Protein Alignment okr and Hltf

DIOPT Version :10

• Sequence 1: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Sequence 2: NP_033236.2
• Gene: Hltf / 20585
• MGIID: 1196437
• Length: 1003
• Species: Mus musculus
• Alignment Length: 884
• Identity: 185/884 - (20%)
• Similarity: 308/884 - (34%)
• Gaps: 336/884 - (38%)

  Fly    54 ASNTSELPLPIRFTANSEYELAIAKVLARK-FKV---------PMDN------YVPDYGGKRVLG 102
            ||||..:||.:.|....|....:.:.|.:. ||:         .::|      ..|.|.
Mouse   138 ASNTFTMPLYMTFWGKEENRNVVLEQLKKHGFKLGPTPKTLGSSLENAWGSGRAGPSYS------ 196

  Fly   103 VRRCISRRPLH-------DPMACNALVLFHPPAYTEHER-MGMDPTKVLVHVVVDPLLSNILRPH 159
                   ||.|       |.:......||..  ..|.:| :.|:|.:    .:..|||     ||
Mouse   197 -------RPAHVAVQMTTDQLKTEFDKLFED--LKEDDRTVEMEPAE----AIETPLL-----PH 243

  Fly   160 QREGVRFMYE-------------------------CVEGKRGNFNGCIMADEMGLGKTLQCVTLV 199
            |::.:.:|..                         .|:.:..|.:|.|:||:|||||||..:.::
Mouse   244 QKQALAWMIARENSKELPPFWEQRNDLYYNTITNFSVKERPENVHGGILADDMGLGKTLTAIAVI 308

  Fly   200 WT--------LLRQGPECKP--------------------------------------------T 212
            .|        |.::|.:..|                                            |
Mouse   309 LTNFDDGRPLLSKRGKKNHPGKEYKDETIKRRGSNMDKKEDGHSESSTCGEEPSISGTPEKSSCT 373

  Fly   213 INKAIVVSP-----------SSLVKNWE-KEFTKWLHGRLLCLPM------EGGT--KENTIRAL 257
            :::...|.|           ||..:..| .|..:.:.|:|..:.:      :|.:  ||::..||
Mouse   374 LSQLSSVCPKRRKISVQYIESSDSEEIETSELPQKMKGKLKNVQLNTKSRVKGSSKVKEDSKFAL 438

  Fly   258 EQFSMTSAR--------------------------LGTPVLLIS--------------YETFRIY 282
            ..|:..:.|                          :..|:.::|              :..|.:|
Mouse   439 TFFASATQRKMLKKGMSMMECSEACDTGERTRATLIICPLSVLSNWIDQFGQHVKSEVHLNFYVY 503

  Fly   283 AE---------------ILCKYEV-----G-------------MVICDEGHRLKNSDNLTYQALM 314
            ..               ||..|.:     |             .||.||||.::|.:....:|::
Mouse   504 YGPDRIRDSAWLSKQDIILTTYNILTHDYGTKDDSPLHSIKWLRVILDEGHAIRNPNAQQTKAVL 568

  Fly   315 GLKTKRRVLLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAI 379
            .|:.:||.:|:||||||.|.:.:||::|     |.......|.:...|::...|...|...:|
Mouse   569 ELEAERRWVLTGTPIQNSLKDLWSLLSF-----LKLKPFIDREWWYRIIQRPVTTGDEGGLRR-- 626

  Fly   380 EKTQELIGLVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADC--N 442
                 |..|:....:|||.....|..||         |...:.:::...:...:..|.:...  |
Mouse   627 -----LQSLIKNITLRRTKTSKIKGKPV---------LELPERKVFIQHITLSEEERKIYQSVKN 677

  Fly   443 E-KASL-------TALAD-------ITTLKKICSHPDLIYEKLTA------------REKGFENS 480
            | ||::       |.||.       :..|::||.|..|:...:::            |:...|..
Mouse   678 EGKAAIGRYFTEGTVLAHYADVLGLLLRLRQICCHTHLLTNGMSSSGPSRSDTPEELRKMLIEKM 742

  Fly   481 QNVLPS----------------------------------------------------------- 486
            :.:|.|
Mouse   743 KIILSSGSDEECAICLDSLTFPVITHCAHVFCKPCICQVIHSEQPHAKCPLCRNEIHGDNLLECP 807

  Fly   487 -------NYKPKDLNPELSGKFMLLDFMLAAIRA-EGNDKVVLISNYTQTLDLFEQLARKRKYGF 543
                   :.|...:..:.|.|...|...|..:|. :.|.|.:::|.:|..|.|.|...:...:.|
Mouse   808 PEELACDSDKESSMEWKSSSKINALMHALIELRTKDPNIKSLVVSQFTTFLSLIETPLKASGFVF 872

  Fly   544 VRLDGTMSIKKRSKVVDRFNDPESDS-FLFMLSSKAGGCGLNLIGANRLFMFDPDWNPANDEQAM 607
            .||||:|:.|||.:.:.||.:.|:.| .:.:||.||||.||||..|:|:|:.||.||||.::|..
Mouse   873 TRLDGSMAQKKRVESIQRFQNTEAGSPTIMLLSLKAGGVGLNLCAASRVFLMDPAWNPAAEDQCF 937

  Fly   608 ARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKSLSS 646
            .|..|.|||:...|.:.:...|:||.:|:.|..|:.|::
Mouse   938 DRCHRLGQKQEVIITKFIVKDSVEENMLKIQNTKRDLAA 976

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137	12/72 (17%)
		HepA	<156..650	CDD:440319	158/758 (21%)
		DEXHc_RAD54A	156..396	CDD:350825	75/409 (18%)
Hltf	NP_033236.2	DNA-binding. /evidence=ECO:0000250	38..287		32/172 (19%)
		HIRAN	60..153	CDD:400928	7/14 (50%)
		DEXHc_HLTF1_SMARC3	240..638	CDD:350829	77/414 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..373		3/55 (5%)
		HepA	<468..980	CDD:440319	121/530 (23%)
		DEGH box	551..554		2/2 (100%)
		RING-HC_HLTF	749..803	CDD:438172	0/53 (0%)
		Interaction with SP1 and SP3. /evidence=ECO:0000250	919..1003		22/58 (38%)