --------------------------------------------------DLNP----------- 495
                                                              ..||
Human  1941 SSSSGSGSDNDVEVIKVWNSRSRGGGEGNVDETGNNPSVSLKLEESKATSSSNPSSPAPDWYKDF 2005

  Fly   496 ---------ELSGKFMLLDFMLAAIRAEGNDKVVLISNYTQTLDLFE---QLARK---------- 538
                     |.|||.:|| |.:..:..|..|||::.|....:|||.|   :||.:
Human  2006 VTDADAEVLEHSGKMVLL-FEILRMAEEIGDKVLVFSQSLISLDLIEDFLELASREKTEDKDKPL 2069

  Fly   539 ---------RKYGFVRLDGTMSIKKRSKVVDRFNDPES-DSFLFMLSSKAGGCGLNLIGANRLFM 593
                     |...:.||||:.:.:.|.|..:.|||..: ...||::|:|||..|:||:.|||:.:
Human  2070 IYKGEGKWLRNIDYYRLDGSTTAQSRKKWAEEFNDETNVRGRLFIISTKAGSLGINLVAANRVII 2134

  Fly   594 FDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSSTIIDNNESAEKH 658
            ||..|||:.|.|::.||:|.||.||.|:||.:|.|::|:||..||..|:|||..::| .:..|:|
Human  2135 FDASWNPSYDIQSIFRVYRFGQTKPVYVYRFLAQGTMEDKIYDRQVTKQSLSFRVVD-QQQVERH 2198

  Fly   659 FTRDDLKDLFTFDANILSDTHDKLKCKRCVQNIQMKPPPEDTDCTSHLSQWYHCSNNRGLP-DNI 722
            ||.::|.:|:||:.::|.|.:.:.|.||            ||..               || |.|
Human  2199 FTMNELTELYTFEPDLLDDPNSEKKKKR------------DTPM---------------LPKDTI 2236

  Fly   723 LAQAWMDCKCVSFVFHHRSQAQEIVPSAEEEATDQPEEKP-----ESRKRSST 770
            ||:. :.......|.:|  :...::...|||...:.|.|.     |:.|:..|
Human  2237 LAEL-LQIHKEHIVGYH--EHDSLLDHKEEEELTEEERKAAWAEYEAEKKGLT 2286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137	9/50 (18%)
		HepA	<156..650	CDD:440319	188/645 (29%)
		DEXHc_RAD54A	156..396	CDD:350825	88/271 (32%)
ATRX	NP_000480.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..147
		ADDz_ATRX	167..270	CDD:277252
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..516
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..576
		PxVxL motif	581..594
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	593..616
		PTZ00108	<642..857	CDD:240271
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	649..956
		PTZ00121	<791..1438	CDD:173412	14/43 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	968..1479		18/92 (20%)
		Interaction with DAXX	1189..1326
		HepA	<1543..2191	CDD:440319	191/662 (29%)
		DEXHc_ATRX	1560..1803	CDD:350826	86/256 (34%)
		DEGH box	1719..1722		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1913..2000		6/86 (7%)
		Interaction with MECP2. /evidence=ECO:0000269|PubMed:17296936	2010..2280		97/301 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2462..2492