back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gammaTub23C and TUBB3

DIOPT Version :10

Sequence 1:	NP_476804.1	Gene:	gammaTub23C / 33501	FlyBaseID:	FBgn0260639	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_006077.2	Gene:	TUBB3 / 10381	HGNCID:	20772	Length:	450	Species:	Homo sapiens

Alignment Length:	451	Identity:	158/451 - (35%)
Similarity:	262/451 - (58%)	Gaps:	28/451 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EIITLQLGQCGNQIGFEFWKRLCLEHGISPSGVLEDFANDG---LDRKDVFFYQADDDHYIPRAV 65
            ||:.:|.||||||||.:||:.:..||||.|||   ::..|.   |:|..|::.:|....|:|||:
Human     3 EIVHIQAGQCGNQIGAKFWEVISDEHGIDPSG---NYVGDSDLQLERISVYYNEASSHKYVPRAI 64

  Fly    66 LLDLEPRVINTIMGSVYSKLYNPENVYLSKHGGGAGNNWASG-YSQGEKLQEEVFDIIDREADGS 129
            |:||||..::::....:..|:.|:|....:  .|||||||.| |::|.:|.:.|.|::.:|.:..
Human    65 LVDLEPGTMDSVRSGAFGHLFRPDNFIFGQ--SGAGNNWAKGHYTEGAELVDSVLDVVRKECENC 127

  Fly   130 DSLEGFILCHSIAGGTGSGMGSFIMERLADRYPKKLIQTFSVFPNQDEISDVVVQPYNSMLTLKR 194
            |.|:||.|.||:.||||||||:.::.::.:.||.:::.||||.|: .::||.||:|||:.|::.:
Human   128 DCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPS-PKVSDTVVEPYNATLSIHQ 191

  Fly   195 LTTAADSVVVLDNTALNRIACDRLHIQNPSFSQINNLVSTIMSVSTTTLRYPSYMNNNLIGLTAP 259
            |....|....:||.||..|....|.:..|::..:|:|||..||..||:||:|..:|.:|..|...
Human   192 LVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSLRFPGQLNADLRKLAVN 256

  Fly   260 LIPTPQLHFLMTGYTPLTSDSDIHTQQLVNVRKTTVLDVMRRLLQPKNMMVSTGPDKSNHHCYIS 324
            ::|.|:|||.|.|:.|||:..   :||   .|..||.::.:::...||||.:..|   .|..|::
Human   257 MVPFPRLHFFMPGFAPLTARG---SQQ---YRALTVPELTQQMFDAKNMMAACDP---RHGRYLT 312

  Fly   325 ILNIIQGEVDPTQVHKSLQRIRDRKMAQFIPWGPTSIQVALSRSSPYVQSNHRVSGLMLANHTSI 389
            :..:.:|.:...:|.:.:..|:.:..:.|:.|.|.:::||:....|   ...::|...:.|.|:|
Human   313 VATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPP---RGLKMSSTFIGNSTAI 374

  Fly   390 CSLFERALNQYDKLRKRGAFLDQFRREDIFKDDLNELDESRETVDCLV---QEYEAATRED 447
            ..||:|...|:..:.:|.|||..:..|.:   |..|..|:...::.||   |:|:.||.|:
Human   375 QELFKRISEQFTAMFRRKAFLHWYTGEGM---DEMEFTEAESNMNDLVSEYQQYQDATAEE 432

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.