Protein Alignment Syt1 and SYT13

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: NP_065877.1
• Gene: SYT13 / 57586
• HGNCID: 14962
• Length: 426
• Species: Homo sapiens
• Alignment Length: 321
• Identity: 94/321 - (29%)
• Similarity: 148/321 - (46%)
• Gaps: 38/321 - (11%)

  Fly   162 SAYKEKVQPDMEELTENA--------EEGDEEDKQSEQKLGRLNFKLEYDFNSNSLAVTVIQAEE 218
            |..|.:|..::..|.:|.        |..:.|...|..:..:|::.|:||.....|.||.::|
Human   120 SRLKRQVTEELFILPQNGVVEDVCVMETWNPEKAASWNQAPKLHYCLDYDCQKAELFVTRLEA-- 182

  Fly   219 LPALDMGGTSDPYVKVYLLPD----------KKKKFETKVHRKTLSPVFNETFTFKSLPYADAMN 273
             ...:..|..|.||:..:...          ||::..|......:.|:..|     .||.|
Human   183 -VTSNHDGGCDCYVQGSVANRTGSVEAQTALKKRQLHTTWEEGLVLPLAEE-----ELPTA---- 237

  Fly   274 KTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDL--VSVEGEGGQEKLGDICFSLRYV 336
             ||...:...||||:|...||:::.|....:.....:|.:|  .:.|...|   .|::..|:.|:
Human   238 -TLTLTLRTCDRFSRHSVAGELRLGLDGTSVPLGAAQWGELKTSAKEPSAG---AGEVLLSISYL 298

  Fly   337 PTAGKLTVVILEAKNLKKMDVGGL--SDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYNESFSFE 399
            |.|.:|.||:::||||.......|  .|..||:.:....::||||:|...|..:||.:||...||
Human   299 PAANRLLVVLIKAKNLHSNQSKELLGKDVSVKVTLKHQARKLKKKQTKRAKHKINPVWNEMIMFE 363

  Fly   400 VPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWHTL 460
            :|.:.:|...:.:.|:..|..|.|..:|.|.||...:|:|..||.:||.:|||.||.||.|
Human   364 LPDDLLQASSVELEVLGQDDSGQSCALGHCSLGLHTSGSERSHWEEMLKNPRRQIAMWHQL 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	32/135 (24%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	52/137 (38%)
SYT13	NP_065877.1	C2A_Synaptotagmin-13	160..277	CDD:176059	31/129 (24%)
		C2B_Synaptotagmin-13	288..425	CDD:176052	52/137 (38%)