Protein Alignment Syt1 and SYT2

DIOPT Version :10

• Sequence 1: NP_523460.2
• Gene: Syt1 / 33473
• FlyBaseID: FBgn0004242
• Length: 474
• Species: Drosophila melanogaster
• Sequence 2: XP_016855798.1
• Gene: SYT2 / 127833
• HGNCID: 11510
• Length: 479
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 258/470 - (54%)
• Similarity: 318/470 - (67%)
• Gaps: 50/470 - (10%)

  Fly    17 PAPASEPAADLESVDQKLEETHHSKFREVDRQEQEVLAEKAAEAASQRIAQVESTTRS-ATTEAQ 80
            |...|.||..            .:..|.:.::.||.:...|...|:..|..|:::|.| ...|:|
Human    45 PLHLSSPAVS------------SATMRNIFKRNQEPIVAPATTTATMPIGPVDNSTESGGAGESQ 97

  Fly    81 ESTTTAVPVIKKIEHVGEVVTEVIAERTGLPTWGVVAIIILVFLVVFGIIF-FCVRRFLKKRRTK 144
            |.      :..|::.  ::..|:  .:..||.|.::||.::..|::....| .|.:...||::.|
Human    98 ED------MFAKLKE--KLFNEI--NKIPLPPWALIAIAVVAGLLLLTCCFCICKKCCCKKKKNK 152

  Fly   145 --DGKGKKGV----DMKSVQLLGSAYKEKVQPDMEE-LTENAEEGDEEDKQSEQKLGRLNFKLEY 202
              .|||.|..    |||..||      .:...|.|. |||...||:||  :..:.||:|.|.|:|
Human   153 KEKGKGMKNAMNMKDMKGGQL------PQDDDDAETGLTEGEGEGEEE--KEPENLGKLQFSLDY 209

  Fly   203 DFNSNSLAVTVIQAEELPALDMGGTSDPYVKVYLLPDKKKKFETKVHRKTLSPVFNETFTFKSLP 267
            ||.:|.|.|.|:||.|||||||||||||||||:||||||||:|||||||||:|.|||||||| :|
Human   210 DFQANQLTVGVLQAAELPALDMGGTSDPYVKVFLLPDKKKKYETKVHRKTLNPAFNETFTFK-VP 273

  Fly   268 YADAMNKTLVFAIFDFDRFSKHDQIGEVKVPLCTIDLAQTIEEWRDLVSVEGEGGQ----EKLGD 328
            |.:...||||.||:|||||||||.|||||||:.|:||.|.|||||||     :||:    |||||
Human   274 YQELGGKTLVMAIYDFDRFSKHDIIGEVKVPMNTVDLGQPIEEWRDL-----QGGEKEEPEKLGD 333

  Fly   329 ICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIAIMQNGKRLKKKKTSIKKCTLNPYYN 393
            ||.|||||||||||||.||||||||||||||||||||||.:||||||||||||::||.|||||:|
Human   334 ICTSLRYVPTAGKLTVCILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTVKKKTLNPYFN 398

  Fly   394 ESFSFEVPFEQIQKICLVVTVVDYDRIGTSEPIGRCILGCMGTGTELRHWSDMLASPRRPIAQWH 458
            ||||||:|||||||:.:||||:|||::|.:|.||:..:|...|||||||||||||:|||||||||
Human   399 ESFSFEIPFEQIQKVQVVVTVLDYDKLGKNEAIGKIFVGSNATGTELRHWSDMLANPRRPIAQWH 463

  Fly   459 TLKDPEETDEIL-KN 472
            :||..||.|.:| ||
Human   464 SLKPEEEVDALLGKN 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syt1	NP_523460.2	Syt1_2_N	62..161	CDD:425364	29/106 (27%)
		C2A_Synaptotagmin-1-5-6-9-10	192..316	CDD:176031	92/123 (75%)
		C2B_Synaptotagmin-1	326..461	CDD:176047	107/134 (80%)
SYT2	XP_016855798.1	Syt2_N	61..170	CDD:409249	30/118 (25%)
		C2A_Synaptotagmin-1-5-6-9-10	199..321	CDD:176031	92/127 (72%)
		C2B_Synaptotagmin-1	331..466	CDD:176047	107/134 (80%)