Protein Alignment okr and CHD5

DIOPT Version :10

• Sequence 1: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_056372.1
• Gene: CHD5 / 26038
• HGNCID: 16816
• Length: 1954
• Species: Homo sapiens
• Alignment Length: 653
• Identity: 195/653 - (29%)
• Similarity: 309/653 - (47%)
• Gaps: 94/653 - (14%)

  Fly   147 VVDPLL------------SNILRPHQREGVRFM-YECVEGKRGNFNGCIMADEMGLGKTLQCVTL 198
            :|||.:            ...|.|:|.||:.:: :...:|     ...|:|||||||||:|.:..
Human   679 IVDPTVKFDKQPWYIDSTGGTLHPYQLEGLNWLRFSWAQG-----TDTILADEMGLGKTVQTIVF 738

  Fly   199 VWTLLRQGPECKPTINKAIVVSPSSLVKNWEKEFTKWL------------HGRLLCLPMEGGTKE 251
            :::|.::|....|    .:|.:|.|.:.|||:||..|.            ..|.:....|...::
Human   739 LYSLYKEGHSKGP----YLVSAPLSTIINWEREFEMWAPDFYVVTYTGDKESRSVIRENEFSFED 799

  Fly   252 NTIRALEQ-FSM-TSARLGTPVLLISYETFRIYAEILCKYEVGMVICDEGHRLKNSDNLTYQALM 314
            |.||:.:: |.| ...::...|||.|||...|...||...|...::.||.|||||:.:..::.|.
Human   800 NAIRSGKKVFRMKKEVQIKFHVLLTSYELITIDQAILGSIEWACLVVDEAHRLKNNQSKFFRVLN 864

  Fly   315 GLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAI 379
            ..|...::||:|||:||:|.|.:.|:||:.||.......|...|         .|.:::::   |
Human   865 SYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEF---------ADISKEDQ---I 917

  Fly   380 EKTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFL-KSDQVRRSLADCNE 443
            :|..:|:|   ..::||....:.|.:|.|.|:::..:|:.:|.:.|...| ::.:...|....|:
Human   918 KKLHDLLG---PHMLRRLKADVFKNMPAKTELIVRVELSQMQKKYYKFILTRNFEALNSKGGGNQ 979

  Fly   444 KASLTALADITTLKKICSHPDLIYEKLTAREKGFENSQNVLPS-NYKPKDLNPELSGKFMLLDFM 507
            .:.|..:.|   |||.|:||.|.  .:.|.|      ..|||: :|....| .:.|||.|||..|
Human   980 VSLLNIMMD---LKKCCNHPYLF--PVAAVE------APVLPNGSYDGSSL-VKSSGKLMLLQKM 1032

  Fly   508 LAAIRAEGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLF 572
            |..:|.||: :|::.|..|:.|||.|.......|.:.|:||.::...|.:.:||||.|.:..|.|
Human  1033 LKKLRDEGH-RVLIFSQMTKMLDLLEDFLEYEGYKYERIDGGITGGLRQEAIDRFNAPGAQQFCF 1096

  Fly   573 MLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQR 637
            :||::|||.|:||..|:.:.::|.||||.||.||.:|..|.||.|...|||.|...|:||:|.|.
Human  1097 LLSTRAGGLGINLATADTVIIYDSDWNPHNDIQAFSRAHRIGQNKKVMIYRFVTRASVEERITQV 1161

  Fly   638 QTHKKSLSSTII-DNNESAEKHFTRDDLKDLFTFDANILSDTHDKLKCKRCVQNIQMKPPPEDTD 701
            ...|..|:..:: ....|.....|:.:|.|:..|....|  ..|.::.........:.|.|:
Human  1162 AKRKMMLTHLVVRPGLGSKSGSMTKQELDDILKFGTEEL--FKDDVEGMMSQGQRPVTPIPD--- 1221

  Fly   702 CTSHLSQWYHCSNNRGLPDNILAQAWM--------DCKCV--SFVFHHRSQAQEIVPSAEEEATD 756
                      ..:::|  .|:.|.|..        |.|.|  |.|.|:...|...:....::|||
Human  1222 ----------VQSSKG--GNLAASAKKKHGSTPPGDNKDVEDSSVIHYDDAAISKLLDRNQDATD 1274

  Fly   757 QPE 759
            ..|
Human  1275 DTE 1277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137
		HepA	<156..650	CDD:440319	168/511 (33%)
		DEXHc_RAD54A	156..396	CDD:350825	76/254 (30%)
CHD5	NP_056372.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..134
		CHDNT	145..200	CDD:462357
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..338
		Histone-binding	343..653
		PHD1_CHD_II	345..387	CDD:277006
		PHD2_CHD_II	418..460	CDD:277007
		CD1_tandem_CHD3-4_like	465..544	CDD:349314
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	549..571
		CD2_tandem_CHD3-4_like	589..642	CDD:349309
		PLN03142	698..>1214	CDD:215601	175/554 (32%)
		DEAH box	847..850		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1209..1253		9/58 (16%)
		DUF1087	1298..1351	CDD:461922
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1351..1411
		CHDII_SANT-like	1389..1529	CDD:461920
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1524..1564
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1597..1640
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1658..1696
		CHDCT2	1733..1878	CDD:462358