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Protein Alignment gammaTub23C and TUBA3E

DIOPT Version :10

Sequence 1:	NP_476804.1	Gene:	gammaTub23C / 33501	FlyBaseID:	FBgn0260639	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_997195.2	Gene:	TUBA3E / 112714	HGNCID:	20765	Length:	450	Species:	Homo sapiens

Alignment Length:	474	Identity:	143/474 - (30%)
Similarity:	248/474 - (52%)	Gaps:	35/474 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EIITLQLGQCGNQIGFEFWKRLCLEHGISPSGVL--EDFANDGLDRKDVFFYQADDDHYIPRAVL 66
            |.|::.:||.|.|||...|:..||||||.|.|.:  :.....|.|..:.||.:.....::||||.
Human     3 ECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVF 67

  Fly    67 LDLEPRVINTIMGSVYSKLYNPENVYLSKHGGGAGNNWASG-YSQGEKLQEEVFDIIDREADGSD 130
            :||||.|::.:....|.:|::||.:...|.  .|.:|:|.| |:.|:::.:.|.|.|.:.||...
Human    68 VDLEPTVVDEVRTGTYRQLFHPEQLITGKE--DAASNYARGHYTIGKEIVDLVLDRIRKLADLCT 130

  Fly   131 SLEGFILCHSIAGGTGSGMGSFIMERLADRYPKKLIQTFSVFPNQDEISDVVVQPYNSMLTLKRL 195
            .|:||::.||..||||||..|.:||||:..|.||....|:::| ..::|..||:||||:||....
Human   131 GLQGFLIFHSFGGGTGSGFASLLMERLSVDYSKKSKLEFAIYP-APQVSTAVVEPYNSILTTHTT 194

  Fly   196 TTAADSVVVLDNTALNRIACDRLHIQNPSFSQINNLVSTIMSVSTTTLRYPSYMNNNLIGLTAPL 260
            ...:|...::||.|:..|....|.|:.|:::.:|.|:..|:|..|.:||:...:|.:|......|
Human   195 LEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNL 259

  Fly   261 IPTPQLHFLMTGYTPLTSDSDIHTQQLVNVRKTTVLDVMRRLLQPKNMMVSTGPDKSNHHCYISI 325
            :|.|::||.:..|.|:.|....:.:||      :|.::.....:|.|.||...|   .|..|::.
Human   260 VPYPRIHFPLATYAPVISAEKAYHEQL------SVAEITNACFEPANQMVKCDP---RHGKYMAC 315

  Fly   326 LNIIQGEVDPTQVHKSLQRIRDRKMAQFIPWGPTSIQVALSRSSPYVQSNHRVSGL-----MLAN 385
            ..:.:|:|.|..|:.::..|:.::..||:.|.||..:|.::...|.|.....::.:     ||:|
Human   316 CMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSN 380

  Fly   386 HTSICSLFERALNQYDKLRKRGAFLDQFRREDIFKDDLNELDESRETVDCLVQEYEAATREDYMQ 450
            .|:|...:.|.::::|.:..:.||:..:..|.:   :..|..|:||.:..|.::.|..
Human   381 TTAIAEAWARLVHKFDLMYAKWAFVHWYVGEGM---EEGEFSEAREDLAALEKDCEEV------- 435

  Fly   451 FSVKRGNGPVDSKSEDSRS 469
                 |...|::::|:..:
Human   436 -----GVDSVEAEAEEGEA 449

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.